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| 1 | Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats显示文摘Objective The aim of this study is to investigate the effects of oral cadmium(Cd) ingestion on the pulmonary immune response. Methods Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration(5 and 50 mg/L). Antioxidant enzyme defense(superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor(TNF) and interferon(IFN)-γ, as well as the activity of myeloperoxidase(MPO), nitric oxide(NO), and various cytokines [interleukin(IL)-1β, IL-6, IL-10, and IL-17] were investigated. Results Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. Conclusion The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal. | KULAS Jelena NINKOV Marina TUCOVIC Dina POPOV Aleksandrov Aleksandra UKROPINA Mirela CAKIC MILOSEVIC Maja MUTIC Jelena KATARANOVSKI Milena MIKROV Ivana | 2019 | Biomedical and Environmental Sciences2019，32，7： | 4 |
| 2 | Regeneration of the central nervous system-principles from brain regeneration in adult zebrafish显示文摘Poor recovery of neuronal functions is one of the most common healthcare challenges for patients with different types of brain injuries and/or neurodegenerative diseases.Therapeutic interventions face two major challenges:(1)How to generate neurons de novo to replenish the neuronal loss caused by injuries or neurodegeneration(restorative neurogenesis)and(2)How to prevent or limit the secondary tissue damage caused by long-term accumulation of glial cells,including microglia,at injury site(glial scar).In contrast to mammals,zebrafish have extensive regenerative capacity in numerous vital organs,including the brain,thus making them a valuable model to improve the existing therapeutic approaches for human brain repair.In response to injuries to the central nervous system(CNS),zebrafish have developed specific mechanisms to promote the recovery of the lost tissue architecture and functionality of the damaged CNS.These mechanisms include the activation of a restorative neurogenic program in a specific set of glial cells(ependymoglia)and the resolution of both the glial scar and inflammation,thus enabling proper neuronal specification and survival.In this review,we discuss the cellular and molecular mechanisms underlying the regenerative ability in the adult zebrafish brain and conclude with the potential applicability of these mechanisms in repair of the mammalian CNS. | Alessandro Zambusi Jovica Ninkovic | 2020 | World Journal of Stem Cells2020，12，1： | 3 |
| 3 | Co-expression of the proteinase inhibitors oryzacystatin I and oryzacystatin II in transgenic potato alters Colorado potato beetle larval development显示文摘科罗拉多土豆甲壳虫(CPB;Leptinotarsa decemlineata 说,翘目:Chrysomelidae ) 显示出显著适应性到许多控制措施。尽管 oryzacystatin 我和 II (OCI 和 OCII ) 在控制为食物消化使用半胱氨酸朊酶的害虫有潜力,在土豆的单个 OC 基因的表示展出了一最小或 CPB 健康特点上的没有效果。这研究的目的是在土豆(茄属 tuberosum L.) 检验 coexpressed OCI 和 OCII 的效果 CPB 幼虫上的栽培变种 Desiree, Dragaevka 和 Jelica。CPB 幼虫的朊酶的生长参数,消费率和食物利用,以及活动是 assayed。第二和第三个中间形态幼虫在更高相对的生长和消费比在 nontransformed 叶子喂的幼虫评估的更早、有的转变叶子 molted 上喂了,当食物利用的效率是未受影响的时。相反,消费的叶子的第四中间形态最大值重量获得和数量是大约 20% 为在转基因的土豆上喂的幼虫更低。第三个中间形态幼虫的全部的朊酶活动的分析在 azocasein 水解作用测量的全面解朊的活动揭示了减小,在土豆的摄取离开以后,与半胱氨酸朊酶活动 24 h 的抑制伴随了表示 OCI 和 OCII。然而,在在转变叶子的长期的喂以后,幼虫的解朊的活动变得类似于控制。尽管在 OCI/OCII 叶子喂没影响幼虫的幸存, OC 基因的 coexpression 减少了发展时间并且显著地因此减少了 CPB 幼虫引起的植物损坏。 | Aleksandar Cingel Jelena Savic Jelica Lazarevic Tatjana Cosic Martin Raspor Ann Smigocki Slavica Ninkovic | 2017 | Insect Science2017，24，5： | 3 |
| 4 | Pulmonary Immune Responses to Aspergillus Fumigatus in Rats显示文摘Objective To evaluate immunologic mechanisms underlying Aspergillus fumigatus pulmonary infections in immunocompetent Dark Agouti(DA) and Albino Oxford(AO) rats recognized as being susceptible to some inflammatory diseases in different manners. Methods Lung fungal burden(quantitative colony forming units, CFU, assay), leukocyte infiltration(histology, cell composition) and their function(phagocytosis, oxidative activity, CD11 b adhesion molecule expression) and cytokine interferon-γ(IFN-γ) and interleukin-17 and-4(IL-17 and IL-4) lung content were evaluated following infection(intratracheally, 1x107 conidia). Results Slower reduction of fungal burden was observed in AO rats in comparison with that in DA rats, which was coincided with less intense histologically evident lung cell infiltration and leukocyte recovery as well as lower level of most of the their activities including intracellular myeloperoxidase activity, the capacity of nitroblue tetrazolium salt reduction and CD11 b adhesion molecule expression(except for phagocytosis of conidia) in these rats. Differential patterns of changes in proinflammatory cytokine levels(unchanged levels of IFN-γ and transient increase of IL-17 in AO rats vs continuous increase of both cytokines in DA rats) and unchanged levels of IL-4 were observed. Conclusion Genetically-based differences in the pattern of antifungal lung leukocyte activities and cytokine milieu, associated with differential efficiency of fungal elimination might be useful in the future use of rat models in studies of pulmonary aspergillosis. | MIRKOV Ivana EL-MUZGHI Amal Atia Mhfuod DJOKIC Jelena NINKOV Marina POPOV ALEKSANDROV Aleksandra GLAMOCLIJA Jasmina KATARANOVSKI Milena | 2014 | Biomedical and Environmental Sciences2014，27，9： | 2 |
