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| 1 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 2 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 3 | Quality control measures for lowering the seroconversion rate of hemodialysis patients with hepatitis B or C virus显示文摘BACKGROUND: Hemodialysis (HD) patients are at high risk of infection by hepatitis B virus (HBV) or hepatitis C virus (HCV). The present study was designed to determine the impact of quality control measures on the prevention of transmission of blood-borne viruses. METHODS: A total of 6182 adult maintenance HD patients from all HD units in Zhejiang Province were recruited on January 1, 2007. The baseline demographic and clinical characteristics were recorded and all patients were followed up until death or survival at 4 years later. The Quality Control Standards of Hemodialysis were gradually implemented in HD units. The HBV or HCV seroconversion rates of the recruited patients were calculated and compared every year during the observation period. RESULTS: The prevalence of HBV was 8.3% at the beginning of the study, and 6.6% for HCV. With the implementation of the HD quality control measures, the HBV seroconversion rate tended to decrease year by year (χ 2 =6.620, P=0.085), and the HCV seroconversion rate decreased significantly (χ 2 =10.41, P=0.015). Compared with the data in 2007, the HBV seroconversion rate (χ 2 =4.204, P=0.040, relative risk ratio 0.393, 95% CI 0.156-0.991) and the HCV seroconversion rate (χ 2 =7.373, P=0.007, relative risk ratio 0.386, 95% CI 0.189-0.787) decreased significantly in 2010. CONCLUSION: Quality control measures for HD decreased the seroconversion rates of HBV or HCV in HD patients, showing that updated quality control measures reduce the risk for transmission of blood-borne viruses in the HD population. | Jing Yuan,Yi Yang, Fei Han, Ping Zhang, Xiao-Ying Du, Hua Jiang and Jiang-Hua Chen The Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of Medicine (Yuan J, Yang Y, Han F, Zhang P, Du XY, Jiang H and Chen JH) and Hemodialysis Quality Control Center of Zhejiang Province (Yuan J, Zhang P, Du XY and Chen JH), Hangzhou 310003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 2 |
| 4 | Transcatheter closure of membranous ventricular septal defects with a new nitinol prosthesis in a natural swine model显示文摘 | Gu X P Han Y M Titus J L | 2000 | Cathete Cardiovasc Intervent2000，50，4： | 2 |
| 5 | Ohmic contact properties of multi-metal films on n-type 4H-SiC显示文摘 | Yang Y T Wang P | 2007 | Chinese Journal of Semiconductors2007，28，2： | 1 |
| 6 | Postnatal development of interstitial cells of Cajal in mouse colon in response to Kit signal blockade with Imatinib(Glivec) 显示文摘 | Han J Zhou Y P Jiang Y Z | 2010 | Acta Histochem2010，112，3： | 1 |
| 7 | Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with Gefitinib显示文摘 | HAN S W KIM T Y HWANG P G | 2005 | J Clin Oncol2005，23，11： | 1 |
| 8 | Effects of Decreasing the Frequency of Ventilator Circuit Changes to Every 7 Days on the Rate of Ventilator-Associated Pneumonia in a Beijing Hospital显示文摘 | Han J N Liu Y P Ma S | 2001 | Respir Care2001，46，9： | 1 |
| 9 | A method for color image seg- mentation based on color similarity coefficient显示文摘 | Han X W Yang Z Li Y P | 2004 | Journal of Shenyang University2004，16，6： | 1 |
| 10 | Total factor carbon e-mission performance; a malmquist index analysis显示文摘 | ZHOU P ANG B W HAN J Y | 2010 | En-ergy Economics2010，32，1： | 1 |
| 11 | Clinical outcomes after lumbar discectomy for sciatica: the effects of fragment type and anular competence显示文摘 | Carragee E J Han M Y Suen P W | 2003 | J Bone Joint Surg Am2003，85，1： | 1 |
| 12 | Total factor carbon emission performance: a malmquist index analysis显示文摘 | Zhou P Ang B W Han J Y | 2010 | Energy Economics2010，32，1： | 1 |
| 13 | Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential 显示文摘 | Li Q H Rehae M Han P Y | 2008 | Molecular Vision2008，14，： | 1 |
| 14 | Design of high power permanent magnet motor with segment rectangular copper wire and closed slot opening on electric vehicles显示文摘 | Choi J H Chtm Y D Han P W | 2010 | IEEE Transactions on Magnetics2010，46，6： | 1 |
| 15 | Significant Acidification in major Chinese croplands显示文摘 | Guo JH Liu X J Zhang Y Shen JL Han WX Zhang WF Christie P Goulding KWT Vitousek PM Zhang FS | 2010 | Science2010，327，： | 1 |
| 16 | Multivariate analysis of heavy metal contamination in urban dust of Xi' an, Central China 显示文摘 | Han Y M Du P X Cao J J Eric S P | 2006 | Science of the Total Environment2006，355，13： | 1 |
| 17 | A general low-tem- perature route for large-scale fabrication of highly oriented ZnO nanorod/nanotube arrays显示文摘 | Yu H D Zhang Z P Han M Y | 2005 | J Am Chem Soc2005，127，8： | 1 |
| 18 | Total Factor Carbon Emission Performance: A Malmquist Index Analysis 显示文摘 | Zhou P Ang ]3 W Han J Y | 2010 | Energy Economics2010，32，1： | 1 |
| 19 | 9 Nitrocamptothecin显示文摘 | Pantazis P Han Z Y Chatterjee D | 1999 | Drug Fut1999，24，12： | 1 |
| 20 | Multivariate analysis of heavy metal contamination in urban dusts of Xi'an, Central China 显示文摘 | Han Y M Du P X Cao J J | 2006 | Science of the Total Environment2006，355，： | 1 |
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