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| 1 | Extraction and RP-HPLC determination of taxol in rat plasma, cell culture and quality control samples显示文摘A rapid,sensitive,selective and validated reverse phase high-performance liquid chromatography(RP-HPLC)method for the estimation of paclitaxel in micro-sample of rat plasma and in culture of cancer cells was performed in this study.The mobile phase consisted of an optimized mixture of methanol:water:trifluroacetic acid(80:20:0.1,v/v/v).Column elution at a flow rate of 1 mL/minute with UV detection at 225 nm at room temperature was used.The RP-HPLC method was successfully applied for the determination of paclitaxel in plasma samples and in culture of cancer cells with nano-quantity of estimation.The validation studies were performed in accordance with the International Conference on Harmonization(ICH)guidelines.The intra-and inter-day precision showed that the coefficients of variation ranged from 1.07%to 4.27%at different levels of concentrations.To the best of our knowledge,this study also reported for the first time the optimization of different solvents for effective extraction of paclitaxel wherein tert.-butyl methyl ether(TBME):diethyl ether(DEE)in 50:50 v/v composition was found most efficient with extraction efficiency ranging between 77.99%and 91.74%and between 76.14 and 93.66%in the plasma and cell culture,respectively.This proposed method was successfully applied to study the pharmacokinetics of paclitaxel and the influence of verapamil and all-trans retinoic acid(atRA)on paclitaxel pharmacokinetics in rat models.This proposed method might emerge as a valuable aid in the laboratory monitoring of paclitaxel in a variety of in vitro as well as in vivo scenarios. | Rakesh Kumar Tekade Antony D'Emanuele Abdelbary Elhissi Ashish Agrawal Anurekha Jain Basel Tawfiq Arafat Narendra Kumar Jain | 2013 | The Journal of Biomedical Research2013，27，5： | 5 |
| 2 | Simulation study of the superharmonic field generated from a phase array transducer显示文摘Ultrasound imaging is the most widely used noninvasive medical imaging modality. Its latest elite concept is Superharmonic Imaging which is the most talked-about future of medical diagnostic ultrasound.In this paper,the computational and analytical study for superharmonic field generation from phased array transducer of 16×16 elements is presented. For this,the model preferred,includes the calculation for diffraction effect in frequency domain and nonlinear effect in time domain.The attenuation is included along with the diffraction in frequency domain as well.The comparative analysis of superharmonic field is also carried out with simulated fundamental and second harmonic fields by the same model.Similarly,the comparison with the results from the literature is also reported. | Narendra D Londhe R.S.Anand | 2011 | Chinese Journal of Acoustics2011，30，4： | 2 |
| 3 | Mechanisms of mitophagy显示文摘 | Youle R J Narendra D P | 2011 | Nat Rev Mol Cell Biol2011，12，1： | 1 |
| 4 | p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both显示文摘 | Narendra D Kane LA Hauser DN | 2010 | Autophagy2010，6，8： | 1 |
| 5 | Reduced hepatic toxicity, enhanced cellular uptake and altered pharmacokinetics of stavudine loaded galactosylated liposomes 显示文摘 | MINAKSHI G TATHAGATA D NARENDRA KUMAR JA | 2007 | Eur J Pharm Biopharm2007，67，1： | 1 |
| 6 | Thermal and catalytic upgrading of a biomass-derived oil in a dual reaction system显示文摘 | SRIMAT T S AJAY K D NARENDRA N B | 2000 | The Canadian Journal of Chemical Engineering2000，78，： | 1 |
| 7 | Fair Queueing With Service Envelopes(FQSE):A Cousin-Fair Hierarchieal Scheduler for Subscriber Access Networks显示文摘 | KRAMER G NARENDRA K SUDHIR D | 2004 | IEEE Journal on Selected Areas in Communications2004，22，8： | 1 |
| 8 | Tensile deformation and fracture behavior of an oxide dispersion strengthened copper alloy显示文摘 | Srivatsan T S Narendra N Troxell J D | 2000 | Materials and Design2000，21，3： | 1 |
| 9 | Parkin is recruited selectively to impaired mitoehondria and promotes their autophagy显示文摘 | Narendra D Tanaka A Suen DF | 2008 | J Cell Biol2008，183，5： | 1 |
| 10 | Laser surface engineered TiC coating on 6061 A1 alloy: microstructure and wear显示文摘 | LALITHA R K ARVIND A NARENDRA B D | 2000 | Applied Surface Science2000，153，： | 1 |
| 11 | Tensile deformation and fracture behavior of an oxide dispersion strengthened copper alloy显示文摘 | Srivatsan T S Narendra N Troxell J D | | 0，，： | 1 |
| 12 | Detecting faces in images:A survey显示文摘 | YANG Minghsuan KRIEGMAN D J NARENDRA A | 2002 | IEEE Trans Pattern Analysis and Machine Intelligence2002，24，1： | 1 |
| 13 | Synthesis of TiB2- TiC/Fe nano-eomposite coating by laser surface engineering 显示文摘 | Du B H Sameer R P Narendra B D | 2013 | Optics & Laser Technology2013，45，： | 1 |
| 14 | Parkin is recruited selectively to impaired mitochondria and promotes their autophagy显示文摘 | Narendra D Tanaka A Suen DF | 2008 | J Cell Biol2008，183，5： | 1 |
| 15 | Predicting the effects of land use change on water and salt balance- A case study of a catchment affected by dry land salinity in NSW, Australia显示文摘 | NARENDRA K T EOFFREY B ARRICK D | 2003 | Journal of Hydrology2003，283，14： | 1 |
| 16 | The controllability of planar bilinear systems显示文摘 | KODITSCHEK D E NARENDRA K S | 1985 | IEEE Transactions on Automatic Control1985，30，1： | 1 |
| 17 | Nanocoatings for engine application 显示文摘 | Narendra B D Nayak S | 2005 | Surface & Coatings Technology2005，194，1： | 1 |
| 18 | Detecring faces in images:A survey显示文摘 | Yang Ming-Hsuan Kriegman D Narendra A | 2002 | IEEE Trans on Pattern Analysis and Machine Intelligence2002，4，1： | 1 |
| 19 | Soil carbon sequestration as affected by slope aspect under restoration treatments of a degraded alfisol in the Indian sub-tropics显示文摘 | Narendra K L Sudhishri S Anchal D | 2013 | Geoderma2013，，： | 1 |
| 20 | What constitutes adequate surgical therapy for benign nodular goiter 显示文摘 | Phitayakom R Narendra D Bell S | 2009 | J Surg Res2009，154，1： | 1 |
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