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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | NMR characterization of altered lignins extracted from tobacco plants down-regulated for lignification enzymes cinnamylalcohol dehydrogenase and cinnamoyl-CoA reductase显示文摘 | RALPH J HATFIELD R D PIQUEMAL J | 1998 | Proc Natl Acad Sci USA1998，95，12： | 1 |
| 3 | Buflomedil poisoning:five cases with cardiotoxicity显示文摘 | Legras A Piquemal R Furet Y | 1996 | Intensive Care Med1996，22，1： | 1 |
| 4 | Polarizable Molecular Dynamics Simulation of Zn(Ⅱ)in Water Using the AMOEBA Force Field 显示文摘 | J C Wu J P Piquemal R Chaudert | 2010 | J Chem Theory Comput2010，6，7： | 1 |
| 5 | NMR characterization of altered lignins extracted from tobacco plants down-regulated for lignification enzymes cinnamylalcobol dehydrogenase and cinnamoyl-CoA reductase显示文摘 | Ralph J Hatfieid R D Piquemal J | 1998 | Proceedings of the National Academy of Sciences of the United States of America1998，95，12： | 1 |
| 6 | Ranola- zine poisoning : five cases with cardiotoxicity 显示文摘 | LEGRAS A PIQUEMAL R FURET Y | 1996 | In- tensive Care Med1996，22，4： | 1 |
| 7 | Catalytic epoxidation by heteropolyoxoperoxo complexes:From novel precursors or catalysts to a mechanistic approach显示文摘 | SALLES L PIQUEMAL J-Y THOUVENOT R | 1997 | J Mol Catal A:Chem1997，117，： | 1 |
| 8 | Catalytic ep-oxidation by heteropolyoxoperoxo complexes: from novelprecursors or catalysts to a mechanistic approach显示文摘 | Salles L Piquemal J Y Thouvenot R | 1997 | J MolCatal A1997，117，： | 1 |
| 9 | Buflomedil poisoning : five cases with cardiotoxicity显示文摘 | Legras A Piquemal R Furet Y | 1996 | Intensive Care Med1996，22，1： | 1 |
| 10 | Doppler tissue imaging of the myocardium and right ventricle显示文摘 | Selton Suty C Mock L Piquemal R | 2002 | Arch Mal Coeur Vaiss2002，95，10： | 1 |
| 11 | Buflomedil poisoning: five caseswith cardiotoxicity显示文摘 | Legras A Piquemal R Furet Y | 1996 | Intensive Care Med1996，22，1： | 1 |
| 12 | Polarizable molecular dynamics simulation of Zn( II ) in water using the AMOE- BA force field显示文摘 | WU J C PIQUEMAL J P CHAUDRET R | 2010 | J Chem Theory Comput2010，6，7： | 1 |
| 13 | NMR characterization of altered lignins extracted from tobacco plants down-regulated for lignification enzymes cinnamyl-alcohol dehydrogenase and cinnamoyl-CoA reductase显示文摘 | Ralph J Hatfield R D Piquemal J | 1998 | Proc Natl Acad Sci USA1998，95，12： | 1 |
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