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6篇 您的检索式：作者名="Nuno Machado"

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		题名	作者	年代	出处	被引量
	1	Psychotropic drugs and liver disease:A critical review of pharmacokinetics and liver toxicity显示文摘The liver is the organ by which the majority of sub-stances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs. This fact is particularly true in drugs with extensive first--pass metabolism, highly protein bound drugs and drugs depending on phase I hepatic metabolic reactions. Psychopharmacological agents are also associated with a risk of hepatotoxicity. The evidence is insufficient for definite conclusions regarding the prevalence and severity of psychiatric drug-induced liver injury. High-risk psychotropics are not advised when there is pre-existing liver disease, and after starting a psychotropic agent in a patient with hepatic impairment, frequent liver function/lesion monitoring is advised. The authors carefully review the pharmacokinetic disturbances induced by end-stage liver disease and the potential of psychopharmacological agents for liver toxicity.	Diogo Telles-Correia António Barbosa Helena Cortez-Pinto Carlos Campos Nuno B F Rocha Sérgio Machado	2017	World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1：	3
	2	Mitochondrial Involvement in Cardiac Apoptosis During Ischemia and Reperfusion: Can We Close the Box?显示文摘	Nuno G. Machado Marco G. Alves Rui A. Carvalho Paulo J. Oliveira	2009	Cardiovascular Toxicology2009，，4：	1
	3	Influence of graphite nodules geometrical features on fatigue life of high-strength nodular cast iron 显示文摘	Nuno Costa Nuno Machado Filipe Samuel Silva	2008	Joumal of Materials Engineering and Performance2008，17，3：	1
	4	Develop-ment changes of anthocyanins inVitis viniferagrapesgrown in the Douro Valley and concentration in respectivewines显示文摘	Nuno Mateus JoséM Machado victor de Fretas	2002	Journal of the Science of Food and Agriculture2002，82，：	1
	5	Influence of graphite nodules geometrical features on fatigue life of high-strength nodular cast iron显示文摘	Nuno Costa Nuno Machado Filipe Samuel Silva	2008	JMEPEG2008，17，：	1
	6	Hybrid adaptive control of a dragonfly model 显示文摘	COUCEIRO Micael S FERREIRA Nuno M F MACHADO J A Tenreiro	2012	Communications in Nonlinear Science and Numerical Simulation2012，17，2：	1

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