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| 1 | 孕产期抑郁症生物标志物的研究进展显示文摘孕产期抑郁症是围产期常见的并发症之一,严重影响母儿身心健康。目前,早期诊断孕产期抑郁症尤为困难,客观有效的生物学标志物对早发现早治疗孕产期抑郁症意义重大。近年来探索孕产期抑郁症早期诊断的生物标志物成为研究热点,主要在性激素、神经内分泌相关激素、免疫炎症分子、遗传及表观遗传学等方面。本文就近年来孕产期抑郁症生物学标志物的研究进展进行综述。 | 章柳宵 Obore Nathan 虞天一 钱惠勤 张媛 于红 | 2022 | 中国药科大学学报2022，53，1： | 1 |
| 2 | The 100 top-cited articles on childhood obesity: a bibliometric analysis显示文摘Background:Childhood obesity(CHO)is a serious global health challenge affecting both developed and developing nations.The feats attained in addressing this global health challenge can be reflected through the top-cited studies.The study’s aim was to analyze the features of the 100 top-cited articles concerning CHO.Methods:We used a bibliometric analysis,and searched for relevant articles from the Web of Science(December 1,2021),using an appropriate keyword search-strategy((child OR childhood OR children OR adolescent)AND(obese OR obesity OR overweight)).The retrieved documents were analysed based on the citation number,publication year,authorship,institution,journal and country.The analyses were performed mainly by the Bibliometrix application(using R-studio cloud)and HistCite.Results:The 100 top-cited articles were published between 1976 and 2018,their citations ranged from 365 to 10789,with a mean citation of 1146.2 and 31 studies had more than 1000 citations.The articles were published in 31 journals,with the“Pediatrics”journal having the most publications(n=18).The studies were from 12 countries,with the most-productive being the USA(n=68),followed by the United Kingdom(n=12)and France(n=3).The leading institution was the University of Bristol(n=8),while Dietz WH(n=12),and Flegal KM(n=8)were the most productive authors.The most common research fields covered by these articles were;“General Internal Medicine”(n=34),“Pediatrics”(n=29),and“Nutrition Dietetics”(n=18).The study noted significant correlations between the total article citation and the number of authors(R=0.203),countries involved(R=0.407),institutions(R=0.407),and the publication year(R=0.847),all with P<0.001.Conclusions:Through these top-cited articles,this analysis provides discernment into the historical advancements,including the prime roles performed by various stakeholders in addressing the issue of CHO.However,Asian countries’contribution is not adequately reflected in these articles,and thus more focus and funding for CHO research are needed for effectual prevention and control. | Joseph Kawuki Taha Hussein Musa Upama Ghimire Nathan Obore Shireen Salome Papabathini | 2022 | Global Health Journal2022，6，3： | 1 |
| 3 | 中国人群产后抑郁状态与纯母乳喂养关联的Meta分析显示文摘目的探究中国人群产后抑郁状态与纯母乳喂养的关联强度。方法检索万方、SinoMed、知网等数据库,查找中国人群产后抑郁状态与纯母乳喂养情况的观察性研究。采用Stata 12.0软件进行Meta分析。并根据地区、产后时间、分组依据及纳入人群进行亚组分析。结果共纳入16篇观察性研究。总体分析抑郁状态组较对照组纯母乳喂养比例低,差异有统计学意义(OR=0.44,95%CI:0.36~0.54,P<0.001)。亚组分析提示处于产后抑郁状态的女性纯母乳喂养比例在东部地区显著降低(OR=0.45,95%CI:0.36~0.56,P<0.001),在中西部地区也降低(OR=0.41,95%CI:0.25~0.66,P<0.001);产后42 d内处于产后抑郁状态的产妇中纯母乳喂养比例降低(OR=0.48,95%CI:0.37~0.61,P<0.001),在产后42 d~6月降低更为显著(OR=0.35,95%CI:0.21~0.60,P<0.001);去除不同分组依据及纳入人群的研究,剩余研究结果与总体结果差异不大,差异均有统计学意义(OR=0.45,95%CI:0.36~0.56,P<0.001)。Meta回归分析提示研究间的异质性地区(P=0.906)、产后时间(P=0.528)、分组依据及纳入人群(P=0.722)差异无统计学意义。结论与对照组相比较,产后抑郁状态人群中纯母乳喂养的比例低。为提高中国人群6个月内纯母乳喂养率、降低产后抑郁患病率,建议从产前开始进行孕产期抑郁筛查及多学科协作干预。 | 李璇 Obore Nathan 陶昱辰 胡燕 王一枭 洪翔 王蓓 于红 | 2023 | 中华疾病控制杂志2023，27，11： | 0 |
| 4 | Pregnant Women with Severe Factor VII Deficiency Undergoing Cesarean Section Managed with a Short-Term Regimen of Recombinant Factor VIIa显示文摘To editor:Factor VII(FVII)is a determining factor in activating the exogenous coagulation pathway;F7 gene mutation decreases the FVII number or function.Factor VII deficiency(FVIID)is characterized by an isolated prolongation of the prothrombin time(PT)with a normal activated partial thromboplastin time(aPTT).Factor assay and genotyping for FVII can be done to confirm the diagnosis.1,2 Patients may present with menorrhagia,and bleeding tendencies may vary from slight gingival bleeding,epistaxis,and ecchymosis,to severe bleeding,such as gastrointestinal and intracranial bleeding. | Nathan Obore Wan Jin Qian Huiqin Qian Wei Hu Yan Yu Hong | 2023 | Maternal-Fetal Medicine2023，5，3： | 0 |
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