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59篇 您的检索式：作者名="Nobuhiro N"

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	题名	作者	年代	出处	被引量
1	Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy.	Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi	2016	World Journal of Gastroenterology2016，22，44：	5
2	Adult cardiac scalpositive cells differentiate into beating cardiom yocytes 显示文摘	Katsuhisa M Toshio N Nobuhiro N	2004	J Biol Chem2004，279，11：	1
3	Nerve-sparing surgery for advanced rectal cancer patienu:special reference to Dukes C patients显示文摘	Saito N Koda K Nobuhiro	1999	World J Surg1999，23，10：	1
4	Winners and Losers in Housing Markets 显示文摘	NOBUHIRO K ALEXANDER M KALIN N	2011	Journal of Money Credit andBanking2011，43，23：	1
5	Development of tissue-engineeredhuman periodontal ligament constructs with intrinsic angiogenicpotential显示文摘	Nobuhiro N Ayumi H Nao O	2009	Cells Tissues Organs2009，190，6：	1
6	Quantitation of aeetazolamide in rat plasma, brain tissue and cerebrospinal fluid by high-performance liquid chromatography显示文摘	NOBUHIRO I KOHJI N HIDENARI H	1998	Journal of Pharmaceutical and Biomedical Analysis1998，17，8：	1
7	Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intra-cellular drug delivery显示文摘	Younsoo B WooDong J Nobuhiro N	2005	The Royal Society of Chemistry2005，1，：	1
8	Mechanisms underlying decreased hepatic triacylglycerol and cholesterol by dietary bitter melon extract in the rat显示文摘	SENANAYAKE G V K NOBUHIRO F SHOKO N	2012	Lipids2012，47，：	1
9	Difference between kidney and liver in decreased manganese superoxide dismutase activity caused by exposure of mice to mercuric chloride显示文摘	Nobuhiro S Yoshito K Jun N	2002	Arch Toxicol2002，76，：	1
10	MARCH-V is a novel mitof us in 2- and Drp1-binding protein able to change mitochondrial morphology显示文摘	Nobuhiro N Yasuo K Masaki T	2006	EMBO Rep2006，7，10：	1
11	Localization analysis of fluorescent-labeled Aeromonas veronii in the intestinal tract of carp using an in vivo imaging system 显示文摘	Aki N Nobuhiro M Hitomi H	2012	Fish Pathology2012，47，1：	1
12	显示文摘	Nobuhiro N	2007	Nature Nanotech2007，2，4：	1
13	Fabrication of a maxillofacial prosthesis using a computer-aided design and manufacturing system显示文摘	Mitsuhiro T Nobuhiro N Koichiro I	2004	J Prosthodont2004，13，：	1
14	Muhifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery显示文摘	Younsoo B WooDong J Nobuhiro N	2005	The Royal Society of Chemistry2005，1，：	1
15	Cavopulmo- nary connect ion after repair of no confluent pulmonary atresia and total anomalous pulmonary venous connection 显示文摘	Miyamoto T Nobuhiro N Kagami M	2003	J Thorac Cardiovasc Surg2003，125，3：	1
16	Induction,purification and possible function of chitinase in cultured carrot cells 显示文摘	FUMIYA K NOBUHIRO T ARASUKE N	1987	Physiological and Molecular Plant Patholog''y1987，31，：	1
17	Bi1/2Na1/2 TiO3 - BaTiO3 - BiFeO3 system 显示文摘	Hajime N Nobuhiro K Nobuhtsa K	1999	Ferroeleetrics1999，229，14：	1
18	The prevalence of inflammation in carotid atherosclerosis analysis with fluorodeoxyglucose-positron emission tomo graphy显示文摘	NOBUHIRO T HISASHI K HIROYUKI N	2007	Eur Heart J2007，28，：	1
19	Nerve-sparing surgery for advanced rectal cancer patients:spectial reference to Dukes C patients显示文摘	Saito N Koda K Nobuhiro	1999	World J Surg1999，23，10：	1
20	Nerve-sparing surgery for advanced rectal cancer patients : spectial reference to Dukes C patients显示文摘	Saito N Koda K Nobuhiro	1999	World J Surg1999，23，10：	1

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