|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 2 | Laparoscopic approach to Meckel's diverticulum显示文摘AIM: To retrospective review the laparoscopic management of Meckel Diverticulum(MD) in two Italian Pediatric Surgery Centers.METHODS: Between January 2002 and December 2012, 19 trans-umbilical laparoscopic-assisted(TULA) procedures were performed for suspected MD. The children were hospitalized for gastrointestinal bleeding and/or recurrent abdominal pain. Median age at diagnosis was 5.4 years(range 6 mo-15 years). The study included 15 boys and 4 girls. All patients underwent clinical examination, routine laboratory tests, abdominal ultrasound and technetium-99m pertechnetate scan, and patients with bleeding underwent gastrointestinal endoscopy. The abdominal exploration was performed with a 10 mm operative laparoscope. Pneumoperitoneum was establishedbased on the body weight. Systematic overview of the peritoneal cavity allowed the ileum to be grasped with an atraumatic instrument. The complete exploration and surgical treatment of MD were performed extracorporeally, after intestinal exteriorization through the umbilicus. All patients' demographics, main clinical features, diagnostic investigations, operative time, histopathology reports, conversion rate, hospital stay and complications were registered and analyzed.RESULTS: MD was identified in 17 patients, while 1 had an ileal duplication and 1 a jejunal hemangioma. Fifteen patients had painless intestinal bleeding, while 4 had recurrent abdominal pain and exhibited cyst like structures in an ultrasound study. Eleven patients had a positive technetium-99m pertechnetate scan. In the patients with bleeding, gastrointestinal endoscopy did not name the source of hemorrhage. All patients were subjected to a TULA surgical procedure. An intestinal resection/anastomosis was performed in 14 patients, while 4 had a wedge resection of the diverticulum and 1 underwent stapling diverticulectomy. All surgical procedures were performed without conversion to open laparotomy. Mean operative time was 75 min(range 40-115 min). No major surgical complications were recorded. The median hospital stay was 5-7 d(range 4-13 d). All patients are asymptomatic at a median follow up of 4, 5 years(range 10 mo-10 years).CONCLUSION: Trans-umbilical laparoscopic-assisted Meckel's diverticulectomy is safe and effective in the treatment of MD, with excellent results. | Alfonso Papparella Fabiano Nino Carmine Noviello Antonio Marte Pio Parmeggiani Ascanio Martino Giovanni Cobellis | 2014 | World Journal of Gastroenterology2014，20，25： | 7 |
| 3 | A Pilot Study on Prevention of Catheter-related Urinary Tract Infections with Fluoroquinolones显示文摘 | Esposito S Noviello S Leone S | 2006 | J Chemother2006，18，5： | 1 |
| 4 | A pilot study on prevention of catheter-related urinary tract infections with fluoroquinolones显示文摘 | Esposito S Noviello S Leone S | 2006 | J Chemother2006，18，5： | 1 |
| 5 | Short-course therapy with cefaclor for treatment of streptococcal pharyngotonsillitis显示文摘 | ESPOSITO S NOVIELLO S IANNIELLO F | 2001 | Int J Antimicrob Agents2001，18，4： | 1 |
| 6 | A pilot study on preven- tion of catheter-related urinary tract infections with fluoro- quinolones 显示文摘 | Esposito S Noviello S Leone S | 2010 | J Chemother2010，18，5： | 1 |
| 7 | Cholelithiasis after Bill roth 1I gastric resetion 显示文摘 | Lomsso D Miseiagna G Noviello MR | 1988 | Surgery1988，103，5： | 1 |
| 8 | Loss of heterozygosity on the long arm of chromosome 6 in breast cancer:possibly four regions of deletion显示文摘 | Noviello C Courjal F Theillet C | 1996 | Clin Cancer Res1996，2，9： | 1 |
| 9 | In vitro activity of LY333328 (oritavancin) against gram-positive aerobic cocci and synergy with ciprofloxacin against enterococci 显示文摘 | Noviello S Ianniello F Esposito S | 2001 | J Antimicrob Chemother2001，48，： | 1 |
| 10 | In vitro activity of LY 333328 (oritavancin) against Gram-positive aerobic cocci and synergy with ciprofloxacin against enterococci显示文摘 | Noviello S Ianniello F Esposito S | 2001 | J Antimicrob Chemother2001，48，2： | 1 |
| 11 | Prolonged ingestion of ovalbumin diet by Ova sensitized mice suppresses mBSA-induced arthritis显示文摘 | Maria de Lourdes Meirelles Noviello Nathália Vieira Batista Luana Pereira Antunes Dourado Rafaela Vaz Sousa Pereira André Gustavo Oliveira Gustavo Batista Menezes Denise Carmona Cara | 2013 | Cellular Immunology2013，，： | 1 |
| 12 | Predicting the Clinical Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: The Long and Winding Road toward Validated Immune Biomarkers显示文摘 | Forcina A Noviello M Carbone MR | 2013 | Front Immunol2013，4，： | 1 |
| 13 | Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection 显示文摘 | McHutchison JG Lawitz FJ Shiffman ML Muir AJ Galler GW McCone J Nyberg LM Lee WM Ghalib RH Schiff ER Galati JS Bacon BR Davis MN Mukhopadhyay P Koury K Noviello S Pedicone LD Brass CA Albrecht JK Sulkowski MS IDEAL Study Team | 2009 | N Engl J Med2009，361，6： | 1 |
| 14 | Monte Carlo techniques to analyse the electrical mismatch losses in large-scale photovoltaic generators显示文摘 | F. Iannone G. Noviello A. Sarno | 1997 | Solar Energy1997，，2： | 1 |
| 15 | Staged laparo- scopic-assisted endorectal pull-through for long segment Hir- schprung' s disease and total colonic aganglionosis 显示文摘 | CobeUis G Noviello C Cruccetti A | 2011 | Minerva Pediatr2011，63，3： | 1 |
| 16 | A pilot study on prevention of catheter-related urinary tract infections with fluoroquinolones显示文摘 | Esposito S Noviello S Leone S | 2006 | J Chemother2006，18，5： | 1 |
| 17 | A pilot study on prevention of catheter-related urinary tract infections with fluoroquinolones显示文摘 | Esposito S Noviello S Leone S | 2006 | J Chemother2006，18，5： | 1 |
| 18 | Laboratory-acquired bru- cellosis显示文摘 | Noviello S Gallo R Kelly M | 2004 | Emerg Infect Dis2004，10，10： | 1 |
| 19 | A pilot study on prevention of catheter - related urinary tract infections with fluoroquinolones 显示文摘 | Esposito S Noviello S Leone S | 2006 | J Chemother2006，18，5： | 1 |
| 20 | A pilot study on prevention of catheter-related urinary tract infections with fluoroquinolones显示文摘 | Esposito S Noviello S Leone S | 2006 | J Chemother2006，18，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员