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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | What are the current and potential future roles for endoscopic ultrasound in the treatment of pancreatic cancer?显示文摘Pancreatic adenocarcinoma is the fourth leading cause of cancer-related death in the United States. Due to the aggressive tumor biology and late manifestations of the disease, long-term survival is extremely uncommon and the current 5-year survival rate is 7%. Over the last two decades, endoscopic ultrasound(EUS) has evolved from a diagnostic modality to a minimally invasive therapeutic alternative to radiologic procedures and surgery for pancreatic diseases. EUSguided celiac plexus intervention is a useful adjunct to conventional analgesia for patients with pancreatic cancer. EUS-guided biliary drainage has emerged as a viable option in patients who have failed endoscopic retrograde cholangiopancreatography. Recently, the use of lumen-apposing metal stent to create gastrojejunal anastomosis under EUS and fluoroscopic guidance in patients with malignant gastric outlet obstruction has been reported. On the other hand, anti-tumor therapies delivered by EUS, such as the injection of anti-tumor agents, brachytherapy and ablations are still in the experimental stage without clear survival benefit. In this article, we provide updates on well-established EUS-guided interventions as well as novel techniques relevant to pancreatic cancer. | Stephen Y Oh Shayan Irani Richard A Kozarek | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，7： | 5 |
| 3 | 高性能粉末冶金连杆在V6发动机中的应用显示文摘今天,减轻连杆重量对满足现代内燃机的各项要求是至关重要的。为了降低产品成本、改善NVH特性和提高轴瓦的可靠性,现代汽车公司(HMC)已采用粉末冶金锻造连杆取代传统的热锻连杆。通过提高质量和降低成本的优化设计,开发了轻型连杆。值得注意的是,粉末冶金锻造连杆的质量比传统的热锻连杆的质量小17.7%,而且,连杆大头质量比传统型连杆大头的质量小22.5%。采用轻型连杆可减小曲轴系的质量,从而也减小了主要运动件的质量。由于减小了质量,轴瓦可靠性和NVH特性均可提高。HMC在一台新型V6发动机上进行了疲劳、刚度和装机耐久性等对比试验。 | Paek S Y Ryou H S Oh J S 沈永生 | 1999 | 国外内燃机1999，31，5： | 2 |
| 4 | GAMMA TITANIUM ALUMINIDE ALLOY TECHNOLOGY:STATUS AND FUTURE显示文摘Gam matitanium aluminide ( γ TiAl) alloys are emerging as a revolutionary engineeringmaterialsfor hightemperaturestructuralapplications. Onthebasisoftheinformation avail ablein the public domain, this paper discussesthe historical background,status and future prospect of gam maalloytechnologyintheareasofalloy development/ design,processdevelop ment, and applications. | Y W.Kim UES,Inc.,OH, USA | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，4： | 2 |
| 5 | Network - based approach to on -line cursive script recognition 显示文摘 | SIN B K HA J Y OH S C | 1999 | IEEE Transaction on System Man and Cybernetics-Part B:Cybernetics1999，29，2： | 2 |
| 6 | The insulinlike growth factor-binding protein (IGFBP) super family显示文摘 | HWA V OH Y ROSENFELD R G | 1999 | Endocrine Rev1999，20，： | 1 |
| 7 | Glomerular score as a prognosticator in Ig, A nephropathy: its usefulness and limitation 显示文摘 | Katafuchi R Kiyoshi Y Oh Y | 1998 | Clin Nephrol1998，49，： | 1 |
| 8 | Characteristics of nitrile--butadiene rubber layered silicate nanocomposites with silane coupling agent 显示文摘 | Kim J T Lee D Y Oh T S | 2003 | J Appl Polym Sci2003，89，10： | 1 |
| 9 | Mechanical Behavior of Carbon Steels in the Temperature Range of Mushy Zone显示文摘 | Seol D J Won Y M Oh K H | 2000 | ISIJ International2000，40，4： | 1 |
| 10 | A new class of SN2 reactions catalyzed by protic solvents: facile fluorination for isotopic labeling of diagnostic molecules 显示文摘 | Kim D W Ahn D S Oh Y H | 2006 | J Am Chem Soc2006，128，16： | 1 |
| 11 | Microstruetural characterization of Al2O3-Ni composites prepared by electroless deposition 显示文摘 | OH I H LEE J Y HAN J K | 2005 | Surf Coat Technol2005，192，： | 1 |
| 12 | Antiherpetic activities of acidic protein bound polysaccharide isolated from Ganoderma lucidumalone and in combinations with mterferons 显示文摘 | Kim Y S Eo S K Oh K W etal | 2000 | J Ethnopharmacol2000，72，3： | 1 |
| 13 | Si-carbon core-shell composite anode in lithium secondary batteries 显示文摘 | JUNG Y S LEE K T OH SEUN M | 2007 | Electrochimica Acta2007，52，： | 1 |
| 14 | Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy 显示文摘 | Li Y Yu J | 2004 | Nature2004，429，6992： | 1 |
| 15 | A cytochrome P450 gene is differentially expressed in compa-ible and incompatible interactions between pepper(Capsicum annuum)and the anthracnose fungus,Colletotrichum gloeosp-orioides显示文摘 | Ko M K Kim Y S | 1999 | Mol Plant-microbe Interaction1999，12，： | 1 |
| 16 | In situ single-molecule detection of antibody-antigen binding by tapping-mode atomic force microscopy显示文摘 | LI L Y CHEN S F OH S J | 2002 | Anal Chem2002，74，23： | 1 |
| 17 | Adriamycin-induced nephropathy as a model of chronic progressive glomerular disease显示文摘 | Okuda S Oh Y Tsuruda H Onoyama K Fujimi S Fujishima M | 1986 | Kidney Int1986，29，2： | 1 |
| 18 | End-to-end QoS guaranteed service in WLAN and3GPP interworking network显示文摘 | OH S M KIM J HWANG Y | 2006 | Lect Notes Comput Sci2006，，： | 1 |
| 19 | Surface plasmon resonance immunosensor for the detection of Salmonella typhimurium 显示文摘 | OH B K KIM Y K PARK K W | 2004 | Biosens Bioelectron2004，19，11： | 1 |
| 20 | Spatial distribution of nerve sprouting after myocardial infarction in mice显示文摘 | Oh Y S Jong A Y Kim D T | 2006 | Heart Rhythm2006，3，6： | 1 |
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