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| 1 | Leptin, cardiovascular diseases and type 2 diabetes mellitus显示文摘Leptin,经由胃口抑制在食物吸入的控制被含有的 adipokine,可以也刺激氧化应力,发炎,血栓,动脉的僵硬, angiogenesis 和 atherogenesis。这些导致 leptin 的效果可以预先安排到心血管的疾病的发展。在现在的评论,我们讨论与两个的存在,严厉或预后连接 leptin 层次的证据冠的动脉疾病和非心脏的脉管的疾病象中风那样,颈动脉动脉疾病,外部动脉疾病(垫)和象与长期的肾疾病( CKD )和类型一样的腹的大动脉的动脉瘤( AAA ) 2 糖尿病 mellitus ( T2DM )。Leptin 层次断然与存在,严厉,程度和冠的动脉粥样硬化以及与存在,严厉和 ischemic 和出血性的击的差的临床的结果的损害复杂性被联系了。但是冲突结果也存在。而且, leptin 被报导独立地预言普通颈动脉 intima 媒介厚度和颈动脉匾不稳定性。在 hyperleptinemia 和垫之间的一个连接被报导了,而有限数据在在 leptin 和 AAA 之间的潜在的协会上是可得到的。提高的 leptin 集中也象与胰岛素抵抗一样与 CKD 发生和前进有关, T2DM,微 -- 并且 macrovascular 糖尿病患者复杂并发症。Statins 和 antidiabetic 药(包括的 sitagliptin, metformin, pioglitazone, liraglutide 和 empagliflozin ) 可以影响 leptin 层次。进一步的研究被需要建立潜在的使用(如果任何) 是的 leptin 在这些疾病的一个治疗学的目标。 | Niki KATSIKI Dimitri P MIKHAILIDIS Maciej BANACH | 2018 | Acta Pharmacologica Sinica2018，39，7： | 41 |
| 2 | Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome显示文摘AIM: To investigate the effect of rosuvastatin monotherapy on non-alcoholic steatohepatitis(NASH). At present there is no effective treatment for non-alcoholic fatty liver disease or its advanced form NASH.METHODS: This prospective study included 20 biopsy proven patients with NASH, metabolic syndrome(Met S) and dyslipidaemia. Biochemical parameters of the blood of the patients and an ultrasonography of the liver were performed at baseline. Then patients receivedlifestyle advice and were treated for a 12 mo period with rosuvastatin(10 mg/d) monotherapy. Patients were re-evaluated during the study at 3 mo intervals, during which biochemical parameters of the blood were measured including liver enzymes. A repeat biopsy and ultrasonography of the liver were performed at the end of the study in all 20 patients. Changes in liver enzymes, fasting plasma glucose, serum creatinine, serum uric acid(SUA), high sensitivity C reactive protein(hs CRP) and lipid profile were assessed every 3 mo. The primary endpoint was the resolution of NASH and the secondary endpoints were the changes in liver enzyme and lipid values.RESULTS: The repeat liver biopsy and ultrasonography showed complete resolution of NASH in 19 patients, while the 20 th, which had no improvement but no deterioration either, developed arterial hypertension and substantial rise in triglyceride levels during the study, probably due to changes in lifestyle including alcohol abuse. Serum alanine transaminase, aspartate transaminase, and γ-glutamyl transpeptidase were normalised by the 3rd treatment month(ANOVA P < 0.001), while alkaline phosphatase activities by the 6th treatment month(ANOVA, P = 0.01). Fasting plasma glucose and glycated haemoglobin were significantly reduced(P < 0.001). Lipid values were normalised by the 3rd treatment month. No patient had Met S by the 9th treatment month. Body mass index and waist circumference remained unchanged during the study. Thus, changes in liver pathology and function should be attributed solely to rosuvastatin treatment. A limitation of the study is the absence of a control group.CONCLUSION: These findings suggest that rosuvastatin monotherapy could ameliorate biopsy proven NASH and resolve Met S within 12 mo. These effects and the reduction of fasting plasma glucose and SUA levels may reduce the risk of vascular and liver morbidity and mortality in NASH patients. These findings need confirmation in larger studies. | Konstantinos Kargiotis Vasilios G Athyros Olga Giouleme Niki Katsiki Evangelia Katsiki Panagiotis Anagnostis Chrysoula Boutari Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，21，25： | 18 |
