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| 1 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 2 | Chloroplast DNA diversity in populations of wild and cultivated barley显示文摘 | Neele D B Saghai M A Allard R W | 1988 | Genetics1988，120，： | 1 |
| 3 | Early glottic carcinoma treated with open laryngeal procedures 显示文摘 | Thomas J V Olsen K D Neel H B | 1994 | Arch Otolaryngol Head Neck Surg1994，120，： | 1 |
| 4 | The tyrosine phosphatase Shp2 (PTPN 11) in eancer显示文摘 | Chan G Kalaitzidis D Neel B G | 2008 | Cancer Metaslasis Rev2008，27，2： | 1 |
| 5 | Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation显示文摘 | Matin T.M Keith K Davies B Conner D.A Guha P Kalaitzidis D Wu X Lauriol J Wang B Bauer M Bronson R Franchini K.G Neel B.G Kontaridis M.I | | 0，，： | 1 |
| 6 | The tyrosine phosphatase Shp2 (PTPN11) in cancer 显示文摘 | Chan G Kalaitzidis D Neel B G | 2008 | Cancer and metastasis reviews2008，27，2： | 1 |
| 7 | Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation 显示文摘 | Bruecher-Encke B Griffin J D Neel B G | 2001 | Leukemia2001，15，9： | 1 |
| 8 | Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2显示文摘 | Barford D Neel B G | 1998 | Structure1998，6，3： | 1 |
| 9 | Allergic fungal sinusitis:the mayo clinic experiences显示文摘 | Cody D T Neel H B Ferreiro J A | 2004 | Laryngoscope2004，104，2： | 1 |
| 10 | Roleof the tyrosine phosphatase SHP - 1 in K562 cell differentia- tion显示文摘 | Bruecher E B Griffin J D Neel B G | 2001 | Leukemia2001，15，9： | 1 |
| 11 | Early glottic carci- noma treated with open laryngeal procedures 显示文摘 | Thomas J V Olsen K D Neel H B | 1994 | Arch Otolaryngol Head Neck Surg1994，120，5： | 1 |
| 12 | Identification of an early-growth response gene encoding a novel putative protein kinase 显示文摘 | Simmons D L Neel B G Stevens R | 1992 | Mol Cell Biol1992，12，9： | 1 |
| 13 | The tyrosine phosphatase Shp2 (PTPNll) in cancer显示文摘 | Chan G Kalaitzidis D Neel B G | 2008 | Cancer Metastasis Rev2008，，17： | 1 |
| 14 | Price sur- charge and the effects of construal level显示文摘 | Albinsson P A Bidisha B Neel D | 2010 | Journal of Ap- plied Business and Economics2010，11，4： | 1 |
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