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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Asso-ciation analyses of single nucleotide polymorphisms in the LEP and SCD1 genes on the fatty acid profile of muscle fat in Simmental bulls显示文摘 | ORRU L CIFUNI G F PIASENTIER E | 2011 | Meat Sci2011，87，： | 1 |
| 3 | Effect of deamidation on folding of ribonuclease A显示文摘 | ORRU S VITAGLIANO L ESPOSITO L et ol | 2000 | Protein Science2000，9，： | 1 |
| 4 | Characterization of a SNPs panel for meat traceability in six cattle breeds显示文摘 | Orru L Gatillio G Napolitano F | 2009 | Food Control2009，，20： | 1 |
| 5 | Detection and quantitation of hepatitis E virus in human faeces by real-time quantitative PCR 显示文摘 | Orru G Masia G Romano L | 2004 | Virol Meth2004，118，2： | 1 |
| 6 | Exploring polymorphisms and effects on milk traits of the DGAT1, SCD1 and GHR genes in four cattle breeds 显示文摘 | Signorelli F Orru L Napolitano F | 2009 | Livestock Sei2009，125，1： | 1 |
| 7 | Association analyses of single nucleotide polymorphisms in the LEP and SCD1 genes on the fatty acid profile of muscle fat in Simmental bulls 显示文摘 | Orru L Cifuni G F Piasentier E | 2011 | Meat Sci2011，87，： | 1 |
| 8 | Characterization of a SNPs panel for meat traceability in six cattle breeds 显示文摘 | Orru L Catillo G Napolitano F | 2009 | Food Control2009，20，： | 1 |
| 9 | Exploring polymor- phisms and effects on milk traits of the DGAT1, SCD1 and GHR genes in four cattlebreeds显示文摘 | Signorelli F Orru L Napolitano F | 2009 | Livest Sci2009，125，1： | 1 |
| 10 | Single nucleo- tide polymorphism detection in promoterI of the ace-tyl-CoA carboxylase-a gene in sheep 显示文摘 | Moioli B Napolitano F Orru L | 2005 | Journal of Animal Breeding and Genetics2005，59，1： | 1 |
| 11 | Single nucleotide polymorphism detection in promoterⅢ of the acetyl-CoA carboxylase-a gene in sheep显示文摘 | Mololi B Napolitano F Orru L | 2005 | Journal of Animal Breed- ing and Genetics2005，122，6： | 1 |
| 12 | A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells显示文摘 | Rucci N DiGiacinto C Orru L | 2005 | J Cell Sci2005，118，15： | 1 |
| 13 | Complications of endovascular treatment of cerebral aneurysms 显示文摘 | Orru E Roccatagliata L Cester G | 2013 | Eur J Radiol2013，82，10： | 1 |
| 14 | Expression of ATP7B in normal human liver显示文摘 | Fanni D Pilloni L Orru S | 2005 | Eur J Histochem2005，49，4： | 1 |
| 15 | Leaching potential of carbamates and their metabolites and comparison with triazines 显示文摘 | FAVA L ORRU MA SCARDALA S | 2007 | Mieroehemical Journal2007，86，： | 1 |
| 16 | Rapid detection and quantitation of bluetongue virus(BTV) using a molecular beacon fluorescent probe assay显示文摘 | Orru G Ferrando M L Meloni M | 2006 | J Virol Methods2006，137，： | 1 |
| 17 | Ex- ploring polymorphisms and effects on milk traits of the DGAT1, SCD1 and GHR genes in four cattle breeds显示文摘 | Signorelli F Orru L Napolitano F Matteis G D | 2009 | LLivestock Science2009，125，： | 1 |
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