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75篇 您的检索式:作者名="PIQU M"
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1New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis.Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel 2014World Journal of Gastroenterology2014,20,8:3
2Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘Antonio M Lacy Juan C García-Valdecasas Salvadora Delgado Antoni Castells Pilar Taurá Josep M Piqué Josep Visa 20022002 (9325)2002,,9325:3
3Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘Antonio M Lacy Juan C García-Valdecasas Salvadora Delgado Antoni Castells Pilar Taurá Josep M Piqué Josep Visa 2002The Lancet2002,,9325:2
4Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘Antonio M Lacy Juan C García-Valdecasas Salvadora Delgado Antoni Castells Pilar Taurá Josep M Piqué Josep Visa 2002The Lancet2002,,9325:2
5Aspirin and salicylate induced apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells显示文摘Bellosillo B Pique M Barragan M Castano E Villamor N Colomer D 1998Blood1998,92,:1
6Influence of cold-storage conditions on the quality of unshelled walnuts显示文摘Lopez A Pique M T Romero A 1995Int J Refrig1995,18,8:1
7Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition 显示文摘Pizcueta P Pique JM Fernandez M 1992Gastroenterology1992,103,6:1
8The vaso-lidation role of endogenous nitric oxide in the rat gastric microcirctdation 显示文摘Pique J M Whittle B J R Esphigues T V 1989Eur J Pharmacol1989,17,:1
9Overstory structure and top ographic gradients determining diversity and abun- dance of understory shrub species in temperate forests in central Pyrenees( NE Spain) 显示文摘Gracia M Montane F Pique J 2007Forest Ecology and Man- agement2007,242,23:1
10Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘Antonio M Lacy Juan C García-Valdecasas Salvadora Delgado Antoni Castells Pilar Taurá Josep M Piqué Josep Visa 2002The Lancet . 2002 (9325)2002,,:1
11Influence of cold stronger conditions on the quality of unshelled walnuts显示文摘LOPEZ A PIQUE M T ROMERO A 1995International Journal of Refrigeration1995,18,8:1
12Overstory structure and topographic gradients determining diversity and abundance of understory shrub species in temperate forests in central Pyrenees (NE Spain ) 显示文摘Gracia M Montane F Pique J 2007Forest Ecology and Management2007,242,23:1
13Prodigiosin from the supernatant of Serratia marcescens induces apoptosis in haematopoietic cancer cell lines显示文摘MONTANER B NAVARRO S PIQUM 2000Br J Pharmacol2000,131,:1
14Type IV pilin structure and assembly:X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin显示文摘Craig L Taylor R K Pique M E 2003Mol Cell2003,11,5:1
15Influence of cold-storage conditions on the quality of unshelled walnuts显示文摘Lopez A Pique M Romero A 1995International Journal of Refrigeration1995,18,8:1
16Aspirin induces apoptosis through mitochondrial cytochrome c release显示文摘Pique M Barragan M Dalmau M 2000FEBS Lett2000,480,23:1
17Prodigiosin from the supernatant of Serratia marcescens induces apoptesis in haematopoietic cancer cell lines显示文摘MONTANER B NAVARRO S PIQU M 2000Br J Pharmacol2000,131,:1
18Low concentrations of 1-methyl-4-phenylpyridinium ion induce caspase-mediaated apoptosis in human SH-SY5Y neuroblastoma cells显示文摘Gomez C Reiriz J Pique M 2001J Neurosci Res2001,63,5:1
19Overstory structure and topographic gradients determining diversity and abundance of understory shrub species in temperate forests in central Pyrenees (NE Spain)显示文摘Gracia M Montan E F Piqu E J 2007Forest Ecology and Management2007,242,23:1
20Type IV pilus structure and bacterial pathogenicity显示文摘Craig L Pique M E Tainer J A 2004Nat Rev Microbiol2004,2,:1
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