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23篇 您的检索式:作者名="POLLARD A L"
    题名 作者 年代 出处 被引量
1Comparison of 3 techniques for ureteroneocystostomy in cats显示文摘Mehl M L Kyles A E Pollard R 2005Vet Surg2005,34,:1
2查看详情显示文摘Pollard J A Zhang D S Downing J A Knorr F J McHale J L J 0,,:1
3Not all arrestins are created equal: Therapeutic implications of the functional diversity of the β-arrestins in the heart显示文摘The two ubiquitous, outside the retina, G protein-coupled receptor(GPCR)adapter proteins, β-arrestin-1 and-2(also known as arrestin-2 and-3,respectively), have three major functions in cells: GPCR desensitization, i.e.,receptor decoupling from G-proteins; GPCR internalization via clathrin-coated pits; and signal transduction independently of or in parallel to G-proteins. Bothβ-arrestins are expressed in the heart and regulate a large number of cardiac GPCRs. The latter constitute the single most commonly targeted receptor class by Food and Drug Administration-approved cardiovascular drugs, with about onethird of all currently used in the clinic medications affecting GPCR function.Since β-arrestin-1 and-2 play important roles in signaling and function of several GPCRs, in particular of adrenergic receptors and angiotensin II type 1 receptors,in cardiac myocytes, they have been a major focus of cardiac biology research in recent years. Perhaps the most significant realization coming out of their studies is that these two GPCR adapter proteins, initially thought of as functionally interchangeable, actually exert diametrically opposite effects in the mammalian myocardium. Specifically, the most abundant of the two β-arrestin-1 exerts overall detrimental effects on the heart, such as negative inotropy and promotion of adverse remodeling post-myocardial infarction(MI). In contrast, β-arrestin-2 is overall beneficial for the myocardium, as it has anti-apoptotic and antiinflammatory effects that result in attenuation of post-MI adverse remodeling,while promoting cardiac contractile function. Thus, design of novel cardiac GPCRligands that preferentially activate β-arrestin-2 over β-arrestin-1 has the potential of generating novel cardiovascular therapeutics for heart failure and other heart diseases.Anastasios Lymperopoulos Shelby L Wertz Celina M Pollard Victoria L Desimine Jennifer Maning Katie A McCrink 2019World Journal of Cardiology2019,11,2:1
4Evaluation of enzyme-linked immunosorbent assay for the determination of polycyclic aromatic hydrocarbons in house dust and residential soil显示文摘CHUANG J C POLLARD M A CHOU Y L 1998The Science of the Total Environment1998,224,:1
5The calculation of some laminar flows using various discretization schemes 显示文摘POLLARD A SIu A L W 1982Computer Methods in Applied Mechanics and Engineering1982,35,3:1
6The calculation of some laminar flows using various discretization schemes 显示文摘Pollard A Siu A L W 1982Computer Methods in Applied Mechanics and Engineering1982,35,:1
7Characterization and application of activated carbon produced from Moringa oleifera seed usks by single-step steam pyrolysis显示文摘Warhurst A M Me Connachie G L Pollard S J T 1997Water Res1997,31,:1
8Respiratory syncytial virus infections in children and adults显示文摘Collins C L Pollard A J 2002J Infect2002,45,1:1
9Exploitation of adherent neural stem cells in basic and applied neurobiology 显示文摘Pollard S Conti L Smith A 2006Regen Med2006,1,1:1
10Carbon-13 nuclear magnetic resonance of 5-substituted uracils显示文摘PAUL D E DUNLAP R B POLLARD A L 1973J Am Chem Soc1973,95,:1
11Economic benefits at- tributed to opening a preoperative evaluation clinic for out- patients显示文摘Pollard J B Zboray A L Mazze R I 1996Anesthesia and Analgesia1996,,83:1
12A Review of Recent Artificial Reef Developments in Australia显示文摘Branden K L Pollard D A Reimers H A 1994Bulletin of Marine Science1994,55,23:1
13A review of recent artificial reef Developments in Australia 显示文摘BRAND K L POLLARD D A REMERS H A 1994Bulletin of marine science1994,55,23:1
14Investigating the effects of reduced size on the properties of ferroelectrics显示文摘Saad M M Baxter P McAneney J Lookman A Sinnamon L J Evans P Schilling A Adams T Zhu X H Pollard R J Bowman R M Gregg J M Jung D J Morrison F D Scott J F 2006IEEE Trans Ultrason Ferroelect Freq Contr l2006,53,:1
15Characterisation and applications of activated carbon produced from Moringa oleifera seed husks by single-step steam pyrolysis 显示文摘Warhurst A Michael McConnachie Gordon L Pollard Simon J T 1997Water Resource1997,31,4:1
16Maerophage biology in devel- opment, homeostasis and disease 显示文摘Wynn T A Chawla L Pollard J W 2013Nature2013,496,7446:1
17Peripartum myocardial ischemia:a review of Canadian deliveries from 1970 to 1998显示文摘Macarthur A Cook L Pollard J K 2006Am J Obstet Gynecol2006,194,:1
18The calculation of some laminar flows using various discrimination schemes显示文摘Pollard A Siu A L W 1982Comput Math Appl Mech Eng1982,35,:1
19A model of carbon evasion and sedimentation in temperate lakes 显示文摘Hanson P C Pollard A I Bade D L 2004Global Change Biology2004,10,:1
20Multi element analysis of iron ore pellets by laser-induced breakdown spectroscopy and principal components regression显示文摘Death D L Cunningham A P Pollard L J 2008Spectrochimica Acta Part B2008,63,7:1
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