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| 1 | Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing. | Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann | 2022 | Bone Research2022，10，3： | 2 |
| 2 | Biodegradation of gelatin graft copolymers Ⅵ显示文摘 | SUDESH K G KALPAGAM V NANDI U S | 1985 | J Appl Polym Sci1985，30，3： | 1 |
| 3 | Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133 + glioma stem cells to tetnozolomide therapy 显示文摘 | Ulasov I V Nandi S Dey M | 2011 | Molecular Medicine2011，17，： | 1 |
| 4 | Multi-stage heat treatment of aluminum alloy AA7049显示文摘 | RANGANATHA R NANDI V S MURALIDHARA B K | 2013 | Trans Nonferrous Met Soc China2013，23，6： | 1 |
| 5 | Follicular fluid concentrations of glucose,lactate and pyruvate in buffalo and sheep,and their effects on cultured oocytes,granulosa and cumulus cells显示文摘 | NANDI S GIRISH KUMAR V MANJUNATHA B M | 2008 | Theriogenology2008，69，2： | 1 |
| 6 | microRNA al- terations in ALDH positive mammary epithelial cells= a crucial contributing factor towardsbreast cancer risk reduction in ease of early pregnancy显示文摘 | Nandy SB Subramani R Rajamanickam V | 2014 | BMC Cancer2014，8，31： | 1 |
| 7 | Evaluation of immunocapture ELISA for diagnosis of goat pox显示文摘 | Rao T V S Nandi | 1997 | Acta Virological1997，41，： | 1 |
| 8 | Effect of trace impurities on the creep behavior of a near a titanium alloy显示文摘 | MISHRA H SATYANARAYANA D V V NANDY T K | 2008 | Scripta Materialia2008，59，6： | 1 |
| 9 | Biochemical composition of ovine follicular fluid in relation to follicle size显示文摘 | NANDI S KUMAR V G MANJUNATHA B M | 2007 | Dev Growth Differ2007，49，1： | 1 |
| 10 | Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo显示文摘 | Ulasov I V Sonabend A M Nandi S Khramtsov A Han Y Lesniak M S | 2009 | Br J Cancer2009，100，： | 1 |
| 11 | Moxifloxacin, ofloxacin, sparfloxaein, and eiprofloxacin against mycobacterium tuberculosis ; evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy显示文摘 | Shandil RK Jayaram R Kaur P Gaonkar S Suresh BL Mahesh BN Jayashree R Nandi V Bharath S Balasubramanian V | 2007 | Antimieob Agents Chemother2007，51，2： | 1 |
| 12 | Evaluation of immunocapture ELISA for diagnosis of goat pox显示文摘 | Rao T V Malik P Nandi S | 1997 | Acta Virol1997，41，6： | 1 |
| 13 | A new ordered orthorhombic phase in Ti3Al-Nb alloy显示文摘 | BANEJEE D GOGIA A K NANDI T K JOSHI V A | 1988 | Acta Metall1988，36，： | 1 |
| 14 | Blind separation of independent sources for virtually any source probability density function显示文摘 | Nandi A K | 1999 | IEEE Trans Signal Processing1999，47，9： | 1 |
| 15 | Blind separation of independent sources for virtually any source probability density function显示文摘 | Zarzoso V Nandi A K | 1999 | IEEE Transactions on Signal Processing1999，47，： | 1 |
| 16 | Effect of trace impurities on the creep behavior of a near α titanium alloy显示文摘 | MISHRA H SATYANARAYANA D V V NANDY T K SAGAR P K | 2008 | Scripta Materialia2008，59，： | 1 |
| 17 | Noninvasive fetalelectrocar-diogram extraction : blind separation versusadaptive noise cancellation显示文摘 | ZARZOSO V NANDI A | 2001 | IEEE Transactions on Biome dicalEngineering2001，48，1： | 1 |
| 18 | Noninvasive fetal electrocardiogram extraction: blind separation versus adaptive noise cancella- tion 显示文摘 | Zarzoso V Nandi A K | 2001 | IEEE Transactions on Biomedical Engineering2001，48，1： | 1 |
| 19 | A new ordered orthorhombic phase in a Ti3AI-Nb alloy 显示文摘 | BANERJEE D GOGIA A K NANDI T K JOSHI V A | 1988 | Acta Metallurgica1988，36，4： | 1 |
| 20 | Blind MIMO equalization with optimum delay using independent component analysis显示文摘 | Zarzoso V Nandi A K | 2004 | International Journal of Adaptive Control and Signal Processing2004，，18： | 1 |
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