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| 1 | Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation:Effects on virus replication and recurrent hepatitis显示文摘瞄准:决定 calcineurin 禁止者, cyclosporine 和 tacrolimus 的效果,在丙肝上,在病人的周期性的丙肝的病毒(HCV ) 复制和活动张贴肝移植。方法:在我们的中心为在 1999 和 2003 之间的联系 HCV 的肝肝硬化收到了肝移植的 107 个病人的一个队的数据回顾地被分析。浆液 HCV-RNA 的水平和周期性的肝炎的活动在作为主要抑制免疫力的代理人和没在移植以后在开始的 12 瞬间以内导致胆汁的复杂并发症的不那样类似的抑制免疫力的政体收到了 cyclosporine 或 tacrolimus 的 47 个病人之间被比较。结果:HCV-RNA 在移植以后在 3 瞬间以内增加了,但是 cyclosporine 组和 tacrolimus 组之间的差别是不足道的(在 12 瞬间的 P=0.49 ) 。另外,由浆液 transaminases 决定了的周期性的肝炎并且门发炎和纤维变性的组织学的分级没在 12 瞬间(P=0.34 ) 以后显示出有效差量。结论:一个主要抑制免疫力的代理人不在肝移植以后在感染 HCV 的病人影响周期性的肝炎的正式就职或严厉的 Cyclosporine 或 tacrolimus。 | Philip Hilgard Alisan Kahraman Nils Lehmann Cornelia Seltmann Susanne Beckebaum R Stefan Ross Hideo A Baba Massimo Malago Christoph E Broelsch Guido Gerken | 2006 | World Journal of Gastroenterology2006，12，5： | 235 |
| 2 | Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis显示文摘AIM:To analyze phospholipid profiles in intrahepatic bile from patients with primary sclerosing cholangitis(PSC)and secondary sclerosing cholangitis(SSC).METHODS:Intrahepatic bile specimens collected via endoscopic retrograde cholangiography from 41 patients were analyzed.Fourteen of these patients were diagnosed with PSC,10 with SSC,11 with choledocholithiasis or no identifiable biliary disease,and 6 with cholangiocellular carcinoma(CCC).Bile acid,cholesterol,protein,and bilirubin contents as well as pancreas lipase activity in bile were determined by biochemical methods.Phosphatidylcholine(PC)and lysophosphatidylcholine(LPC)species were quantified using nanoelectrospray ionization tandem mass spectrometry.RESULTS:Bile from all the examined patient groups showed a remarkably similar PC and LPC species composition,with only minor statistical differences.Total biliary PC concentrations were highest in controls(8030±1843 mol/L)and lowest in patients with CCC(1969±981 mol/L)(P=0.005,controls vs SSC and CCC,respectively,P<0.05).LPC contents in bile were overall low(4.2%±1.8%).Biliary LPC/PC ratios and ratios of biliary PC to bilirubin,PC to cholesterol,PC to protein,and PC to bile acids showed no intergroup differences.CONCLUSION:PC and LPC profiles being similar in patients with or without sclerosing cholangitis,these phospholipids are likely not of major pathogenetic importance in this disease group. | Annika Gauss Robert Ehehalt Wolf-Dieter Lehmann Gerhard Erben Karl-Heinz Weiss Yvonne Schaefer Petra Kloeters-Plachky Adolf Stiehl Wolfgang Stremmel Peter Sauer Daniel Nils Gotthardt | 2013 | World Journal of Gastroenterology2013，19，33： | 3 |
| 3 | Plexiform Lesions in Pulmonary Arterial Hypertension显示文摘 | Danny Jonigk Heiko Golpon Clemens L. Bockmeyer Lavinia Maegel Marius M. Hoeper Jens Gottlieb Nils Nickel Kais Hussein Ulrich Maus Ulrich Lehmann Sabina Janciauskiene Tobias Welte Axel Haverich Johanna Rische Hans Kreipe Florian Laenger | 2011 | The American Journal of Pathology2011，，1： | 1 |
| 4 | GNB3 gene 825 TT variant predicts hard coronary events in the population-based Heinz Nixdorf Recall study显示文摘 | Ulrich H. Frey Susanne Moebus Stefan M?hlenkamp Hagen K?lsch Marcus Bauer Nils Lehmann Markus N?then Thomas W. Mühleisen Andreas Stang Raimund Erbel Karl-Heinz J?ckel Jürgen Peters Winfried Siffert | 2014 | Atherosclerosis2014，，2： | 1 |
| 5 | Intravenous Lidocaine After Tracheal Intubation Mitigates Bronchoconstriction in Patients with Asthma显示文摘 | Michael Adamzik Harald Groeben Ramin Farahani Nils Lehmann Juergen Peters | 2007 | Anesthesia & Analgesia2007，，1： | 1 |
| 6 | Secondhand Smoke Exposure and Coronary Artery Calcification among Nonsmoking Participants of a Population-Based Cohort显示文摘 | Peinemann Frank Moebus Susanne Dragano Nico M?hlenkamp Stefan Lehmann Nils Zeeb Hajo Erbel Raimund J?ckel Karl-Heinz Hoffmann Barbara | 2011 | Environmental Health Perspectives2011，，11： | 1 |
| 7 | Prognostic factors for complete debulking in advanced ovarian cancer and its impact on survival. An exploratory analysis of a prospectively randomized phase III study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group (AGO-OVA显示文摘 | Pauline Wimberger Nils Lehmann Rainer Kimmig Alexander Burges Werner Meier Andreas Du Bois | 2007 | Gynecologic Oncology2007，，1： | 1 |
| 8 | Association of bilirubin with coronary artery calcification and cardiovascular events in the general population without known liver disease: the Heinz Nixdorf Recall study显示文摘 | Amir A. Mahabadi Nils Lehmann Stefan M?hlenkamp Hagen K?lsch Marcus Bauer Rainer Schulz Susanne Moebus Karl-Heinz J?ckel Raimund Erbel Gerd Heusch | 2014 | Clinical Research in Cardiology2014，，： | 1 |
| 9 | 气管插管后静脉注射利多卡因可以减轻哮喘患者的支气管收缩显示文摘背景尽管预防性静脉注射利多卡因可以减轻气道对多种吸入刺激的反应性,但是其对哮喘患者插管后气道阻力的影响尚不清楚。本文旨在检验哮喘患者静脉注射利多卡因是否可以减轻插管诱发的支气管收缩。方法30例哮喘患者[年龄49.1±15.9岁(均数±标准差)]在常规麻醉诱导(依托咪酯0.3mg/kg,芬太尼5μg/kg,罗库溴铵0.6mg/kg,50%氧化亚氮)后行气管插管。分别在插管后即刻、5、10和15分钟测定气道阻力。插管后5分钟,静脉注射利多卡因(利多卡因2mg/kg在5分钟内静脉推注,并以3mg·kg^-1·h^-1的速度持续输注10分钟)或生理盐水。结果插管后即刻的气道平均阻力为23±12cmH2O·s·L^-1。注射盐水后气道阻力进一步增加38%,但是注射利多卡因后气道阻力较注射前下降(26%,P〈0.004)。结论气管插管后静脉注射利多卡因可以减轻哮喘患者的支气管收缩。 | Michael Mamzik Harald Groeben Ramin Farahani Nils Lehmann Juergen Peters 邱必军(译) 俞卫锋(校) | 2008 | 麻醉与镇痛2008，4，2： | 0 |
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