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| 1 | Synergistic growth inhibitory effects of Phyllanthus emblica and Terminalia bellerica extracts with conventional cytotoxic agents:Doxorubicin and cisplatin against human hepatocellular carcinoma and lung cancer cells显示文摘AIM: To examine the growth inhibitory effects of Phyllanthus emblica (P. emblica) and Terminalia bellerica (T. bellerica) extracts on human hepatocellular carcinoma (HepG2), and lung carcinoma (A549) cells and their synergistic effect with doxorubicin or cisplatin. METHODS: HepG2 and A549 cells were treated with P. emblica and T. bellerica extracts either alone or in combination with doxorubicin or cisplatin and effects on cell growth were determined using the sulforhodamine B (SRB) assay. The isobologram and combination index (CI) method of Chou-Talalay were used to evaluate interactions between plant extracts and drugs. RESULTS: P. emblica and T. bellerica extracts demonstrated growth inhibitory activity, with a certain degree of selectivity against the two cancer cell lines tested. Synergistic effects (CI < 1) for P. emblica /doxorubicin or cisplatin at different dose levels were demonstrated in A549 and HepG2 cells. The T. bellerica/ cisplatin or doxorubicin also showed synergistic effects in A549 and HepG2 cells. In some instances, the combinations resulted in antagonistic effects. The dose reduction level was different and specific to each combination and cell line. CONCLUSION: The growth inhibitory activity of doxorubicin or cisplatin, as a single agent, may be modified by combinations of P. emblica or T. bellerica extracts and be synergistically enhanced in some cases. Depending on the combination ratio, the doses for each drug for a given degree of effect in the combination may be reduced. The mechanisms involved in this interaction between chemotherapeutic drugs and plant extracts remain unclear and should be further evaluated. | Khosit Pinmai Sriharut Chunlaratthanabhorn Chatri Ngamkitidechakul Noppamas Soonthornchareon Chariya Hahnvajanawong | 2008 | World Journal of Gastroenterology2008，14，10： | 19 |
| 2 | Community capacity for sustainable community—based dengue prevention and control:study of a sub—district in Southern Thailand显示文摘Objective:To assess the level of community capacity for dengue prevention and control and to study household environments and larval indices in southern Thailand.Methods:A crosssectional survey was designed for the study,enrolling two communities with higher dengue incidence rate than the standard over the past five years.Data gathering was conducted by the dengue leader group(DLG),including 15 leaders and 15 non-leaders trained by the research team.The dengue community capacity assessment tool(DCCAT) for leaders(115 items.14 domains) and non-leaders(83 items,11 domains).Participants were selected by the DLG based on their communities’ dengue risk.In the low-dengue incidence(LDI) community,32 leaders and 177 non-leaders were selected;while in the high-dengue incidence(HDI) community,31 leaders and 199 non-leaders were chosen.Results:The leaders from the LDI and the HDI communities demonstrated high levels of dengue community-capacity(360.47±58.82,416.22±57.72). Non-leaders in the LDI community demonstrated a moderate level of dengue community capacity competence(205.90±60.76),while the non-leaders in the HDI community had a high level (254.78±50.34).Conclusions:These initial levels of dengue community capacity serves as a baseline for diagnosing each community.For a community that needed to improve its capacity, the DCCAT is essential tool to conduct a pre-post intervention assessment or a serial assessment. A participatory approach is taken to enable local communities to carry out anti-dengue efforts on their own,rather than have intervention by an outsider. | Charuai Suwanbamrung Noppamas Nukan Sarapee Sripon Ratana Somrongthong Phechnoy Singchagchai | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，3： | 3 |
| 3 | Pharmacolinetics of isoflavones, daidzein and genistein, after ingestion of soy beverage compared with soy extract capsules in postmenopausal Thai women 显示文摘 | Ekasin Anupongsanugool Supanimit Teekachunhatean Noppamas Rojanasthien | 2005 | BMC Clin Pharm2005，5，： | 1 |
| 4 | Variation in growth and diterpene lactones among field-cultivated Andrographis paniculata显示文摘 | Sompop Prathanturarug Noppamas Soonthornchareonnon Wongsatit Chuakul Promjit Saralamp | 2007 | Journal of Natural Medicines2007，，2： | 1 |
| 5 | Determination of galacturonic acid from pomelo pectin in term of galactose by HPAEC with fl uorescence detection显示文摘 | Jankana B Noppamas S Amornrut C | 2010 | Carbohydrate Polymers2010，81，： | 1 |
| 6 | Effects of abiotic and biotic elicitors on growth and isoflavonoid accumulation in Pueraria candollei var. candollei and P. candollei var. mirifica cell suspension cultures显示文摘 | Sirintra Korsangruang Noppamas Soonthornchareonnon Yupyn Chintapakorn Promchit Saralamp Sompop Prathanturarug | 2010 | Plant Cell, Tissue and Organ Culture (PCTOC)2010，，3： | 1 |
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