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| 1 | Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes显示文摘AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer disease(PUD).METHODS:Administrative databases identified all hospitalizations for UGIB secondary to PUD in Alberta,Canada from 2004 to 2010(n=7079)using the International Classification of Diseases Codes(ICD-10).A subset of the data was validated using endoscopy reports.Positive predictive value and sensitivity with 95%confidence intervals(CI)were calculated.Incidence of UGIB secondary to PUD was calculated.Logistic regression was used to evaluate surgery,in-hospital mortality,and 30-d readmission to hospital with recurrent UGIB secondary to PUD.Co-variants accounted for in our logistic regression model included:age,sex,area of residence(i.e.,urban vs rural),number of Charlson comorbidities,presence of perforated PUD,undergoing upper endoscopy,year of admission,and interventional radiological attempt at controlling bleeding.A subgroup analysis(n=6356)compared outcomes of patients with gastric ulcers to those with duodenal ulcers.Adjusted estimates are presented as odds ratios(OR)with95%CI.RESULTS:The positive predictive value and sensitivity of ICD-10 coding for UGIB secondary to PUD were85.2%(95%CI:80.2%-90.2%)and 77.1%(95%CI:69.1%-85.2%),respectively.The annual incidence between 2004 and 2010 ranged from 35.4 to 41.2 per100000.Overall risk of surgery,in-hospital mortality,and 30-d readmission to hospital for UGIB secondary to PUD were 4.3%,8.5%,and 4.7%,respectively.Interventional radiology to control bleeding was performed in 0.6%of patients and 76%of these patients avoided surgical intervention.Thirty-day readmission significantly increased from 3.1%in 2004 to 5.2%in 2010(OR=1.07;95%CI:1.01-1.14).Rural residents(OR rural vs urban:2.35;95%CI:1.83-3.01)and older individuals(OR≥65 vs<65:1.57;95%CI:1.21-2.04)were at higher odds of being readmitted to hospital.Patients with duodenal ulcers had higher odds of dying(OR=1.27;95%CI:1.05-1.53),requiring surgery(OR=1.73;95%CI:1.34-2.23),and being readmitted to hospital(OR=1.54;95%CI:1.19-1.99)when compared to gastric ulcers.CONCLUSION:UGIB secondary to PUD,particularly duodenal ulcers,was associated with significant morbidity and mortality.Early readmissions increased over time and occurred more commonly in rural areas. | Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan | 2014 | World Journal of Gastroenterology2014，20，46： | 21 |
| 2 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 3 | Slacklining and stroke: A rehabilitation case study considering balance and lower limb weakness显示文摘To ascertain the effectiveness of slacklining as a supplementary therapy for elderly stroke patients who are functionally non-progressing. This case study involved an 18-mo prospective observation of the management of an 87-year-old female stroke-patient of the left hemisphere with reduced balance, reduced lower limb muscular activation, hypertonia, and concurrent postural deficits. This entailed the initial acute care phase through to discharge to home and 18-mo final status in her original independent living setting. The introduction of slacklining as an adjunct therapy was made 12 mo post incident. Slacklining involves balance retention on a tightened band where external environmental changes cause a whole-body dynamic response to retain equilibrium. It is a complex neuromechanical task enabling individualized self-developed response strategies to be learned and adapted. This facilitates the innate process of balance retention, lower-limb and core muscle activation, and stable posture through a combination of learned motor skills and neurological system down regulation. Individuals adopt and follow established sequential motor learning stages where the acquired balance skillsare achieved in a challenging composite-chain activity. Slacklining could be considered an adjunct therapy for lower limb stroke rehabilitation where function is compromised due to decreased muscle recruitment, decreased postural control and compromised balance. Initial inpatient rehabilitation involved one-month acute-care, one-month rehabilitation, and one-month transitional care prior to