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| 1 | 有无椎间支撑的侧方腰椎椎体间融合术应用单双侧椎弓根螺钉固定的生物力学稳定性比较显示文摘侧方腰椎椎体间融合术(Lateral lumbar interbody fusion,LLIF)是侧方入路的微创腰椎间融合手术,在不损伤腰背部肌肉、韧带和小关节的同时,可置入体积更大的椎体间融合器。由于椎间盘切除后仅置入椎体间融合器难以提供足够的稳定性,因此LLIF术中多采用单侧椎弓根螺钉(unilateral pediclescrews,UPS)或双侧椎弓根螺钉(bilateral pedicle screws,BPS)来加强稳定性。本研究旨在探讨UPS或BPS固定是否能为LLIF提供更好的生物力学稳定,同时比较两种固定方式的稳定性差异。 | Godzik J Martinez-Del-Campo E Newcomb AGUS 梁达轩 吴增晖 | 2018 | 中国骨科临床与基础研究杂志2018，10，5： | 10 |
| 2 | Non-steroidal anti-inflammatory drugs and statins in relation to colorectal cancer risk显示文摘AIM:To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs(NSAIDs) or statins and colorectal cancer risk.METHODS:In a population-based case-control study in women,we examined the association between NSAIDs and statin use and the risk of colorectal cancers.We further investigated whether the use of statins modifies the protective effect of NSAIDs.Female cases(n = 669) of colorectal cancer aged 50-74 years were identified from a statewide registry in Wisconsin during 1999-2001.Community control women(n = 1375) were randomly selected from lists of licensed drivers and Medicare beneficiaries.Medication use and risk factor information were gathered during a structured telephone interview.A multivariable logistic regression model was used to calculate odds ratio(OR) and 95% conf idence interval(CI) .RESULTS:Overall,NSAIDs users had a 30% reduction in risk of colorectal cancer(95% CI:0.56-0.88) .Statin use was not associated with colorectal cancer risk(OR = 1.17,95% CI:0.74-1.85) ,regardless of structural type(lipophilic or hydrophilic) ,duration of use,or recency.There was no evidence of an interaction between NSAIDs and statins and colorectal cancer risk(P-interaction = 0.28) .CONCLUSION:Although our results confirm the inverse association between NSAIDs use and colorectal cancer risk,they do not support a risk reduction in statin users,or an interaction effect of combined NSAIDs and statin use. | Mazyar Shadman Polly A Newcomb John M Hampton Karen J Wernli Amy Trentham-Dietz | 2009 | World Journal of Gastroenterology2009，15，19： | 5 |
| 3 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 4 | Automatic Linkage of Vital Records 显示文摘 | NEWCOMBE H KENNEDY J AXFORD S | 1959 | Science1959，130，： | 1 |
| 5 | Four coun- try healthcare-associated infection prevalence survey: pneu- monia and lower respiratory tract infections 显示文摘 | Humphreys H Newcombe RG Enstone J | 2010 | J Hosp Infect2010，74，3： | 1 |
| 6 | Four country healthcare-associated infection prevalence sur- vey: pneumonia and lower respiratory tract infections显示文摘 | HUMPHREYS H NEWCOMBE R G ENSTONE J | 2010 | Journal of Hospital Infection2010，74，3： | 1 |
| 7 | Expansion and contraction of the Sahara desert from 1980 to 1990显示文摘 | Dregne H E Newcomb W W | 1991 | Science1991，253，： | 1 |
| 8 | The lysine requirement of lactating primiparous sow显示文摘 | TOUCHETTE K J ALLEE G L NEWCOMB M D | 1998 | Journal of Animal Science1998，76，： | 1 |
| 9 | Ozonation of NOM and algal toxins in four treated waters显示文摘 | Rositano J Newcombe G Nicholson B | 2001 | Water Research2001，35，1： | 1 |
| 10 | Automatic linkage of vital records显示文摘 | NEWCOMBE H B KENNEDY J M AXFORD S J | | 0，，3381： | 1 |
| 11 | Implications of modularity on product design for the life cycle 显示文摘 | NEWCOMB P J BRAS B ROSEN D W | 1998 | Journal of Mechanical Design Transactions of the ASME1998，120，3： | 1 |
| 12 | PCR of peripheral blood for diagnosis of meningococcal disease 显示文摘 | Newcombe J Cartwright K Palmer WH | 1996 | J Clin Microbiol1996，34，7： | 1 |
| 13 | Discovery of aminoquinazolines as potent,orally bioavailable inhib-itors of Lck: Synthesis, SAR, and in vivo anti-inflanunato- ry activity显示文摘 | Dimauro E F Newcomb J Nunes J J | 2006 | J Med Chem2006，49，： | 1 |
| 14 | The metabolism of a city:the case of Hong Kong显示文摘 | Newcombe K Kalina J D Aston A R | 1978 | AMBIO1978，，7： | 1 |
| 15 | Expansion and contraction of the Sahara desert from 1980 to 1990显示文摘 | Tucker C J Dregne H E Newcomb W W | 1991 | Science1991，253，： | 1 |
| 16 | Cellulase, clostfidia, and ethanol 显示文摘 | Demain A L Newcomb M Wu J H D | 2005 | Microbiol Mol Biol R2005，69，： | 1 |
| 17 | The lysine requirement of lactating primiparous sows显示文摘 | Touchette K J Allee G L Newcomb M D | 1998 | Journal of Animal Science1998，76，： | 1 |
| 18 | Extraction and proteomic analysis of proteins from normal and multiple sclerosis postmortem brain显示文摘 | Newcombe J Eriksson B Ottervald J | 2005 | J Chromatog B2005，815，12： | 1 |
| 19 | Discovery of aminoquin- azolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti -inflammatory activity 显示文摘 | DiMauro E F Newcomb J Nunes J J | 2006 | J Med Chem2006，49，19： | 1 |
| 20 | Astrocyte characterization in themultiple sclerosis glial scar显示文摘 | Holley JE Gveric D Newcombe J | 2003 | Neuropathol Appl Neurobiol2003，29，5： | 1 |
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