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| 1 | A novel motion tracking system for evaluation of functional rehabilitation of the upper limbs显示文摘Upper limb function impairment is one of the most common sequelae of central nervous system injury, especially in stroke patients and when spinal cord injury produces tetraplegia. Conventional assessment methods cannot provide objective evaluation of patient performance and the effectiveness of therapies. The most common assessment tools are based on rating scales, which are inefficient when measuring small changes and can yield subjective bias. In this study, we designed an inertial sensor-based monitoring system composed of five sensors to measure and analyze the complex movements of the upper limbs, which are common in activities of daily living. We developed a kinematic model with nine degrees of freedom to analyze upper limb and head movements in three dimensions. This system was then validated using a commercial optoelectronic system. These findings suggest that an inertial sensor-based motion tracking system can be used in patients who have upper limb impairment through data integration with a virtual reality-based neurorehabilitation system. | ngel Gil-Agudo Ana de los Reyes-Guzmán Iris Dimbwadyo-Terrer Benito Peasco-Martín Alberto Bernal-Sahún Patricia López-Monteagudo Antonio del Ama-Espinosa José Luis Pons | 2013 | Neural Regeneration Research2013，8，19： | 3 |
| 2 | Silent diabetic nephropathy显示文摘AIM: To examine the risk of renal events in patients with biopsy-proven diabetic nephropathy(DN) and its possible associated factors.METHODS: Clinical and histological data of 60 patients diagnosed with diabetic nephropathy were retrospectively collected. Patients with evidence or suspicion of other nephropathies were excluded from the study. The final event was defined as renal replacement therapy(RRT) initiation or progression of chronic kidney disease(CKD), according to the KDIGO 2012 definition of a decrease in CKD category and a decrease in GFR of 25% or more. RESULTS: A total of 45 patients with a follow-up of at least 3 mo were included. Most of the patients presented type 2 DM, with a median age of 58.3 years old. The time of evolution of DM was 9.6 ± 7.8 years, although in 13 patients, it was less than 5 years. A total of 62% of patients reached the final event in a mean period of 3.4 years(95%CI: 2.1-4.7), with 21 of them requiring dialysis. The factors that were independently associated with renal survival were estimated glomerular filtration rate(e GFR) at the time of biopsy, cardiovascular disease(CVD) history and Hb A1 c less than 7%. Therefore, for each 10 m L/min per 1.73 m2 reduction in e GFR, we obtained a DN progression risk of HR = 2(1.3-3.0)(P = 0.001); patients with CVD were at greater risk for DN progression(HR = 2.8, 1.1-7.1, P = 0.032), and CKD patients with Hb A1 c < 7% demonstrated greater renal risk than patients with Hb A1 c ≥ 7%, with an HR of 2.9(1.0-8.4)(P = 0.054).CONCLUSION: A past history of CVD is a risk factor for DN progression. Levels of Hb A1 c less than 7% could favor an e GFR decrease in these patients. | Katia López-Revuelta Patricia Pea Galdo Ramona Stanescu Leticia Parejo Carmen Guerrero Elia Pérez-Fernández | 2014 | World Journal of Nephrology2014，3，1： | 2 |
| 3 | Nuclear co-expression of p14 ^{ARF} and p16 ^{INK4A} in uterine cervical cancer-derived cell lines containing HPV显示文摘 | Salvador Vázquez-Vega Lilia Patricia Sánchez-Suárez Adriana Contreras-Paredes Emilio Castellanos-Juárez Rubicelia Pe?arroja-Flores Marcela Lizano-Soberón Rafael Andrade-Cruz Alejandro García-Carrancá Luis Benítez-Bribiesca | 2010 | Cancer Biomarkers2010，，6： | 1 |
| 4 | Effects of long-term experimental night-time warming and drought on photosynthesis, Fv/Fm and stomatal conductance in the dominant species of a Mediterranean shrubland显示文摘 | Patricia Prieto Josep Pe?uelas Joan Llusià Dolores Asensio Marc Estiarte | 2009 | Acta Physiologiae Plantarum2009，，4： | 1 |
| 5 | Different contribution of BH3-only proteins and caspases to doxorubicin-induced apoptosis in p53-deficient leukemia cells显示文摘 | NURIA LO'PEZ-ROYUELA A PATRICIA PE' REZ-GALA' N B PATRICIA GALA'N-MALO | 2010 | Biochem Pharmaeol2010，79，： | 1 |
| 6 | Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol显示文摘 | Patricia Cogram Andrew Hynes Louisa PE Dunlevy | 2004 | Human Molecular Genetics2004，13，1： | 1 |
| 7 | New injectable two-step forming hydrogel for delivery of bioactive substances in tissue regeneration显示文摘A hydrogel based on chitosan,collagen,hydroxypropyl-c-cyclodextrin and polyethylene glycol was developed and characterized.The incorporation of nano-hydroxyapatite and pre-encapsulated hydrophobic/hydrophilic model drugs diminished the porosity of hydrogel from 81.6262.25%to 69.9863.07%.Interactions between components of hydrogel,demonstrated by FTIR spectroscopy and rheology,generated a network that was able to trap bioactive components and delay the burst delivery.The thixotropic behavior of hydrogel provided adaptability to facilitate its implantation in a minimally invasive way.Release profiles from microspheres included or not in hydrogel revealed a two-phase behavior with a burst-and a controlled-release period.The same release rate for microspheres included or not in the hydrogel in the controlled-release period demonstrated that mass transfer process was controlled by internal diffusion.Effective diffusion coefficients,Deff,that describe internal diffusion inside microspheres,and mass transfer coefficients,h,i.e.the contribution of hydrogel to mass transfer,were determined using‘genetic algorithms’,obtaining values between 2.64·10^(-15) and 6.67·10^(-15)m^(2)/s for Deff and 8.50·10^(-10) to 3.04·10^(-9) m/s for h.The proposed model fits experimental data,obtaining an R2-value ranged between 95.41 and 98.87%.In vitro culture of mesenchymal stem cells in hydrogel showed no manifestations of intolerance or toxicity,observing an intense proliferation of the cells after 7 days,being most of the scaffold surface occupied by living cells. | Edgar Pe´rez-Herrero Patricia Garcı´a-Garcı´a Jaime Go´mez-Morales Matias Llabre´s Araceli Delgado Carmen E´vora | 2019 | Regenerative Biomaterials2019，6，3： | 0 |
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