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| 1 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 2 | A Suggestion for a Simple Cross - Country Empirical Proxy for Trend Unemployment 显示文摘 | Stephen C Murchison Pierre L Siklos | 1999 | Applied Economics Letters1999，，6： | 1 |
| 3 | Critical flux determination by the flux-step method in a submerged membrane bioreactor 显示文摘 | Pierre L C Bruce J Chang I S | 2003 | Journal of Membrane Science2003，227，： | 1 |
| 4 | Fouling in membrane bioreactors used in wastewater treatment 显示文摘 | PIERRE L C VICKI C TONY A G | 2006 | Journal of Membrane Science2006，284，： | 1 |
| 5 | Composition and heavy oil rheology 显示文摘 | Pierre C Barre L Pina A | 2004 | Oil & Gas Scfence and Technology2004，59，5： | 1 |
| 6 | Traveling--wave Excitation and Optical Measurement Techniques for Non--contacting Investigation of Bladed Disk Dynamies显示文摘 | Judge J A Ceccio S L Pierre C | 2003 | The Shock and Vibration Digest2003，35，3： | 1 |
| 7 | Use of electrophoretic mobility and streaming potential measurements to characterize electrokinetic properties of ultrafiltration and microfiltrafion membranes 显示文摘 | Ricq L Pierre A Reggiani J C | 1998 | Colloids Surface A: Physicochem Eng Aspects1998，138，： | 1 |
| 8 | Electrochemical and electrical properties of copper organic complexing films deposited on a platinum electrode显示文摘 | Minh C P Gerard T Pierre C L | 1980 | Electroanal Chem1980，111，： | 1 |
| 9 | Fouling in membrane bioreactors used in wastewater treatment显示文摘 | Pierre L C C Tony A G F | 2006 | Membrane Science2006，284，34： | 1 |
| 10 | Masked hypertension:a systematic review显示文摘 | Guillaume B Pierre C Jol M | 2008 | J Hypertens2008，26，9： | 1 |
| 11 | Isotope Study on Diffusionin CaS04 Formed During Sorbent-Flue-Gas Reaction显示文摘 | Hsia C St Pierre G R Fan L S | 1995 | AIChE Journal1995，41，10： | 1 |
| 12 | Fouling in membrane bioreactors used inwastewaterreatment显示文摘 | PIERRE L C CHEN V FANE T A G | 2006 | J MembrSci2006，284，： | 1 |
| 13 | Activity and safety of the antiestrogen EM-800, the orally active precursor of acolbifene,in tamoxifen-resistant breast cancer显示文摘 | Fernand L Pierre C Claude L | 2004 | J Clin Oncol2004，22，5： | 1 |
| 14 | Use of electrophoretic mobility and streaming potential measurements to characterize electrokinetic properties of ultrafiltration and microfiltration membranes 显示文摘 | Ricq L Pierre A Reggiani J C | 1998 | Colloids and Surfaces A: Physicochemical and Engineering Aspects1998，138，2： | 1 |
| 15 | Isotope study on diffusion in CaSO4 formed during sorhent-flue-gas reaction 显示文摘 | Hsia C Pierre G R Fan L S | 1995 | AIChE Journal1995，41，10： | 1 |
| 16 | Ototoxicity of the three xylene isomers in the rat显示文摘 | Katy M Robert L Pierre C | 2006 | Neurotoxicol Teratol2006，28，： | 1 |
| 17 | Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis显示文摘 | Pierre Blanchard Anne Lee Sophie Marguet Julie Leclercq Wai Tong Ng Jun Ma Anthony T C Chan Pei-Yu Huang Ellen Benhamou Guopei Zhu Daniel T T Chua Yong Chen Hai-Qiang Mai Dora L W Kwong Shie Lee Cheah James Moon Yuk Tung Kwan-Hwa Chi George Fountzilas Li | 2015 | The Lancet Oncology2015，，： | 1 |
| 18 | Using the theoryof planned behavior to identify key beliefs underlying pro-environmentalbehavior in high-school students : Implications for educationalinterventions显示文摘 | ASTRID D L PIERRE VB AJZEN C SCHMIDT P | 2015 | Journal of Environmental Psychology2015，42，3： | 1 |
| 19 | Fouling in membrane bioreactors used in wasterwater treatment显示文摘 | PIERRE L VICKI C TONY A | 2006 | Journal of Membrane Science2006，284，12： | 1 |
| 20 | Modified montmorillonite clay:a new heterogeneous catalyst for nitration of arenes显示文摘 | Barb S G Pierre L Ander C | 2014 | Catalysis Communications2014，57，8： | 1 |
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