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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Lunar laser ranging:a c ontinuing legacy of the Apollo program显示文摘 | P L Bender J E Faller | 1994 | Science1994，265，： | 1 |
| 3 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic: suboxic diagenesis 显示文摘 | Froelieh P N Klinkhammer G P Bender M L Luedtke N A Heath G R Cullen D Dauphin P Hammond D Hartman B | 1979 | Geoehim Cosmoehim Acta1979，43，7： | 1 |
| 4 | A rechargeable room-temperature sodium superoxide (NaOz) battery显示文摘 | Hartmann P Bender C L Vracar M | 2013 | Nature Materials2013，12，3： | 1 |
| 5 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic:Suboxic diagenesis显示文摘 | Froelich P N Klinkhammer G P Bender M L | 1979 | Geochimica et Cosmochimica Acta1979，43，： | 1 |
| 6 | The distribution of manganese in the Pacific Ocean显示文摘 | Klinkhammer G P Bender M L | 1980 | Earth Planet Sci Lett1980，46，： | 1 |
| 7 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic: Suboxic diagenesis 显示文摘 | Froelieh P N Klinkhammer G P Bender M L Luedtke N A Heath G R Cullen D Dauphin P Hammond D Hartman B Maynard V | 1979 | Geochim Cosmochim Acta1979，43，7： | 1 |
| 8 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic: suboxic diagenesis 显示文摘 | FROELICH P N KLINRHAMMER G P BENDER M L | 1979 | Geochim Cosmochim Acta1979，43，6： | 1 |
| 9 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic:suboxic diagenesis 显示文摘 | Froelich P N Klinkhammer G P Bender M L | 1979 | Geochimica et Cosmochimica Acta1979，43，： | 1 |
| 10 | A comprehensive study on the cell chemistry of the sodium superoxide (NaOz) battery显示文摘 | Hartmann P Bender C L Sann J | 2013 | Physical Chemistry Chemical Physics2013，15，11： | 1 |
| 11 | Can test statistics in covari-ance structure analysis be trusted? 显示文摘 | Hu L T Bender P M Kano Y | 1992 | Psychologically Bulle-tin1992，，112： | 1 |
| 12 | Trace metal distribu- tions in the Hodsoa RNer estuary显示文摘 | Klinkhammer G P Bender M L | 1981 | Estuarine Coastal and Shelf Science1981，2，： | 1 |
| 13 | The marine phosphorus cycling 显示文摘 | Froelich P N Bender M L Luedtke N A | 1982 | Am J Sci1982，282，： | 1 |
| 14 | The Morphology of High Volume Fraction Solid-Liquid Mixtures: An Application of Microstructural Tomography 显示文摘 | Wolfsdorf T L Bender W H Voorhees P W | 1997 | Acta Mater1997，45，： | 1 |
| 15 | Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells显示文摘 | Li L Haynes M P Bender J R | 2003 | Proc Natl Acad Sci USA2003，100，： | 1 |
| 16 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic: Suboxic diagenesis 显示文摘 | FROELICH P N KLINKHAMMER G BENDER M L | 1979 | Geochimica et Cosmochimica Aeta1979，43，： | 1 |
| 17 | Global carbon sinks and their variability inferred ftom atmospheric Oz and delta ^13 C显示文摘 | Battle M Bender M L Tans P P | 2000 | Science2000，287，： | 1 |
| 18 | Creation of a bacterial cell controlled by a chemically synthesized genome 显示文摘 | Gibson D G Glass J I Lartigue C Noskov V N Chuang R Y Algire M A Benders G A Montague M G Ma L Moodie M M Merryman C Vashee S Krishnakumar R Assad-Garcia N Andrews-Pfannkoch C Denisova E A Young L Qi Z Q Segall-Shapiro T H Calvey C H Parmar P P Hutchison C A Smith H O Venter J C | 2010 | Science2010，329，5987： | 1 |
| 19 | Lunar Laser Ranging: a Continuing Legacy of the Apollo Program显示文摘 | Dickey J O Bender P L Faller J E | 1994 | Science1994，265，： | 1 |
| 20 | Lunar laser ranging: a continuing legacy of the Apollo program 显示文摘 | P L Bender J E Faller | 1994 | Science1994，265，： | 1 |
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