| 3 | Cytopathologic diagnosis of fine needle aspiration biopsies of thyroid nodules显示文摘Fine-needle aspiration(FNA) cytology is an important diagnostic tool in patients with thyroid lesions.Several systems have been proposed for the cyropathologic diagnosis of the thyroid nodules.However cases with indeterminate cytological findings still remain a matter of debate.In this review we analyze all literature regarding Thyroid Cytopathology Reporting systems trying to identify the most suitable methodology to use in clinical practice for the preoperative diagnosis of thyroid nodules.A review of the English literature was conducted,and data were analyzed and summarized and integrated from the authors' perspective.The main purpose of thyroid FNA is to identify patients with higher risk for malignancy,and to prevent unnecessary surgeries for benign conditions.The Bethesda System for Reporting Thyroid Cytopathology is the most widely used system for the diagnosis of thyroid FNA specimens.This system also contains guidelines for the diagnosis and treatment of indeterminate or suspicious for malignancy cases.In conclusion,patients who require repeated FNAs for indeterminate diagnoses will be resolved by repeat FNA in a percentage of 72%-80%. | Evangelos P Misiakos Niki Margari Christos Meristoudis Nickolas Machairas Dimitrios Schizas Konstantinos Petropoulos Aris Spathis Petros Karakitsos Anastasios Machairas | 2016 | World Journal of Clinical Cases2016，4，2： | 12 |
| 4 | Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease:an update显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Niki Katsiki Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，，22： | 2 |
| 5 | Comparative tolerability of the newer fluoroquinolone antibacterials显示文摘 | Ball P Mandell L Niki Y | 1999 | Dr- ug Saf1999，21，5： | 1 |
| 6 | Trichostatin A,a histone deacetylase inhibitor,suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesisin skin fibroblasts显示文摘 | Rombouts K Niki T Greenwel P | 2002 | Exp Cell Res2002，278，2： | 1 |
| 7 | Trust and conflict within virtual inter-organizational alliances: A framework for facilitating knowledge sharing 显示文摘 | Niki P Siva S | 2005 | Decision Support Systems2005，39，4： | 1 |
| 8 | Transforming growth factor-β gene expression in normal and fibrotic rat liver显示文摘 | DE BLESER P J NIKI T ROGIERS V | 1987 | Hepatol1987，26，： | 1 |
| 9 | Galen on syncope显示文摘 | Niki P Dimitrios T | 2010 | Int J Cardiol2010，142，3： | 1 |
| 10 | Effect of various treatments on leptin, adiponectin, ghrelin and neuropeptide Y in patients with type 2 diabetes mellitus显示文摘 | Niki Katsiki Dimitri P Mikhailidis Anna Gotzamani-Psarrakou John G Yovos Dimitrios Karamitsos | 2011 | Expert Opinion on Therapeutic Targets2011，，4： | 1 |
| 11 | The effect of posteriortibial tendon dysfunction on hindfoot kinematics显示文摘 | Niki H Ching RP Kiser P | 2001 | FootAnkle Int2001，22，4： | 1 |
| 12 | Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts显示文摘 | Rombouts K Niki T Greenwel P | 2002 | Exp Cell Res2002，278，2： | 1 |
| 13 | Comparative tolerability of the newer fluoroquinolone antibacterials显示文摘 | Ball P Mandell L Niki Y | 1999 | Drug Saf1999，21，5： | 1 |
| 14 | ZnO growth on Si by radical source MBE显示文摘 | Lwata K Fons P Niki S | 2000 | J Cryst Growth2000，，： | 1 |
| 15 | FTIR spectroscopic study of the mechanism for the gas-phase reaction between ozone and tetramethylethylene显示文摘 | Niki H Maker P D Savage C M | | 0，，04： | 1 |
| 16 | A histone deacetylase inhibitor,trichostatin A,suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture显示文摘 | Niki T Rombouts K De-Bleser P | 1999 | Hepatology1999，29，3： | 1 |
| 17 | Comparison of glial fibrillary acidic protein and desmin staining in normal and CCl4-induced fibrotic rat liver显示文摘 | Niki T de Bleser P J Xu G | 1996 | Hepatology1996，23，6： | 1 |
| 18 | 显示文摘 | Iwata K Fons P Niki S | 2000 | J Crystal Growth2000，，： | 1 |
| 19 | Elaboration and Characterization of Sol-gel Derived ZrO2 Thin Films Treated with Hot Water显示文摘 | Mun T S Niki P Atsunori M | 2012 | Applied SuoCace Science2012，258，： | 1 |
| 20 | Comparative tolerability of the newer fluoroquinolone antibacterials显示文摘 | Ball P Mandell L Niki Y | 1999 | Drug Saf1999，，： | 1 |
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