|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Microbiota-host interactions in irritable bowel syndrome: Epithelial barrier, immune regulation and brain-gut interactions显示文摘Irritable bowel syndrome(IBS) is a common, sometimes debilitating, gastrointestinal disorder worldwide. While altered gut motility and sensation, as well as aberrant brain perception of visceral events, are thought to contribute to the genesis of symptoms in IBS, a search for an underlying aetiology has, to date, proven unsuccessful. Recently, attention has been focused on the microbiota as a possible factor in the pathogenesis of IBS. Prompted by a number of clinical observations, such as the recognition of the de novo development of IBS following enteric infections, as well as descriptions of changes in colonic bacterial populations in IBS and supported by clinical responses to interventions, such as antibiotics and probiotics, that modify the microbiota, various approaches have been taken to investigating the microbiota-host response in IBS, as well as in animal models thereof. From such studies a considerable body of evidence has accumulated to indicate the activation or upregulation of both factors involved in bacterial engagement with the host as well host defence mechanisms against bacteria. Alterations in gut barrier function, occurring in response, or in parallel, to changes in the microbiota, have also been widely described and can be seen to play a pivotal role in generating and sustaining host immune responses both within and beyond the gut. In this manner a plausible hypothesis, based on an altered microbiota and/or an aberrant host response, for the pathogenesis, of at least some instances of IBS, can be generated. | Niall P Hyland Eamonn MM Quigley Elizabeth Brint | 2014 | World Journal of Gastroenterology2014，20，27： | 22 |
| 2 | Establishing proof of concept:Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus显示文摘Osteochondral lesions of the talus are common injuries in the athletic patient. They present a challenging clinical problem as cartilage has a poor potential for healing. Current surgical treatments consist of reparative(microfracture) or replacement(autologous osteochondral graft) strategies and demonstrate good clinical outcomes at the short and medium term follow-up. Radiological findings and second-look arthroscopy however, indicate possible poor cartilage repair with evidence of fibrous infill and fissuring of the regenerative tissue following microfracture. Longer-term follow-up echoes these findings as it demonstrates a decline in clinical outcome. The nature of the cartilage repair that occurs for an osteochondral graft to become integrated with the native surround tissue is also of concern. Studies have shown evidence of poor cartilage integration,with chondrocyte death at the periphery of the graft, possibly causing cyst formation due to synovial fluid ingress. Biological adjuncts, in the form of platelet-rich plasma(PRP) and bone marrow aspirate concentrate(BMAC), have been investigated with regard to their potential in improving cartilage repair in both in vitro and in vitro settings. The in vitro literature indicates that these biological adjuncts may increase chondrocyte proliferation as well as synthetic capability, while limiting the catabolic effects of an inflammatory joint environment. These findings have been extrapolated to in vitro animal models, with results showing that both PRP and BMAC improve cartilage repair. The basic science literature therefore establishes the proof of concept that biological adjuncts may improve cartilage repair when used in conjunction with reparative and replacement treatment strategies for osteochondral lesions of the talus. | Niall A Smyth Christopher D Murawski Amgad M Haleem Charles P Hannon Ian Savage-Elliott John G Kennedy | 2012 | World Journal of Orthopedics2012，3，7： | 8 |
