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| 1 | High adiponectin levels fail to protect against the risk of hypertension and,in women,against coronary disease:involvement in autoimmunity?显示文摘AIM:To investigate whether serum adiponectin protects against cardiometabolic risk in a population sample with prevailing metabolic syndrome.METHODS:Middle-aged adults representative of a general population with baseline circulating adiponectin measurements(n=1224)were analyzed prospectively at a mean of 3.8 years’follow-up,using continuous values or sex-specific tertiles.Total adiponectin was assayed by an ELISA kit.Type-2 diabetes was identified by criteria of the American Diabetes Association.Hypertension was defined as a blood pressure≥140 mmHg and/or≥90 mmHg and/or use of antihypertensive medication.Outcomes were predicted using Cox proportional hazards regression analysis in models that were controlled for potential confounders.RESULTS:In models of multiple linear regression,sex hormone-binding globulin,fasting insulin(inverse)and,in men,age were significant independent covariates of serum adiponectin which further tended in women to be positively associated with serum creatinine.Cox regression analyses for incident coronary heart disease(CHD),adjusted for sex,age,non-HDL cholesterol,waist circumference and C-reactive protein,revealed significant inverse association with adiponectin tertiles in men but not women(HR=0.66;95%CI:0.32-1.38 for highest tertile).Cox regression for type-2 diabetes in a similar model(wherein glucose replaced non-HDL cholesterol),adiponectin tertiles appeared to protect in each gender.HR for incident hypertension roughly displayed unity in each of the adiponectin tertiles(P-trend=0.67).CONCLUSION:High adiponectin levels failed to protect against the development of hypertension and,in women,against CHD,presumably paralleling impairment in renal function as well.Involvement of adiponectin in autoimmune complex with loss of antioxidative-antiatherogenic properties may be underlying. | Altan Onat Mesut Aydln Günay Can Bayram Kroglu Ahmet Karagz Servet Altay | 2013 | World Journal of Diabetes2013，4，5： | 3 |
| 2 | Determinants and definition of abdominal obesity as related to risk of diabetes, metabolic syndrome and coronary disease in Turkish men: A prospective cohort study显示文摘 | Altan Onat Hüseyin Uyarel Gülay Hergen? Ahmet Karabulut Sinan Albayrak Günay Can | 2006 | Atherosclerosis2006，，1： | 2 |
| 3 | Serum uric acid is a determinant of metabolic syndrome in a population-based study 显示文摘 | Onat A Uyarel H Hergenc G | 2006 | AM J Hypertens2006，19，10： | 1 |
| 4 | An RNA vaccine based on recombinant Semliki Forest virus particles expressing the Cu-Zn superoxide dismutase protein of Brucella abortus induces protective immunity in Balb/c mice显示文摘 | Onate A A Donoso G Moraga C G | 2005 | Infect Immun2005，73，6： | 1 |
| 5 | Elevated serum uric acid in nondiabetic people mark pro-inflammatory state and HDL dysfunction and independently predicts coronary disease显示文摘 | Altan Onat Günay Can Ender ?rnek Servet Altay Murat Yüksel Evin Ademo?lu | 2013 | Clinical Rheumatology2013，，： | 1 |
| 6 | Serumγ-Glutamyltransferase:Independent Predictor of Risk of Diabetes,Hypertension,Metabolic syndrome,and Coronary Disease显示文摘 | Onat A Can G Ornek E | 2011 | Obesity(SilverSpring)2011，，： | 1 |
| 7 | Determinants and defi- nition of abdominal obesity as related to risk of diabetes, metabolic syndrome and coronary disease in Turkish men: a prospective cohort study显示文摘 | Onat A Uyarel H Hergenc G | 2007 | Atherosclerosis2007，191，1： | 1 |
| 8 | Neck circumference as a measure of central obesity:associations with metabolic syndrome and obstructive sleep apnea syndrome beyond waist circumference 显示文摘 | Onat A Hergenc G Yuksel H | 2009 | Clin Nutr2009，28，1： | 1 |
| 9 | A Simple Method for Automatic update of Finite Element Meshes显示文摘 | Chiandussi G Bugeda G Onate E | 2000 | Communication in Numerical Methods in Enginerring2000，16，1： | 1 |
| 10 | Neck circumference as a measure of central obesity: associations with metabolic syndrome and obstructive sleep apnea syndrome beyond waist circumference 显示文摘 | Onat A Hergen G Yiiksel H | 2009 | Clin Nutr2009，28，1： | 1 |
| 11 | Neoadjuvant chemotherapy with P- ELF followed by radical resection in patients with initially unresectable gastric adenocarcinoma显示文摘 | Gallardo Rincon D Onate Ocana LF Calderillo Ruiz G | 2000 | Ann Surg Oncol2000，7，1： | 1 |
| 12 | 'Atherogenic index of plasma' (log10 triglyceride/high-density lipoprotein-cholesterol) predicts high blood pres- sure, diabetes, and vascular events显示文摘 | Onat A Can G Kaya H | 2010 | J Clin Lipidol2010，4，2： | 1 |
| 13 | Viruses in community-acquired pneumonia in children aged less than 3 years old: high rate of viral coinfecfion 显示文摘 | Cilla G Onate E Perez-Yarza EG Montes M Vicente D Perez- Trallero E | 2008 | J Med V2008，80，10： | 1 |
| 14 | Effects of infertility on gender differences in marital relationship and quality of life : A case - control study of Turkish cou- ples 显示文摘 | Onat G Beji KN | 2012 | Eur J Obstet Gynecol Reprod Biol2012，165，2： | 1 |
| 15 | Serum uric acid is a determinant of metabolic syndrome in a population-based study 显示文摘 | Onat A Uyarel H Hergenc G | 2006 | Am J Hyper-tens2006，19，10： | 1 |
| 16 | Serum g-glutamyltransferase:Independent predictor of risk of diabetes,hypertension,metabolic syndrome,and coronary disease显示文摘 | Onat A Can G Ornek E | 2012 | Obesity (Silver Spring)2012，20，4： | 1 |
| 17 | A simple method for automatic update of finite element meshes 显示文摘 | CHIANDUSSI G BUC-EDA G ONATE E | 2000 | Comnmn Nume Meth Engng2000，16，1： | 1 |
| 18 | Serum uric acid is a de-terminant of metabolic syndrome in a population based study显示文摘 | Onat A Uyarel H Hergenc G | 2006 | AM J Hypertens2006，19，10： | 1 |
| 19 | Neck circumference as a measure of central obesity: associations with metabolic syndreme and obstructive sleep apnea syndrome beyond waist circumference 显示文摘 | Onat A Hergenc G Ytiksel H | 2009 | Clin Nutr2009，28，1： | 1 |
| 20 | Predictive value of serum apolipoprotein B/ LDL- cholesterol ratio in cardiometabolic risk:population- based cohort study显示文摘 | Onat A Can G Cicek G | 2010 | Clin Bio ehem2010，43，18： | 1 |
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