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| 1 | Long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging显示文摘BACKGROUND Prospective study of 200 patients with hepatocellular carcinoma(HCC)that underwent liver transplant(LT)after drug-eluting beads transarterial chemoembolization(DEB-TACE)for downstaging versus bridging.Overall survival and tumor recurrence rates were calculated,eligibility for LT,time on the waiting list and radiological response were compared.After TACE,only patients within Milan Criteria(MC)were transplanted.More patients underwent LT in bridging group.Five-year post-transplant overall survival,recurrence-free survival has no difference between the groups.Complete response was observed more frequently in bridging group.Patients in DS group can achieve posttransplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE.AIM To determine long-term outcomes of patients with HCC that underwent LT after DEB-TACE for downstaging vs bridging.METHODS Prospective cohort study of 200 patients included from April 2011 through June 2014.Bridging group included patients within MC.Downstaging group(out of MC)was divided in 5 subgroups(G1 to G5).Total tumor diameter was≤8 cm for G1,2,3,4(n=42)and was>8 cm for G5(n=22).Downstaging(n=64)and bridging(n=136)populations were not significantly different.Overall survival and tumor recurrence rates were calculated by the Kaplan-Meier method.Additionally,eligibility for LT,time on the waiting list until LT and radiological response were compared.RESULTS After TACE,only patients within MC were transplanted.More patients underwent LT in bridging group 65.9%(P=0.001).Downstaging population presented:higher number of nodules 2.81(P=0.001);larger total tumor diameter 8.09(P=0.001);multifocal HCC 78%(P=0.001);more post-transplantation recurrence 25%(P=0.02).Patients with maximal tumor diameter up to 7.05 cm were more likely to receive LT(P=0.005).Median time on the waiting list was significantly longer in downstaging group 10.6 mo(P=0.028).Five-year posttransplant overall survival was 73.5%in downstaging and 72.3%bridging groups(P=0.31),and recurrence-free survival was 62.1%in downstaging and 74.8%bridging groups(P=0.93).Radiological response:complete response was observed more frequently in bridging group(P=0.004).CONCLUSION Tumors initially exceeding the MC down-staged after DEB-TACE,can achieve post-transplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE. | Breno Boueri Affonso Francisco Leonardo Galastri Joaquim Mauricio da Motta Leal Filho Felipe Nasser Priscila Mina Falsarella Rafael Noronha Cavalcante Marcio Dias de Almeida Guilherme Eduardo Goncalves Felga Leonardo Guedes Moreira Valle Nelson Wolosker | 2019 | World Journal of Gastroenterology2019，25，37： | 21 |
| 2 | Definition of the Portuguese frameworks with international relevance as an input for the European geological heritage characterisation显示文摘 | J. Brilha C. Andrade A. Azeredo F.J.A.S. Barriga M. Cachāo2 H. Couto P.P. Cunha J.A. Crispim P. Dantas L. V. Duarte M. C Freitas H.M. Granja M.H. Henriques P. Henriques L. Lopes J. Madeira J.M.X. Matos F. Noronha J. Pais J. Pifarra M.M. Ramalho J.M.R.S. Relvas A. Ribeiro A. Santos V.F.Santos P. Terrinha | 2005 | Episodes2005，28，3： | 5 |
| 3 | 贝伐单抗治疗湿性年龄相关黄斑变性患者SD-OCT形态学变化(英文)显示文摘目的:研究频域光学相干断层成像(spectral domain optical coherence tomography,SD-OCT)定量和定性检测指标在接受玻璃体腔内注射贝伐单抗的年龄相关性黄斑变性(agerelated macular degeneration,AMD)患者人群中的变化,以评估这些指标是否可以用于预测治疗后视力情况。方法:回顾性分析66眼61例未进行过AMD相关治疗的患者接受至少3mo玻璃体腔内注射贝伐单抗治疗的情况。治疗前后SD-OCT定量检测指标[中央视网膜厚度(central foveal thickness,CFT),外界膜(external limiting membrane,ELM)和椭圆区(ellipsoid zone,EZ)长度]和定性检测指标进行分析和比较。同时,分析这些指标和治疗前后的视力的相关性。结果:平均视力(Log MAR)、CFT、ELM和EZ长度治疗前为0.62±0.41、419.3±110.0μm、378.2±377.2μm和156.4±253.7μm,治疗后为0.53±0.44、325.8±117.9μm、547.1±421.5μm和173.1±207.1μm。治疗前视力和CFT(rs=0.27)、ELM长度(rs=-0.30)及ELM断裂(rs=0.43)有相关性。治疗后视力同样和治疗后ELM长度相关(rs=-0.40)。治疗后视力和治疗前视力(rs=0.66)、ELM长度(rs=-0.35)和ELM断裂(rs=0.46)相关。结论:研究显示:治疗前视力、ELM长度和ELM断裂可以用于预测治疗后视力。 | Manuel Noronha Nuno Moura-Coelho Teresa Gomes Rita Flores Marco Dutra Medeiros | 2017 | 国际眼科杂志2017，17，3： | 3 |