| 3 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 4 | Football injuries of the ankle: A review of injury mechanisms, diagnosis and management显示文摘Football is the most popular sport worldwide and is associated with a high injury rate, most of which are the result of trauma from player contact. Ankle injuries are among the most commonly diagnosed injuries in the game. The result is reduced physical activity and endurance levels, lost game time, and considerable medical cost. Sports medicine professionals must employ the correct diagnostic tools and effective treatments and rehabilitation protocols to minimize the impact of these injuries on the player. This review examines the diagnosis, treatment, and postoperative rehabilitation for common football injuries of the ankle based on the clinical evidence provided in the current literature. | Raymond J Walls Keir A Ross Ethan J Fraser Christopher W Hodgkins Niall A Smyth Christopher J Egan James Calder John G Kennedy | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 5 | Gastrointestinal perforation in metastatic colorectal cancer patients with peritoneal metastases receiving bevacizumab显示文摘AIM:To investigate the safety and efficacy of adding bevacizumab to first-line chemotherapy in metastatic colorectal cancer patients with peritoneal disease.METHODS:We compared rates of gastrointestinal perforation in patients with metastatic colorectal cancer and peritoneal disease receiving first-line chemotherapy with and without bevacizumab in three distinct cohorts:(1) the AGITG MAX trial(Phase Ⅲ randomised clinical trial comparing capecitabine vs capecitabine and bevacizumab vs capecitabine,bevacizumab and mitomycin C);(2) the prospective Treatment of Recurrent and Advanced Colorectal Cancer(TRACC) registry(any first-line regimen ± bevacizumab);and(3) two cancer centres in New South Wales,Australia [Macarthur Cancer Therapy Centre and Liverpool Cancer Therapy Centre(NSWCC) from January 2005 to Decenber 2012,(any first-line regimen ± bevacizumab).For the AGITG MAX trial capecitabine was compared to the other two arms(capecitabine/bevacizumab and capecitabine/bevacizumab/mitomycin C).In the AGITG MAX trial and the TRACC registry rates of gastrointestinal perforation were also collected in patients who did not have peritoneal metastases.Secondary endpoints included progression-free survival,chemotherapy duration,and overall survival.Time-toevent outcomes were estimated using the Kaplan-Meier method and compared using the log-rank test.RESULTS:Eighty-four MAX,179 TRACC and 69 NSWCC patients had peritoneal disease.There were no gastrointestinal perforations recorded in either the MAX subgroup or the NSWCC cohorts.Of the patients without peritoneal disease in the MAX trial,4/300(1.3%) in the bevacizumab arms had gastrointestinal perforations compared to 1/123(0.8%) in the capecitabine alone arm.In the TRACC registry 3/126(2.4%) patients who had received bevacizumab had a gastrointestinal perforation compared to 1/53(1.9%) in the chemotherapy alone arm.In a further analysis of patients without peritoneal metastases in the TRACC registry,the rate of gastrointestinal perforations was 9/369(2.4%) in the chemotherapy/bevacizumab group and 5/177(2.8%) in the chemotherapy alone group.The addition of bevacizumab to chemotherapy was associated with improved progression-free survival in all three cohorts:MAX 6.9 m vs 4.9 m,HR = 0.64(95%CI:0.42-1.02);P = 0.063;TRACC 9.1 m vs 5.5 m,HR = 0.61(95%CI:0.37-0.86);P = 0.009;NSWCC 8.7 m vs 6.8 m,HR = 0.75(95%CI:0.43-1.32);P = 0.32.Chemotherapy duration was similar across the groups.CONCLUSION:Patients with peritoneal disease do not appear to have an increased risk of gastrointestinal perforations when receiving first-line therapy with bevacizumab compared to systemic therapy alone. | Aflah Roohullah Hui-Li Wong Katrin M Sjoquist Peter Gibbs Kathryn Field Ben Tran Jeremy Shapiro Joe Mckendrick Desmond Yip Louise Nott Val Gebski Weng Ng Wei Chua Timothy Price Niall Tebbutt Lorraine Chantrill | 2015 | World Journal of Gastroenterology2015，21，17： | 3 |