home discharge. A further six months of intensive outpatient rehabilitation was provided with five hourly sessions per week including:supervised and self-managed hydrotherapy, plus one individual and two group falls' prevention sessions. These were supported by daily home exercises. At 12 mo post incident, recovery plateaued, then regressed following three falls. Rehabilitation was subsequently modified with the hydrotherapy retained and the group sessions replaced with an additional individual session supplemented with slacklining. The slacklining followed stages one and two of a standardized five-stage protocol. Self-reported functional progression resumed with improvement by 14 mo which further increased and was sustained 18 mo(Students' t test P < 0.05). Slacklining's external stimulations activate global-body responses through innate balance, optimal postural and potentially down-regulated reflex control. Incorporated into stroke rehabilitation programs, slacklining can provide measurable functional gains. | Charles P Gabel Natalie Rando Markus Melloh | 2016 | World Journal of Orthopedics2016，7，8： | 2 |
| 4 | Development of Organizational Commitment During the First Year of Employment: A Longitudinal Study of Pre - and Post - Entry Influ- ences 显示文摘 | JOHN P MEYER D RAMONA BOBOCEL NATALIE J ALLEN | 1991 | Journal of Management1991，17，： | 1 |
| 5 | Control of the critical dimension with a trilayer nanoimprint lithography procedure显示文摘 | Lebib A Natali M Li S P | 2001 | Microelectronic Engineering2001，5758，： | 1 |
| 6 | Prognostic factors in surgically resected N2 NSCLC : the importance of patterns of mediastinal lymph nodes metastases 显示文摘 | Casali C Stefani A Natali P | 2005 | Eur J Cardiothorac Surg2005，28，1： | 1 |
| 7 | Thermo-dynamic properties of cubane显示文摘 | Kybett B D Carroll S Natalis P | 1966 | J Arh Chem Soc1966，88，3： | 1 |
| 8 | Expression of class I and class II major histocompatibility complex antigens on human hepatocytes显示文摘 | Franco A Barnaba V Natali P et ol | 1988 | Hepatology1988，8，3： | 1 |
| 9 | Prognostic factors in surgically re- sectcd N2 non-snmlt cell lung cancer: the importance of patterns of mediastinal lymph nodes metastases 显示文摘 | Casali C Stefani A Natali P | 2008 | Eur Cardiothorac Surg2008，28，1： | 1 |
| 10 | Supplementation with Vitamins C and E Inhibits the Release of Interleukin -6 from Contracting Human Skeletal Muscle显示文摘 | CHRISTIAN P FISCHER NATALIE J HISCOCK | 2004 | J Physiol2004，558，2： | 1 |
| 11 | A Three-compoentConceptualization of Organizational Commitment 显示文摘 | Meyer John P Allen Natalie J | 1991 | Human Resource Management Review1991，91，1： | 1 |
| 12 | Long-term outcome after Hirschsprung's disease:patients' perspectives显示文摘 | Natalie LY Soucy P | | 0，，07： | 1 |
| 13 | Coronary atherosclerosis in type II diabetes:angiographic findings and clinical outcome显示文摘 | Natali A Vichi S Landi P | 2000 | Diabetolo- gia2000，43，5： | 1 |
| 14 | Numerical analysis of tooth mobility: Formulation of a non-linear constitutive law for the periodontal ligament 显示文摘 | Natali A N Pavan P G Scarpa C | 2004 | Dental Materials2004，20，7： | 1 |
| 15 | Community pharmacists' opinions about having diagnostic data provided with prescriptions显示文摘 | EDWARD P ARMSTRONG NATALIE M G | 2003 | J Pharm Pract2003，16，5： | 1 |
| 16 | Experimental- numerical analysis of minipig's multi-rooted teeth 显示文摘 | Natali A N Camiel E L Pavan P G | 2007 | Journal of Biomechanies2007，40，8： | 1 |
| 17 | Coronary atherc,sclerosis in type Ⅱ diabetes: Angiographical findings and clinical outcome显示文摘 | Natali A Vichi S Landi P | 2000 | Diabetologia2000，43，： | 1 |
| 18 | Epidemiological chronorisk of stroke显示文摘 | Pasqualetti P Natali G Casale R | 1990 | Aeta N eurol Stand1990，81，1： | 1 |
| 19 | Distribution and molecular characterization of a cell-surface and a cytoplasmic antigen detectable in human melanoma cells with monoclonal antibodies显示文摘 | Wilson B S Imai K Natali P G | 1981 | Int J Cancer1981，28，3： | 1 |
| 20 | Supplementation with vitamins c and e inhibits the release of interleukin-6 from contracting human skeletal muscle显示文摘 | CHRISTIAN P FISCHER NATALIE J HISCOCK MILENA PENKOWA | 2004 | J Physiol2004，558，2： | 1 |
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