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| 1 | Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders显示文摘Deep brain stimulation(DBS) is emerging as a pow-erful tool for the alleviation of targeted symptoms in treatment-resistant neuropsychiatric disorders. Despite the expanding use of neuropsychiatric DBS, the mecha-nisms responsible for its effects are only starting to be elucidated. Several modalities such as quantitative elec-troencephalography as well a intraoperative recordings have been utilized to attempt to understand the under-pinnings of this new treatment modality, but functional imaging appears to offer several unique advantages. Functional imaging techniques like positron emission tomography, single photon emission computed tomog-raphy and functional magnetic resonance imaging have been used to examine the effects of focal DBS on activ-ity in a distributed neural network. These investigations are critical for advancing the field of invasive neuro-modulation in a safe and effective manner, particularly in terms of defining the neuroanatomical targets and refining the stimulation protocols. The purpose of this review is to summarize the current functional neuroim-aging findings from neuropsychiatric DBS implantation for three disorders: treatment-resistant depression, obsessive-compulsive disorder, and Tourette syndrome. All of the major targets will be discussed(Nucleus ac-cumbens, anterior limb of internal capsule, subcallosal cingulate, Subthalamic nucleus, Centromedial nucleus of the thalamus-Parafasicular complex, frontal pole, and dorsolateral prefrontal cortex). We will also address some apparent inconsistencies within this literature, and suggest potential future directions for this promis-ing area. | Nolan R Williams Joseph J Taylor Kayla Lamb Colleen A Hanlon E Baron Short Mark S George | 2014 | World Journal of Radiology2014，6，10： | 6 |
| 2 | Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study 显示文摘 | RAUCH A NOLAN D MARTIN A | 2006 | Clin Infect Dis2006，43，1： | 1 |
| 3 | Suspension array technology:evolution of the flat-array paradigm显示文摘 | NOLAN LARRY A S | 2002 | Trends in Biotechnology2002，20，1： | 1 |
| 4 | Weight loss reduces C - reactive protein levels in obese postmenopausal women显示文摘 | Tchernof A Nolan A Sites CK | 2002 | Circulation2002，105，5： | 1 |
| 5 | Variability of EGRET Gamma-ray sources 显示文摘 | Nolan P L Tompkins W F Grenier I A | 2003 | Astrophys J2003，597，1： | 1 |
| 6 | Parkinson's disease in the nuclear age of neuroinflammation 显示文摘 | Nolan YM Sullivan AM Toulouse A | 2013 | Trends Mol Med2013，19，3： | 1 |
| 7 | Survival after pulmonary edema due to enterovirus 71 encephalitis显示文摘 | NOLAN N A CRAIG M E LAHRA M M | 2003 | Neurology2003，60，10： | 1 |
| 8 | Quantification of mRNA using real-time RT-PCR 显示文摘 | Nolan T Hands R E Bustin S A | 2006 | Nat Protoc2006，1，3： | 1 |
| 9 | Recommended guidelines for reviewing,reporting,and conducting research on post-resuscitation care:The Utstein style显示文摘 | Langhelle A Nolan J Herlitz J | 2005 | Resuscitation2005，66，： | 1 |
| 10 | Near-surface moisture gradients and in situ permeation tests显示文摘 | Basheer P A M Nolan 1 | 2001 | Construction and Building Materials2001，15，23： | 1 |
| 11 | 2006, Quantification of mRNA using Real-time RT-PCR显示文摘 | Nolan T Hands R E Bustin S A | 2006 | Nature Protocols2006，1，3： | 1 |
| 12 | Inhibited neutrophil apoptosis:proteasome dependent NF-kappaB translocation is required for TRAF1 synthesis显示文摘 | Nolan B Kim R Duffy A | 2000 | Shock2000，14，： | 1 |
| 13 | Measurement of labile Cu in soil using stable isotope dilution and isotope ratio analysis by ICP-MS显示文摘 | Nolan A L Ma Y B Lombi E | 2004 | Analytical and Bioanalytical Chemistry2004，380，： | 1 |
| 14 | Association of polymorphisms of IGF1R and genes in the transforming growth factor-beta/bone morphogenetic protein pathway with bacteremia in sickle cell anemia显示文摘 | Adewoye A H Nolan V G Ma Q | 2006 | Clinical Infectious Diseases2006，43，5： | 1 |
| 15 | Discussions on the use of fine water sprays or mists for fire suppression显示文摘 | A Jones P F Nolan | 1995 | Journal of Loss Prevention in the Process Industries1995，8，1： | 1 |
| 16 | Weight loss reduces C-reactive protein levels in obese postmenopausal women显示文摘 | Tchernof A Nolan A Sites CK | 2002 | Circulation2002，105，5： | 1 |
| 17 | Effect of rosiglitazone on the differential expression of diabetes-associated proteins in pancre- atic islets of C57B1/6 lep/lep mice 显示文摘 | Sanehez JC Converset V Nolan A | 2002 | Mol Cell Proteomies2002，1，7： | 1 |
| 18 | Recurrent aph- thous ulceration and food senskivity显示文摘 | Nolan A Lamey PJ Miligan KA | 1991 | J Oral Pathol Med1991，20，10： | 1 |
| 19 | Confusing Counter intelligence with Security Can Wreck Your Afternoon 显示文摘 | Nolan III J A | 1997 | Competitive Intelligence Review1997，8，3： | 1 |
| 20 | Nitrogen metabolism in therumen显示文摘 | LENG R A NOLAN J V | 1984 | Journal of Dairy Science1984，67，5： | 1 |
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