| 6 | Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study显示文摘AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid(TXA) in lower limb arthroplasty.METHODS: This study evaluates the use of TXA in 200 consecutive lower limb arthroplasties performed in a single surgeon series. The initial 100 patients(control group) underwent surgery without perioperative administration of TXA while the subsequent 100 patients(TXA group) all received 1 g TXA at the time of induction of anaesthesia. Pre- and post-operative haemoglobin, platelet count, haematocrit, the use of blood product post-operatively, length of stay were examined. A financial analysis of both groups was then undertaken. RESULTS: The mean age of patients in both groups was 63 ± 13 years. There were no significant differences between groups in terms of gender(P = 0.47), proportion of total hip replacement to total knee replacement(P = 0.25) or pre-operative haemoglobin(P = 0.43). In the control group, the transfusion rate was 22%. In the TXA group, the transfusion rate dropped to 2%(P < 0.001). The mean post-operative haemoglobin was 10.82 ± 1.55g/dL in the control group vs 11.33 ± 1.27 g/dL in the TXA group(P = 0.01). The total cost of transfused blood products was €11055 and €603 respectively. The mean length of stay in the control group was 6.53 ± 5.93 d vs 5.47 ± 4.26 d in the TXA group(P = 0.15) leading to an estimated financial saving of €114586. There was one pulmonary embolus in the control group and one deep venous thrombosis in the TXA group.CONCLUSION: Intravenous TXA reduces blood loss in lower limb arthroplasty. This leads to lower transfusion rates, shorter length of stay in hospital and significant financial savings. | Niall P McGoldrick Eabhann M O'Connor Nikos Davarinos Rose Galvin John F Quinlan | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 7 | Bevacizumab in Combination With Chemotherapy As First-Line Therapy in Advanced Gastric Cancer: A Biomarker Evaluation From the AVAGAST Randomized Phase III Trial显示文摘 | Eric Van Cutsem Sanne de Haas Yoon-Koo Kang Atsushi Ohtsu Niall C. Tebbutt Jian Ming Xu Wei Peng Yong Bernd Langer Paul Delmar Stefan J. Scherer Manish A. Shah | 2012 | Journal of Clinical Oncology2012，，17： | 3 |
| 8 | Magnetic ferrite/carbonized cotton fiber composites for improving electromagnetic absorption properties at gigahertz frequencies显示文摘Ferrite/carbon composited materials,especially the bio-derived composited materials possessing both environmental friendliness and outstanding microwave absorption performance,attract numerous attentions for solving the'electromagnetic problem'in the Gigahertz frequency range.In this work,we demonstrate a bio-derived ferrite/carbon material by compositing functional carbonized cotton fibers(CCFs)and Fe_(3)O_(4)nanoparticles with optimized microwave-absorption properties.By adjusting the carbonization conditions systematically,the Fe_(3)O_(4)loading contents and the microwave absorption properties can be varied simultaneously-and,indeed,optimized and tuned.The CCFs-Fe_(3)O_(4)composites exhibited a minimum reflection-loss capacity RL(d B)of-56.8 d B at 10.9 GHz with a thickness of 1.67 mm,and its effective absorption bandwidth(RL(d B)<-20 d B)was found to broaden to 7.1 GHz.Electromagnetic characterizations,coupled with microstructure analyses,revealed that the enhancement in microwave absorption was triggered by the different microstructures of CCFs-Fe_(3)O_(4)composites-attributable to the different carbonization processes.These different conditions result in different amounts of Fe_(3)O_(4)attachment sites and lead to the enhancement of dielectric polarization at localized microstructures.The present work of bio-derived ferrite/carbon materials has important implications in understanding structure-performance relationships in dielectric-magnetic materials,and,meanwhile,could well be extended to a microwave-absorber design approach. | Sateesh Bandaru Narashima Murthy Ravindra Kulkarni Niall J.English | 2021 | Journal of Materials Science & Technology2021，，27： | 2 |
