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| 1 | Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers显示文摘Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence rates.Today,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets.Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers.Over the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such patients.Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further exploration.OPN signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver cancers.This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver cancers.Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies. | Dong-Xing Cao Zhi-Jie Li Xiao-Ou Jiang Yick Liang Lum Ester Khin Nikki P Lee Guo-Hao Wu John M Luk | 2012 | World Journal of Gastroenterology2012，18，30： | 29 |
| 2 | Dickkopfs and Wnt/β-catenin signalling in liver cancer显示文摘Liver cancer is the fifth and seventh most common cause of cancer in men and women,respectively.Wnt/β-catenin signalling has emerged as a critical player in both the development of normal liver as well as an oncogenic driver in hepatocellular carcinoma(HCC).Based on the current understanding,this article summarizes the possible mechanisms for the aberrant activation of this pathway with specific focus on HCC.Furthermore,we will discuss the role of dickkopfs(DKKs)in regulating Wnt/β-catenin signalling,which is poorly understood and understudied.DKKs are a family of secreted proteins that comprise at least four members,namely DKK1-DKK4,which act as inhibitors of Wnt/β-catenin signalling.Nevertheless,not all members antagonize Wnt/β-catenin signalling.Their functional significance in hepatocarcinogenesis remains to be further characterized for which these studies should provide new insights into the regulatory role of DKKs in Wnt/β-catenin signalling in hepatic carcinogenesis.Because of the important oncogenic roles,there are an increasing number of therapeutic molecules targetingβ-catenin and the Wnt/β-catenin pathway for potential therapy of HCC. | Sarwat Fatima Nikki P Lee John M Luk | 2011 | World Journal of Clinical Oncology2011，2，8： | 11 |
| 3 | Hepatic tight junctions:From viral entry to cancer metastasis显示文摘The tight junction (TJ) is a critical cellular component for maintenance of tissue integrity, cellular interactions and cell-cell communications, and physiologically functions as the 'great wall' against external agents and the surrounding hostile environment. During the host-pathogen evolution, viruses somehow found the key to unlock the gate for their entry into cells and to exploit and exhaust the host cells. In the liver, an array of TJ molecules is localized along the bile canaliculi forming the blood-biliary barrier, where they play pivotal roles in paracellular permeability, bile secretion, and cell polarity. In pathology, certain hepatic TJ molecules mediate virus entry causing hepatitis infection; deregulation and functional abnormality of the TJ have also been implicated in triggering liver cancer development and metastasis. All these findings shed new insights on the understanding of hepatic TJs in the development of liver disease and provide new clues for potential intervention. | Nikki P Lee John M Luk | 2010 | World Journal of Gastroenterology2010，16，3： | 4 |
| 4 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 5 | Acute myocardial infarction complicated by respiratory failure,the effects of mechanical ventilation显示文摘 | Rasanen J Nikki P Heikkila J | 1984 | Chest1984，85，1： | 1 |
| 6 | Extubation criteria after weaning from intermittent mandatory ventilation and continuous positive airway pressure显示文摘 | Salmenpera M Nikki P | 1983 | Crit Care Med1983，11，3： | 1 |
| 7 | Extubation criteria after weaning from intermittent mandatory ventilation and continuous positive airway pressure显示文摘 | Tahvanainen J Salmenpera M Nikki P | 1983 | Cfit Care Med1983，11，： | 1 |
| 8 | Ptosis following periocular or general anaesthesia in cataract surgery显示文摘 | Ropo A Ruusuvaara P Nikki P | 1992 | Acta Ophthalmol (Copenh)1992，70，2： | 1 |
| 9 | Aortoiliac Icsufficiency:Long-term Experience with Stent Placement for Treatment显示文摘 | Timothy P Murphy MD Nikki S Ariaratnam BA Wilfred I Carney | 2004 | Radiology2004，，231： | 1 |
| 10 | Brain cyclic- AMP and possible mechansims of cerebrovascular dilation by anesthetics in rats 显示文摘 | Macmurdo SD Nemoto EM Nikki P | 1981 | Anesthesiology1981，55，7： | 1 |
| 11 | Circulating markers for prognosis of hepatocellular carcinoma显示文摘 | Kwong-Fai Wong Zhi Xu Jinfei Chen Nikki P Lee John M Luk | 2013 | Expert Opinion on Medical Diagnostics2013，，4： | 1 |
| 12 | Brain cyclic-AMP and possible mechansims of cerebrovascular dilation by anesthetics in rats显示文摘 | Macmurdo S D Nemoto E M Nikki P | 1981 | Anesthesiology1981，55，： | 1 |
| 13 | Brain cyclicAMP and possible mechansims of cerebrovascular dilation by anesthetics in rats显示文摘 | Macmurdo SD Nemoto EM Nikki P | 1981 | Anesthesiology1981，55，： | 1 |
| 14 | Extubation criteria after weaning from intermittent mandatory ventilation and continuous positive airway pressure显示文摘 | Tahavanainen J Salmenpera M Nikki P | 1983 | Crit Care Med1983，11，9： | 1 |
| 15 | Effect of pentazocine and pethidine on plasma catecholamine levels显示文摘 | Tammisto T Jaattela A Nikki P | 1997 | Annals of clinical research1997，3，1： | 1 |
| 16 | Resection of the pancreas for acute fulminant pancreatitis显示文摘 | Kivilaakso E Fraki O Nikki P | 1981 | Surg Gynecol Obstet1981，152，4： | 1 |
| 17 | Extubation criteria after weaning from intermittent mandatory ventilation and eontintmns positive airway pressm~ 显示文摘 | Tahvanainen J Salmenper~i M Nikki P | 1983 | Crit Care Med1983，11，9： | 1 |
| 18 | Nitric oxide/nitric oxide synthase,spermatogenesis,and tight junction dynamics显示文摘 | Nikki P Y Lee C Yan C | 2004 | Biol Reprod2004，70，： | 1 |
| 19 | Brain cyclic- AMP and possible mechansims of cerebrovascular dilation by anesthetics in rats显示文摘 | Macmurdo SD Nemoto EM Nikki P | 1981 | Anesthesiology1981，55，： | 1 |
| 20 | Brain cyclic-AMP and possible mechansims of cerebrovascular dilation by anesthetics in rats显示文摘 | Macmurdo SD Nemoto EM Nikki P | 1981 | Anesthesiology1981，55，： | 1 |
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