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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 3 | Modeling material failure in concrete structures under cyelie aetions显示文摘 | Faria R Oliver J Cervera M | 2004 | Journal of Structural Engineering2004，130，12： | 1 |
| 4 | Impact of sodium and uhrafihration profiling on hemodialysis- related symptoms 显示文摘 | Oliver M J Edwards LJ Churchill DN | 2001 | J Am Soc Nephrol2001，12，1： | 1 |
| 5 | On the Measurement of Stress-strain Curves by Spherical Indentation显示文摘 | E G Herbert G M Pharr W C Oliver B N Lucas J L Hay | 2001 | Thin Solid Films2001，，： | 1 |
| 6 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 7 | Extrahepatic metastases of hepatocellular carcinoma 显示文摘 | Katyal S Oliver J H Peterson M S | 2000 | Radiology2000，216，3： | 1 |
| 8 | Selective oxidation and ammoxidation of propane on a Mo-V-Te-Nb-O mixed metal oxide catalyst: A comparative study 显示文摘 | OLIVER J M LOPEZ NIETO J M | 2004 | Catalysis Today2004，96，4： | 1 |
| 9 | Bovine lactofemn supplementation supports immune and antioxidant status in healthy human males显示文摘 | MULDER A M CONNELLAN P A OLIVER C J | 2008 | Nutrition Research2008，28，： | 1 |
| 10 | Smooth muscle cells orchestrate the endothelial cell response to flow and injury 显示文摘 | Balcells M Martorell J Olive C | 2010 | Circulation2010，121，20： | 1 |
| 11 | Measurement of flour color in color space parameters 显示文摘 | Oliver J R Blakeney A B Allen H M | 1992 | Cereal Chemistry1992，69，5： | 1 |
| 12 | A geostatistical analysis of the spatial variation of soil mineral nitrogen and potentially available nitrogen within an arable field显示文摘 | Baxter S J Oliver M A Gaunt J | 2003 | Precision Agriculture2003，，4： | 1 |
| 13 | Arteriovenous fistula outcomes in the era of the elderly dialysis population 显示文摘 | Lok C Oliver M Su J | 2005 | Kidney Int2005，67，6： | 1 |
| 14 | The legitimacy of strategic alliances: An institutional perspective显示文摘 | Dacin M T Oliver C Roy J P | 2007 | Strategic Management Journal2007，28，2： | 1 |
| 15 | The impact of technology invest- ments on a firm's production efficiency, product quality, and pro- ductivity 显示文摘 | THATCHER M E OLIVER J R | 2001 | Journal of Management Information Systems2001，18，2： | 1 |
| 16 | Epidermal growth factor receptor inhibition by tyrphostin 51 induces apoptosis in luteinized granulosa cells 显示文摘 | Khan S M Oliver R H Yeh J | 2005 | J Clin Endocrinol Metab2005，90，1： | 1 |
| 17 | Cloning,sequence comparison and in vivo expression of the gene encoding rat P-selectin显示文摘 | AUCHAMPACH J A OLIVER M G ANDERSON D C | 1994 | Gene1994，145，： | 1 |
| 18 | Mix and match: how climate selectsphytoplankton 显示文摘 | Falkowski P G Oliver M J | 2007 | Nat Rev Micro2007，5，10： | 1 |
| 19 | Virtual reality for assembly methods prototyping: A review 显示文摘 | Seth A Vance J M Oliver J H | 2011 | Virtual Reality2011，15，1： | 1 |
| 20 | Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension显示文摘 | JOHN S W KREGE J H OLIVER P M | 1995 | Science1995，267，5198： | 1 |
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