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| 1 | 二氢嘧啶脱氢酶、胸苷酸合成酶、c-myc和p53基因在小鼠肝组织中表达的昼夜节律性研究(英文)显示文摘背景与目的:5-Fluorouracil(5-FU)主要通过抑制胸苷酸合成酶发挥抗癌作用,而二氢嘧啶脱氢酶是5-FU体内代谢的一个起始酶和限速酶。在本研究中,我们对二氢嘧啶脱氢酶、胸苷酸合成酶、c-myc和p53基因在小鼠肝脏中表达的昼夜节律进行研究。方法:本实验共采用了24只雄性B6D2F1小鼠。所有实验动物在实验中进行了4周光照同步化(12h光照:12h黑暗)。体温和休息-活动节律通过腹腔埋置的微型感受器进行动态监测。动物分别在3,7,11,15,19,23HALO(灯亮后小时数)被处死并取出肝脏冻存。肝脏标本中抽提的总RNA用LightCycler-SYBRGreenITM扩增系统进行实时定量RT-PCR。结果:小鼠的体温和休息-活动均呈现明显和相似的昼夜节律,其峰值均位于黑暗期(相当于小鼠活动相),谷值则位于光照期(相当于小鼠休息相)。二氢嘧啶脱氢酶在mRNA水平呈现出明显的昼夜节律性,其峰值时间位于16HALO左右即位于小鼠活动相(P=0.0012)。胸苷酸合成酶在mRNA水平具有昼夜节律表达的趋势,其峰值时间出现在光照期(P=0.079)。C-myc和p53在mRNA水平的节律性表达在本实验中无统计学意义。结论:二氢嘧啶脱氢酶和胸苷酸合成酶在mRNA水平呈现出昼夜节律性,二者峰值时间相差约12h,这一结果提示可以利用二者在转录水平的时间差异用5-FU进行时间化疗。 | 吴明玮 冼励坚 李晓梅 lnnominato Pasquale lvi Francis | 2004 | 癌症2004，23，3： | 22 |
| 2 | Psychopathological aspects of kidney transplantation: Efficacy of a multidisciplinary team显示文摘Renal transplantation is a well established treatment for end-stage renal disease, allowing most patients to return to a satisfactory quality of life. Studies have identified many problems that may affect adaptation to the transplanted condition and postoperative compliance. The psychological implications of transplantation have important consequences even on strictly physical aspects. Organ transplantation is very challenging for the patient and acts as an intense stressor stimulus to which the patient reacts with neurotransmitter and endocrine-metabolic changes. Transplantation can result in a psychosomatic crisis that requires the patient to mobilize all bio-psychosocial resources during the process of adaptation to the new foreign organ which may result in an alteration in self-representation and identity, with possible psychopathologic repercussions. These reactions are feasible in mental disorders, e.g., post-traumatic stress disorder, adjustment disorder, and psychosomatic disorders. In organ transplantation, the fruitful collaboration between professionals with diverse scientific expertise, calls for both a guarantee for mental health and greater effectiveness in challenging treatments for a viable association between patients, family members and doctors. Integrated and multidisciplinary care should include uniform criteria and procedures for standard assessments, for patient autonomy, adherence to therapy, new coping strategies and the adoption of more appropriate lifestyles. | Concetta De Pasquale Massimiliano Veroux Luisa Indelicato Nunzia Sinagra Alessia Giaquinta Michele Fornaro Pierfrancesco Veroux Maria L Pistorio | 2014 | World Journal of Transplantation2014，4，4： | 3 |
| 3 | Pathologic features of Hashimoto’s-associated papillary thyroid carcinomas显示文摘 | Marcello Di Pasquale Jay L Rothstein Juan P Palazzo | 2001 | Human Pathology2001，，1： | 2 |
| 4 | A novel mutation in the BMP15 gene causing defective protein secretion is associated with both increased ovulation rate and sterility in Lacaune sheep显示文摘 | Bodin L Di Pasquale E Fabre S | 2007 | Endocrinology2007，148，1： | 1 |
| 5 | Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/or NSAIDs hypersensitivity 显示文摘 | MARIA L P GABRIELE D L PASQUALE M | 2006 | Mediators Inflamm2006，，62： | 1 |
| 6 | A novel mutation in the BMP15 gene causing defective protein secretion is associat- ed with both increased ovulation rate and sterility in Lacaune sheep 显示文摘 | Bodin L Di Pasquale E Fabre S | 2007 | Endocrinology2007，148，1： | 1 |
| 7 | Novel oral anticoagu- lants and valvular atrial fibrillation: are they always con- traindicated?显示文摘 | Di Pasquale G Zagnoni S Riva L | 2015 | Intern Emerg Med2015，10，1： | 1 |
| 8 | Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene显示文摘 | Di Pasquale E Beck-Peccoz P Persani L | 2004 | Am J Hum Genet2004，75，1： | 1 |
| 9 | A novel mutation in the bone morphogenetic protein 15 gene causing defective protein secretion is associated with both increased ovulation rate and sterility in Lacaune sheep显示文摘 | Bodin L Di Pasquale E Fabre S | 2007 | Endocrinology2007，148，1： | 1 |
| 10 | Berth planning and resources optimization at a container terminal via discrete event simulation显示文摘 | Pasquale L Rina M M | 2001 | European Journal of Operational Research2001，133，3： | 1 |
| 11 | A novel mutation in the BMP15 gene causing defective protein secretion is associated with both increased ovulation rate and sterility in Lacaune sheep显示文摘 | Bodin L Di Pasquale E Fabre S | 2007 | Endocrinology2007，148，1： | 1 |
| 12 | Bean seed performance under different osmotic potentials显示文摘 | Moraes G A F Menezes N L Pasqualli L L | 2005 | Ciencia Rural2005，35，4： | 1 |
| 13 | Muhicenter, random- ized, prospective trial of early tracheostomy显示文摘 | Sugerman HJ Wolfe L Pasquale MD | 1997 | J Trauma1997，43，5： | 1 |
| 14 | Potential toxicity of mitomycin C显示文摘 | DERICK R J PASQUALE L QUIGLEY H A | 1991 | Arch Ophthalmol1991，109，12： | 1 |
| 15 | 6- Chloro-2,3-dihydro-4H-1-benzopyran carboxylic acids: synthesis, optical resolution and absolute configuration 显示文摘 | FULVIO L ANTONIO L PASQUALE B | 1995 | Tetrahedron:Asmmetry1995，6，4： | 1 |
| 16 | Intra-operative testing for parathyroid hormone; the Central Laboratory option显示文摘 | De Pasquale L Gobatti D Ravini ML | 2008 | J Endocrinol Invest2008，31，： | 1 |
| 17 | Modeling and solving rich quay crane scheduling problems显示文摘 | Pasquale L Roberto T Frank M | 2012 | Computers & Operations Research2012，39，： | 1 |
| 18 | Efficacy of rescue thrombolysis in patients with acute myocardial infarction: preliminary findings显示文摘 | Sarullo FM Americo L Di Pasquale P | 2000 | Cardiovas Drugs Ther2000，14，1： | 1 |
| 19 | Primary cerebral lymphomatoid granulomatosis: report of four cases and literature review 显示文摘 | Corrado L Pasquale D B Francesco D | 2009 | J Neurooncol2009，94，2： | 1 |
| 20 | The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders 显示文摘 | Persani L Rossetti R Di Pasquale E | 2014 | Hum Reprorl Update2014，20，6： | 1 |
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