| 9 | Quality of life issues in men undergoing androgen deprivation therapy: a review显示文摘雄激素剥夺治疗(ADT ) 是为治疗前列腺癌症(PCa ) 的一种必要治疗选择。为神经质的治疗的角色开始被限制为人与变形、不能实行,局部地先进的疾病。现在,它为外科和放射疗法被扩大了到 neoadjuvant 或辅助治疗,为在外科或放射以后的生物化学的恶化,并且为非变形的疾病弄平同样主要的治疗。对待的百分之五十个 PCa 病人将在某点收到 ADT。关于与更普遍的 ADT 使用联系的不利效果和费用正在种担心。生活(QoL ) 的质量上的不利效果,当人们是剥夺雄激素的时,包括物理、社会、心理的健康,可能可观。这评论在下列区域检验 QoL 问题:身体女性化,性变化,关系变化,认知、感情方面的症状,疲劳,睡觉骚乱,消沉和物理效果。推进建议因为减少这些改变的治疗学的途径被建议。 | Rowan G Casey Niall M Corcoran S Larry Goldenberg | 2012 | Asian Journal of Andrology2012，14，2： | 2 |
| 10 | LOV to BLUF: Flavoprotein Contributions to the Optogenetic Toolkit显示文摘Optogenetics 是联合光、基因的途径 non-invasively 与优美空间与时间的控制防碍细胞的事件的一块新兴的地。尽管它从神经科学原来产生了, optogenetics 对许多不同生物系统的学习广泛地适用,从这种技术产生的应用程序的范围继续增加。而且,使用设计新 optogenetic 工具的光敏感的蛋白质的全部剧目很快正在膨胀。察觉到的光,氧,或电压和 Blue-Light-Utilizing 黄素腺嘌 dinucleotide (一度时髦的风尚)(BLUF )(LOV ) 领域代表新贡献者到 optogenetic 工具箱。这些小(100140-amino 酸) 黄素蛋白模块从对 UV-A/blue 光作出回应的植物和细菌的光敏电阻器被导出。在最近的年里,可观的进步在揭开被成为了 LOV 和 BLUF 领域的 photoactivation 机制。这知识在合成 photoswitches 的设计被使用了并且荧光灯有在房间生物学和生物工学的应用的记者。在这评论,我们总结 LOV 和 BLUF photosensors 的光化学的性质并且加亮一些这些黄素蛋白怎么正在被采用人工地调整并且想象的最近的进展许多生物过程。 | John M. Christie Jayde Gawthorne Gillian Young Niall J. Fraser^c and Andrew J. Roe | 2012 | Molecular Plant2012，5，3： | 2 |
| 11 | Testing a model of CO 2 , water and energy exchange in Great Plains tallgrass prairie and wheat ecosystems显示文摘 | Niall P. Hanan Joseph A. Berry Shashi B. Verma Elizabeth A. Walter-Shea Andrew E. Suyker George G. Burba A. Scott Denning | 2005 | Agricultural and Forest Meteorology2005，，3： | 2 |
| 12 | Modelling dynamic spatial processes: simulation of urban future scenarios through cellular automata显示文摘 | José I. Barredo Marjo Kasanko Niall McCormick Carlo Lavalle | 2002 | Landscape and Urban Planning2002，，3： | 2 |
| 13 | Designing User Interface Software for Embedded Systems显示文摘 | Niall Murphy | 2000 | Embedded Systems Conference Papers Spring2000，208，1： | 1 |
| 14 | In vitro growth characteristics of five candidate aquaculture probiotics and two fish pathogens grown in fish intestinal mucus显示文摘 | Niall G V Winston D L Horst K | 2004 | Microbiology Letters2004，231，： | 1 |
| 15 | Just-in-time Purchasing and Supp-ly--a Review of the Literature显示文摘 | Niall W F | 1995 | International Journal of Operations & Production Management1995，15，9： | 1 |
| 16 | Enterocutaneous fistula: Are treatments improving?显示文摘 | John M. Draus Sara A. Huss Niall J. Harty William G. Cheadle Gerald M. Larson | 2006 | Surgery2006，，4： | 1 |
| 17 | An appraisal of lymph node ratio in colon and rectal cancer: not one size fits all显示文摘 | M. Medani Niall Kelly George Samaha G. Duff Vourneen Healy Elizabeth Mulcahy Eoghan Condon David Waldron Jean Saunders J. Calvin Coffey | 2013 | International Journal of Colorectal Disease2013，，10： | 1 |
| 18 | Plasma fibrinogen and serum C-reactive protein are associated with non-small cell lung cancer 显示文摘 | Mark J Niall C McGonigle | 2006 | Lung Cancer2006，53，1： | 1 |
| 19 | A Comparison of Noncontrast Computerized Tomography with Excretory Urography in the Assessment of Acute Flank Pain显示文摘 | Niall O Russell J Macgregor R | 1999 | J Urol1999，161，2： | 1 |
| 20 | Segmental necrotizing glomerulonephritis with antineutrophil antibody:possible arbovirus aetiology显示文摘 | Davies DJ Moran JE Niall JF Ryan GB | | 0，，6342： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员