| 4 | Methane Direct Conversion on Mo/ZSM-5 Catalysts Modified by Pd and Ru显示文摘到在甲烷的 dehydroaromatization 使用的 Mo/HZSM-5 催化剂的 Ru 和 Pd 的增加的效果被调查。催化测试和规划温度的氧化结果证明基于 Pd 的催化剂对萘更选择并且承受了强壮的释放。因为 Mo2C 表面的保护的机制, Ru 的存在可能改进了这项活动和稳定性,与在碳质沉积的减少。给词调音:甲烷;Pd;Ru;瞬间;ZSM-5; | Priscila Dias Sily Fabio Bellot Noronha Fabio Barboza Passos | 2006 | Journal of Natural Gas Chemistry2006，15，2： | 2 |
| 5 | Schistosoma mansoni: migration patterns in normal and immunized Swiss Webster mice, by means of autoradiographic analysis显示文摘 | Noronha D Almeida MS | 1987 | Mem Inst Oswaldo Cruz1987，82，4： | 1 |
| 6 | Influence of Processing Parameters on the Texture and iicrostructure of Imitation Cheese显示文摘 | NORONHA E N O'PIORDAN E D O'SULLIVAN M | 2008 | Europe Food R esearch Technology2008，226，： | 1 |
| 7 | WWW-based negotiation support:Design,implementation,and use显示文摘 | KERSTEN G E NORONHA S J | 1999 | Decision Support Systems1999，25，2： | 1 |
| 8 | Primary nonHodgkin's lymphoma of the liver显示文摘 | Noronha V Shaf NQ Obando JA | | 0，，： | 1 |
| 9 | Prolonged remission from eltrombopag in chronic refractory idiopathic thrombocytopenic purpura显示文摘 | Noronha V Philip SD Joshi A | 2012 | Int J Hematol2012，96，3： | 1 |
| 10 | Inducible ni- tric oxide synthase has divergent effects on vascular and metabolic function in obesity 显示文摘 | NORONHA BT LI JM WHEATCROFT SB | 2005 | Diabetes2005，54，4： | 1 |
| 11 | Characterization of Pd-CeO2 interaction on alumina support and hydrogenation of 1,3-butadiene显示文摘 | Montero R D S Noronha F B DIeguez L C | 1995 | Appl Catal A1995，131，1： | 1 |
| 12 | Spatiotemporal Simulation of Urban Growth Patterns Using Agent-based Modeling: The Case of Tehran显示文摘 | Jamal JoKar Arsanjani Marco Helbich Eric de Noronha Vaz | 2013 | Cities2013，，32： | 1 |
| 13 | Immature reticulocytes as an early predictor of engraftment in autologous and allogeneic bone marrow transplantation显示文摘 | Noronha JF De Souza CA Vigorito AC | 2003 | Clin Lab Haematol2003，25，5： | 1 |
| 14 | Recycling of spent process water in the food industry by an integrated process of biological treatment and membrane separation显示文摘 | Blocher C Noronha M Funfroeken F | 2002 | Desalination2002，144，： | 1 |
| 15 | Expression of cytokine and growth factor in human glomerulonephrritides 显示文摘 | WALDHERR R NORONHA I L NIEMIR Z | 1993 | Pediatr Nephrol1993，7，4： | 1 |
| 16 | Amniotic fluidvol-umeassociated with fetai anomalies diagnosis in a refereence center in the biazilian northeast 显示文摘 | NORONHA NC SOUZA AS MORAES OB | 2009 | Rev Bras Ginecol Obstet2009，31，4： | 1 |
| 17 | PDGF and TGF-beta con- tribute to the natural course of human IgA glomerulone- phritis显示文摘 | Niemer Z Stein H Noronha I | 1995 | Kidney Int1995，48，5： | 1 |
| 18 | Spatiotemporal simulation of urban growth patterns using agent-based modeling The case of Tehran显示文摘 | JOKAR ARSANJANI J HELBICH M DE NORONHA VAZ E | 2013 | Cities2013，32，： | 1 |
| 19 | Subduralhae-matoma:a potentially serious consequence of spontaneous in-tracranial hypotension显示文摘 | Noronha RJ Sharrack B Hadjivassiliou M | 2003 | Jneurol Neurosurgpsychiatry2003，74，6： | 1 |
| 20 | WWW, based negotiation support, design, implementation and use显示文摘 | Kersten G E Noronha S J | 1999 | Derision Support Systems1999，，25： | 1 |
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