|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Smoking increases the risk of extraintestinal manifestations in Crohn's disease显示文摘AIM:To demonstrate a high prevalence of extraintestinal manifestations(EIMs)in a prospective populationbased cohort of inflammatory bowel disease(IBD)patients at first diagnosis as well as during the early course of the disease.METHODS:EIMs are common in patients with IBD.Data on the frequency of EIMs have mostly been assessed in patients from tertiary centers;however,data about the prevalence of EIMs at first diagnosis as well as factors influencing their incidence during the early course of disease from prospective population-based cohorts are scarce.We present data of patients of our population-based'Oberpfalz cohort'(Bavaria,Germany)from first diagnosis(up to 3 mo after first diagnosis)as well as during the early course of the disease.Possible risk factors were assessed by calculating the relative risk(RR)as well as using logistic regression analysis.RESULTS:In total,data of 257 newly diagnosed patients with IBD were evaluated[161 Crohn’s disease(CD),96 ulcerative colitis(UC)].Median duration of follow-up was 50 mo after first diagnosis.In 63.4%of all patients(n=163),an EIM was diagnosed at any point during the observation period.At first diagnosis,patients with CD had a significantly increased risk of an EIM[n=69(42.9%)]compared with UC patients[n=21(21.9%);P<0.001;RR=1.96;95%CI:1.30-2.98].Active smoking increased the risk of CD patients developing an EIM during the early course of the disease,but notably not of UC patients(P=0.046;RR=1.96;95%CI:1.01-3.79).In addition,using logistic regression analysis,the need for IBD-related surgery and a young age at first diagnosis were identified as risk factors for the development of an EIM in CD patients.No association with EIMs was found for the factors sex,localization of the disease and positive family history of IBD.In contrast,no key factors which increased the risk of development of an EIM could be identified in UC patients.CONCLUSION:We found a high prevalence of EIM in this cohort at first diagnosis and during the early course of the disease.In patients with CD,smoking,need for surgery and younger age at first diagnosis were risk factors for the development of an EIM. | Claudia Ott Angela Takses Florian Obermeier Elisabeth Schnoy Martina Müller | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 2 | Does early improve- ment triggered by antidepressants predict response/remission? Analysis of data from a naturalistic study on a large sample of inpatients with major depression显示文摘 | Henkel V Seemu Iler F Obermeier M | 2009 | Affect Disord2009，115，3： | 1 |
| 3 | Does early improvement triggered by antidepressants predict response/ remission? Analysis of data from a naturalistic study on a large sample of inpatients with major depression显示文摘 | Henkel V Seemuller F Obermeier M | 2009 | J Affect Disord2009，115，3： | 1 |
| 4 | Circulating levels of chemerin and adiponectin are higher in ulcerative colitis and chemerin is elevated in Crohn's disease显示文摘 | Weigert J Obermeier F Neumeier M | 2010 | Inflamm Bowel Dis2010，16，4： | 1 |
| 5 | Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibitian in vivo 显示文摘 | Menzel K Hausmann M Obermeier F | 2006 | Clin Exp Immunol2006，146，1： | 1 |
| 6 | Is the PANSS used correctly a systematic review显示文摘 | Obermeier M Schennach-Wolff R Meyer S | 2011 | BMC Psychiatry2011，11，7： | 1 |
| 7 | Response and remission criteria in major depression-a validation of current practice显示文摘 | Riedel M Mller HJ Obermeier M | 2010 | J Psychiatr Res2010，44，： | 1 |
| 8 | Development, maintenance and disruption of the blood-brainbarrier显示文摘 | Birgit Obermeier Richard Daneman Richard M Ransohoff | 2013 | Nat Med2013，19，12： | 1 |
| 9 | Role of TLR9 in hepatic stellate cells and experimental liver fibrosis 显示文摘 | Ggbele E M/ihlbauer M Dorn C Weiss TS Froh M Schnabl B Wiest R Sch61merich J Obermeier F Hellerbrand C | 2008 | Biochem Biophys Res Commun2008，376，2： | 1 |
| 10 | Does early improve- ment triggered by antidepressants predict response/remission? A- nalysis of data from a naturalistic study on a large sample of inpa- tients with major depression 显示文摘 | Henkel V Seemiiller F Obermeier M | 2009 | Affect Disord2009，115，3： | 1 |
| 11 | Quality of life and subjective well-being in schizophrenia and schizophrenia spectrum disorders: valid predictors of symp- tomatic response and remission? 显示文摘 | Schennach-Wolff R Jager M Obermeier M | 2010 | World J Biol Psychia- try2010，11，5： | 1 |
| 12 | Flavonoid-C-glycosides from Triticum aestivuml L显示文摘 | Wagner H Obermeier G Chari V M | 1980 | J Nat Prod1980，43，： | 1 |
| 13 | In vitro characterization and pharmacokinetics of dapagliflozin (BMS- 512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humans显示文摘 | Obermeier M Yao M Khanna A | 2010 | Drug Metab Dispos2010，38，3： | 1 |
| 14 | In vitro characterizationand pharmacokinetics of dapagliflozin, a potent sodium-glucose cotransporter type II inhibitors,in animals and humans显示文摘 | Obermeier M Yao M Khanna A | 2010 | Drug Metab Dispos2010，38，3： | 1 |
| 15 | CD22ligand-binding and signaling domains reciprocally regulate B-cell Ca2+signaling显示文摘 | Muller J Obermeier I Wohner M | 2013 | Proc Natl Acad Sci U S A2013，110，12： | 1 |
| 16 | Predicting care giver burden in first admission psychiatric patients显示文摘 | MOller-Leimkiihler A M Obermeier M | 2008 | Eur Arch Psychiatry Clin Neurosci2008，258，40： | 1 |
| 17 | Does early improvement triggered by antidepressants predict response/remis- sion? Analysis of date from a naturalistic study on a large sample of inpatients with major depression 显示文摘 | HENKEL V SEEMULLER F OBERMEIER M | 2009 | J Affect Disord2009，115，3： | 1 |
| 18 | Does early improvement in major depression protect against treatment emergent suicidal ideation? 显示文摘 | Seemuller F Schennach-Wolff R Obermeier M | 2010 | J Affect Disord2010，124，12： | 1 |
| 19 | Cell-cell contacts prevent anoikis in primary human colonic ep ithelial cells显示文摘 | Hofmann C Obermeier F Artinger M | 2007 | Gastroenterology2007，132，2： | 1 |
| 20 | Does early improvement triggered by antidepressants predict response/ remission? Analysis of data from a naturalistic study on a large sample of inpatients with major depression显示文摘 | Henkel V Seemuller F Obermeier M | 2009 | J Affect Disord2009，115，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员