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| 1 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 4 | Optical fiber Bragg gratings for tunnel surveillance显示文摘 | NELLEN P M FRANK A BRONNIMANN R | 2000 | SPIE2000，3986，： | 2 |
| 5 | A conformationally sensitive GHR antibody : impact on GH signaling and GHR proteolysis显示文摘 | Jiang J Wang X He K Li X Chen C M Sayeski P P Waters M J Frank S J | 2004 | Mol Endocrinol2004，18，12： | 1 |
| 6 | Analysis and synthesis of nonlinear time-delay system via fuzzy control approach显示文摘 | Cao Y Y Frank P M | 2000 | IEEE Transaction on Fuzzy Systems2000，8，2： | 1 |
| 7 | Improvement of mold-level control using fuzzy logic显示文摘 | P M Frank J Wochnik | 1994 | Eng Appl of Artif Intell1994，7，5： | 1 |
| 8 | MAAN:A Multi-attribute Addressable Network for Grid Information Services显示文摘 | Cai Min Frank M Szekely P | 2004 | Journal of Grid Computing2004，2，1： | 1 |
| 9 | Fault diagnosis in dynamic systems using analytical and knowledge-based redundancy-a survey and some new results显示文摘 | Frank P M | 1990 | Automatica1990，26，3： | 1 |
| 10 | Fault Diagnosis in Dynamic System Using Analytical and Knowledge based Redudency A Survey and Some New Results 显示文摘 | FRANK P M | 1990 | Automatic1990，21，3： | 1 |
| 11 | Fault diagnosis in dynamic systems using analytical and knowledge-based redundancy-a survey and some new results显示文摘 | FRANK P M | | 0，，03： | 1 |
| 12 | Degeneration modle of porcine lumbar motion segment : Effects of various intradiscal procedure 显示文摘 | Pfeiffer M Griss P Frank P | 1994 | Eur Spine J1994，38，： | 1 |
| 13 | Stability analysis and synthesis of nonlinear time-delay systems via linear Takagi-Sugeno fuzzy models显示文摘 | Cao Y Y Frank P M | 2001 | Fuzzy Sets and Systems2001，124，2： | 1 |
| 14 | Strong tracking filtering of nonlinear time-varying stochastic systems with colored noise: application to parameter estimation and empirical robustness analysis 显示文摘 | FRANK P M | 1996 | Int J Control1996，65，2： | 1 |
| 15 | Enhancement of robustness in observer-based fault detection 显示文摘 | Frank P M | 1994 | International Journal of Control1994，59，4： | 1 |
| 16 | An algorithmic overview of surface registration techniques for medical imaging显示文摘 | Michel A Frank P Terry M | 2000 | Medical Image Analysis2000，，4： | 1 |
| 17 | Analysis and synthesis of nonlinear time-delay systems via fuzzy control approach显示文摘 | Cao Y Y Frank P M | 2000 | IEEE Transactions on Fuzzy Systems2000，8，2： | 1 |
| 18 | Urban air quality in larger conurbations in the European Union显示文摘 | Frank A M Moussiopoulos N Sahm P | | 0，，： | 1 |
| 19 | Analytical and qualitative model-based fault diagnosis:a survey and some new results显示文摘 | FRANK P M | | 0，，02： | 1 |
| 20 | Survey of robust residual generation and evaluation methods in observer-based fault detection systems 显示文摘 | Frank P M Ding X | 1997 | Journal of Process Control1997，7，6： | 1 |
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