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| 1 | Clinical and cost impact of intravenous proton pump inhibitor use in non-ICU patients显示文摘AIM:To assess the appropriateness of the indication and route of administration of proton-pump-inhibitors (PPIs) and their associated cost impact. METHODS:Data collection was performed prospec-tively during a 6-mo period on 340 patients who re-ceived omeprazole intravenously during their hospital stay in non-intensive care floors. Updated guidelines were used to assess the appropriateness of the indication and route of administration. RESULTS:Complete data collection was available for 286 patients which were used to assess intravenous (IV) PPIs utilization. Around 88% of patients were receiving PPIs for claimed stress ulcer prophylaxis (SUP) indication; of which,only 17% met the guideline criteria for SUP indication,14% met the criteria for non-steroidal-anti-inflammatory drugs-induced ulcer prophylaxis,while the remaining 69% were identifi ed as having an unjustified indication for PPI use. Theinitiation of IV PPIs was appropriate in 55% of pa-tients. Half of these patients were candidates for switching to the oral dosage form during their hos-pitalization,while only 36.7% of these patients were actually switched. The inappropriate initiation of PPIs via the IV route was more likely to take place on the medical floor than the surgical floor (53% vs 36%,P = 0.003). The cost analysis associated with the appro-priateness of the indication for PPI use as well as the route of administration of PPI revealed a possible saving of up to $17 732.5 and $14 571,respectively. CONCLUSION:This study highlights the over-utili-zation of IV PPIs in non-intensive care unit patients. Restriction of IV PPI use for justified indications and route of administration is recommended. | Soumana C Nasser Jeanette G Nassif Hani I Dimassi | 2010 | World Journal of Gastroenterology2010，16，8： | 23 |
| 2 | Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes显示文摘AIM: To investigate the influence of proton pump inhibitors(PPIs) exposure on the diagnosis of Helicobacter pylori(H. pylori) gastritis and intestinal metaplasia.METHODS: Chronic PPI use is associated with masking of H. pylori infection. Patients with H. pylori infection are predisposed to gastric and duodenal ulcers, and long-term infection with this organism has been associated with gastric mucosal atrophy and serious long-term complications, such as gastric lymphoma and adenocarcinoma. Three hundred patients diagnosed with gastritis between January 2008 and April 2010 were included in our study. The computerized medical database of these patients was reviewed retrospectively in order to assess whether the type of gastritis diagnosed(H. pylori vs non-H. pylori gastritis) is influenced by PPI exposure. H. pylori density was graded as low, if corresponding to mild density following the Updated Sydney System, or high, if corresponding to moderate or severe densities in the Updated Sydney System.RESULTS: Patients were equally distributed between males and females with a median age at the time of diagnosis of 50 years old(range: 20-87). The histological types of gastritis were classified as H. pylori gastritis(n = 156, 52%) and non-H. pylori gastritis(n = 144, 48%). All patients with non-H. pylori gastritis had inactive chronic gastritis. Patients with no previous PPI exposure were more likely to be diagnosed with H. pylori gastritis than those with previous PPI exposure(71% vs 34.2%, P < 0.001). Intestinal metaplasiawas more likely to be detected in the latter patients(1.4% vs 6.5%, P = 0.023). Multivariate analysis has also demonstrated that in the presence of previous PPI exposure(OR = 0.217, 95%CI: 0.123-0.385), GERD(OR = 0.317, 95%CI: 0.132-0.763, P = 0.01), alcohol intake(OR = 0.396, 95%CI: 0.195-0.804, P = 0.01), the detection of H. pylori was less likely. Chronic use of PPIs may mask H. pylori infections promoting the diagnosis of non-H. pylori gastritis and leads to a significant drop in H. pylori densities and to an increased risk of intestinal metaplasia.CONCLUSION: The use of PPIs masks H. pylori infection, promotes the diagnosis of non-H. pylori inactive chronic gastritis diagnosis, and increases the incidence of intestinal metaplasia. | Soumana C Nasser Mahmoud Slim Jeanette G Nassif Selim M Nasser | 2015 | World Journal of Gastroenterology2015，21，15： | 7 |
| 3 | 使用OCT评估中心性浆液性脉络膜视网膜病变患者脉络膜厚度的变化显示文摘目的:使用光谱域光学相干断层成像(SD-OCT)技术研究中心性浆液性脉络膜视网膜病变(CSCR)3mo后脉络膜厚度的变化。方法:前瞻性研究。共纳入60眼,20眼(平均年龄:33.65±5.24岁)典型急性单侧中心性浆液性脉络膜视网膜病变以及对侧正常眼,20眼为健康对照组。进行荧光素血管造影和OCT检查。测量中心凹下脉络膜厚度(SFCT),黄斑中心凹视网膜厚度(CMT),到中央凹和视网膜下液1000μm处颞部和鼻部。结果:在三个不同的位置,三组间的SFCT差异有统计学意义。中心性浆液性脉络膜视网膜病变眼中心凹下脉络膜厚度(372.40±34.39μm)在基线和随访3mo后均显著大于对侧正常眼(302.10±8.9μm)和对照组眼(279.80±14.49μm)。CSCR眼平均CMT为317±141.86μm,并且SFCT与CMT呈显著正相关。结论:不同部位脉络膜厚度的增加,以及被称为“厚脉络膜”的过度扩张和高渗透血管,似乎在包括中心性浆液性脉络膜视网膜病变在内的广泛疾病中起着重要作用。 | Ragai Magdy Hatata Mohamed Abdelhamid Nassif Sherin Hassan Sadek | 2020 | 国际眼科杂志2020，20，4： | 5 |