| 5 | Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions显示文摘Precise tuning of gene expression,accomplished by regulato ry networks of transcription factors,epigenetic modifiers,and microRNAs,is crucial for the proper neural development and function of the brain cells.The SOX transcription factors are involved in regulating diverse cellular processes during embryonic and adult neurogenesis,such as maintaining the cell stemness,cell prolife ration,cell fate decisions,and terminal diffe rentiation into neurons and glial cells.MicroRNAs represent a class of small non-coding RNAs that play important roles in the regulation of gene expression.Together with other gene regulatory factors,microRNAs regulate different processes during neurogenesis and orchestrate the spatial and temporal expression important for neurodevelopment.The emerging data point to a complex regulatory network between SOX transcription factors and microRNAs that govern distinct cellular activities in the developing and adult brain.Deregulated SOX/mic roRNA interplay in signaling pathways that influence the homeostasis and plasticity in the brain has been revealed in various brain pathologies,including neurodegenerative disorders,traumatic brain injury,and cancer.Therapeutic strategies that target SOX/microRNA interplay have emerged in recent years as a promising tool to target neural tissue regeneration and enhance neuro restoration.N umerous studies have confirmed complex intera ctions between microRNAs and SOX-specific mRNAs regulating key features of glioblastoma.Keeping in mind the crucial roles of SOX genes and microRNAs in neural development,we focus this review on SOX/microRNAs interplay in the brain during development and adulthood in physiological and pathological conditions.Special focus was made on their interplay in brain pathologies to summarize current knowledge and highlight potential future development of molecular therapies. | Milena Stevanovic Danijela Stanisavljevic Ninkovic Marija Mojsin Danijela Drakulic Marija Schwirtlich | 2022 | Neural Regeneration Research2022，17，11： | 2 |
| 6 | Cytochrome C oxidase activity and total glutathione content in experimental model of intracerebral aluminum overload显示文摘 | Jovanovic M D Ninkovic M Malicevic Z | 2000 | Vojnosanit Pregl2000，57，3： | 2 |
| 7 | Anterior neck reconstruction with preexpander free groin and scapular flaps显示文摘 | NINKOVIC M MOSER R A | 2004 | Plast Reconstr Sury2004，113，： | 1 |
| 8 | Immunology of O-glycosylated proteins:approaches to the design of a MUC1 glycopeptide-based tumor vaccine显示文摘 | Hanisch FG Ninkovic T | 2006 | Curr Protein Pept Sci2006，7，4： | 1 |
| 9 | Simulation ofpractical single-pixel wire-grid polarizers for superpixelstokes vector imaging arrays 显示文摘 | Raisanen A D Presnar M D Ninkov Z | 2012 | Optical Engineering2012，51，01： | 1 |
| 10 | The zebrafish as a model system for assessing the reinforcingn properties of drugs of abuse显示文摘 | NINKOVIC J BALLY-CUIF L | 2006 | Methods2006，39，3： | 1 |
| 11 | Stereoselective synthesis of (-)-α-Kainic acid and (+)-α-alloKainic acid via trimethylstannyl-nediated radical carbocyclization and oxidative destannylation显示文摘 | Hanessian S Ninkovic S | 1996 | The Journal of Organic Chemistry1996，61，16： | 1 |
| 12 | Foraging in a complex environment-semioehemicals sup- port searching behaviour of the seven spot ladybird 显示文摘 | PETTERSSON J NINKOVIC V GLINWOOD R | 2005 | European Journal of Entomology2005，102，： | 1 |
| 13 | Volatile communication between barley plantsaffects biomass allocation显示文摘 | Ninkovic V | 2003 | Journal of ExperimentalBotany2003，54，389： | 1 |
| 14 | Anew approach to per-sistant traumatic peroneal nerve palsy 显示文摘 | Ninkovic M Sueur D Strarovic B | 1994 | BritishJournal of Plastic Surgery1994，47，3： | 1 |
| 15 | Two-photon excitation and luminescence of a CaWO4 scintillator显示文摘 | MIKHAILIK V B BAILIFF I K KRAUS H RODNYI P A NINKOVIC J | 2004 | Radiat Measur2004，38，： | 1 |
| 16 | Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent in- hibitor of PI3Kalpha and mTOR 显示文摘 | Le PT Cheng H Ninkovic S | 2012 | Bioorg Med Chem Lett2012，22，15： | 1 |
| 17 | Effect of within-species plant genotype mixing on habitat pref- erence of a polyphagous insect predator显示文摘 | NINKOVIC V AL ABASSI S AHMED E | 2011 | Oecologia2011，166，： | 1 |
| 18 | Protective role of glutathione reductase in paraquat induced neurotoxicity显示文摘 | Djukic M M Jovanovic M D Ninkovic M | | 0，，02： | 1 |
| 19 | Characterization of a digital micro mirror device for use as an optical mask in imaging and spectroscopy显示文摘 | NINKOV Z | 1998 | SPIE1998，3292，： | 1 |
| 20 | Lower Lip reconstruction: introduction of a new procedure using a functioning gracilis muscle free flap 显示文摘 | Ninkovic M Di-Spilimbergo SS Ninkovic M | 2007 | Plast Reconstr Surg2007，119，5： | 1 |
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