| 4 | Video capsule endoscopy in left ventricular assist device recipients with obscure gastrointestinal bleeding显示文摘AIM: To assess whether video capsule endoscopy(VCE) affects the outcomes of left ventricular assist devices(LVADs) recipients with gastrointestinal bleeding.METHODS: This is a retrospective study of LVAD recipients with obscure gastrointestinal bleeding(OGIB) who underwent VCE at a tertiary medical center between 2005 and 2013. All patients were admitted and monitored with telemetry and all VCE and subsequent endoscopic procedures were performed as inpatients. A VCE study was considered positive only when P2 lesions were found and was regarded as negative if P1 or P0 were identified. All patients were followed until heart transplant, death, or the end of the study.RESULTS: Between 2005 and 2013, 30 patients with LVAD underwent VCE. Completion rate of VCE was 93.3% and there was no capsule retention. No interference of VCE recording or the function of LVAD was found. VCE was positive in 40% of patients(n = 12). The most common finding was active small intestinal bleeding(50%) and small intestinal angiodysplasia(33.3%). There was no difference in the rate of recurrent bleeding between patients with positive and negative VCE study(50.0% vs 55.6%,P = 1.00) during an average of 11.6 ± 9.6 mo follow up. Among patients with positive VCE, the recurrent bleeding rate did not differ whether subsequent endoscopy was performed(50% vs 50%, P = 1.00).CONCLUSION: VCE can be safely performed in LVAD recipients with a diagnostic yield of 40%. VCE does not affect recurrent bleeding in LVAD patients regardless of findings. | Surachai Amornsawadwattana Michael Nassif David Raymer Shane La Rue Chien-Huan Chen | 2016 | World Journal of Gastroenterology2016，22，18： | 2 |
| 5 | In vivo human retinal imaging by ultrahigh- speed spectral domain optical coherence tomography显示文摘 | Nassif N Cense B | 2004 | Opt Lett2004，29，5： | 1 |
| 6 | Retention and thermodynamic characteristics of mercury(II) complexes onto polyurethane foams显示文摘 | EL-SHAHAWI M S NASSIF H A | 2003 | Analytica Chimica Acta2003，481，1： | 1 |
| 7 | Extemally prestressed members: Evaluation of second-order effects 显示文摘 | Harajli M Khairallah N Nassif H | 1999 | Journal of Structural Engineering1999，125，10： | 1 |
| 8 | Externaly prestressed members: evallustion of second order elects显示文摘 | Harajli M Khairallah N Nassif H | 1999 | Journal of Structural Engineering1999，，3： | 1 |
| 9 | Ventilation control strategy using the supply CO2 concentration setpoint 显示文摘 | NASSIF N KAJL S SABOURIN R S | 2005 | HVAC&R Research2005，11，2： | 1 |
| 10 | Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons显示文摘 | Castillo K Nassif M Valenzuela V | 2013 | Autophagy2013，9，9： | 1 |
| 11 | Prevalence and prognostic Significance of preprocedural cardiac troponin elevation among patients with stable coronary intervention显示文摘 | Allen J Kleiman NS Nassif D | | 0，，06： | 1 |
| 12 | Early neurogene- sis of the Drosophila brain 显示文摘 | Younossi-Hartenstein A Nassif C Green P | 1996 | J Comp Neurol1996，370，3： | 1 |
| 13 | Amorphous layer around aragonite platelets in nacre显示文摘 | Nassif N | 2005 | PNAS2005，102，12： | 1 |
| 14 | Clinicopathologic features of post‐transplant lymphoproliferative disorders arising after pediatric small bowel transplant显示文摘 | S. Nassif S. Kaufman S. Vahdat N. Yazigi B. Kallakury E. Island M. Ozdemirli | 2013 | Pediatr Transplantation2013，，8： | 1 |
| 15 | Analysis of the genetic differences between Neisseria meningitidis and Neisseria gonorrhoeae:Two closely related bacteria expressing two different pathogenicities显示文摘 | Tinsley C R Nassif X | 1996 | Proc Natl Acad Sci USA1996，93，11： | 1 |
| 16 | Toxic epidermal necrolysis: effector cells are drug-specific cytotoxic T cells 显示文摘 | NASSIF A BENSUSSAN A BOUMSELL L | 2004 | Allergy Clin Immunol2004，114，5： | 1 |
| 17 | Retention and thermodynamic characteristics of mercury (Ⅱ) complexes onto polyurethane foams 显示文摘 | El-Shahawi M S Nassif H A | 2003 | Analytica Chimica Acta2003，481，1： | 1 |
| 18 | The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells:alteration in tumor suppressor and cell cycle-regulatory proteins 显示文摘 | Goldberg Y Nassif II Pittas A | 1996 | Oncogene1996，12，4： | 1 |
| 19 | Exter- nally Prestressed Members: Evaluation of Second- order Effects显示文摘 | HARAJLI M KHAIRALLAH N NASSIF H | 1999 | Journal of Structural Engineering1999，125，10： | 1 |
| 20 | Evaluation of the potential role of cytokines in toxic epidermal necrolysis显示文摘 | Nassif A Moslehi H Le Gouvello S | 2004 | J Invest Dermatol2004，123，5： | 1 |
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