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| 1 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | Characterization of bacteriocin ST8KF produced by a kefir isolate Lactobacillus plant arum ST8KF 显示文摘 | Powell J Witthuhna R Todorovb S | 2007 | International Dairy Journal2007，17，2： | 1 |
| 4 | Introduction of gaseous hydrides into an inductively coupled plasma mass spectrometer显示文摘 | POWELL M J BOOMER D W MCVICARS R J | 1986 | Analytical Chemistry1986，58，13： | 1 |
| 5 | Gene length and codon us age bias in Drosophila raelanogaster, SaccharomS, ces cerevisiae and Escherichia coli显示文摘 | Moriyama E N Powell J R | 1998 | Nucleic Acids Res1998，26，13： | 1 |
| 6 | Radiofrequency volumetrictissue reduction of the palate in subjects with sleep-disorderedbreathing显示文摘 | Powell N B Riley R W Troell R J | 1998 | Chest1998，113，： | 1 |
| 7 | Antibiotic prophy- laxis in the initial management of severe acute pancreations显示文摘 | POWELL J J MILES R SIRIWARDENA AK | | Br J Surg0，85，5： | 1 |
| 8 | BRCA1 and BRCA2 : different rolesin a common pathway of genome protection 显示文摘 | Roy R Chun J Powell SN | 2012 | Nat Rev Cancer2012，，1： | 1 |
| 9 | Granulomtous enterocolitis induced in rat by purified bacterial cell wall fragmentals显示文摘 | CROMARTIE W J POWELL D W | 1985 | Gastroenterology1985，89，： | 1 |
| 10 | Influence of LCF overloads on combined HCF/LCF crack growth 显示文摘 | Byrne J Hall R F Powell B E | 2003 | International Journal of Fatigue2003，25，911： | 1 |
| 11 | Modern tidal rhythmites deposited in a deep-water estuaty显示文摘 | Cowan E A Cai J Powell R D | 1998 | Geo-marine Letters1998，18，： | 1 |
| 12 | A low-cost GPS/inertial attitude heading reference system (AHRS) for general aviation applications显示文摘 | Gebre-Egziabher D Hayward R C Powell J D | 1998 | IEEE Position Location and Navigation Symposium1998，，： | 1 |
| 13 | LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporterl (SGLT1)- mediated absorption of intestinal glucose 显示文摘 | Powell D R Smith M Greer J | 2013 | J Pharmacol Exp Ther2013，345，2： | 1 |
| 14 | Improved classification of conservation tillage adoption using high temporal and synthetic satellite imagery显示文摘 | Watts J D Powell S L Lawrence R L | 2011 | Remote Sensing of Environment2011，115，1： | 1 |
| 15 | Fast evaluation ofpolyharmonic splines in three dimensions显示文摘 | Beatson R K Powell M J D Tan A M | 2006 | IMA Jour-nal of Numerical Analysis2006，27，3： | 1 |
| 16 | Take it to the limit: Innovative CVaR applications to extreme credit risk measurement 显示文摘 | ALLEN D E POWELL R J | 2016 | European Journal of Operational Research2016，249，2： | 1 |
| 17 | Design of Multi- Sensor Attitude Determination Systems 显示文摘 | Gebre Egziabher D HayWard R C Powell J D | 2004 | IEEE Transactions on Aerospace and Electronic System2004，40，2： | 1 |
| 18 | The application of in situpermeable reactive (zero- valent iron) barrier technologyfor the remediation of chromate- contaminated groundwater : a field test显示文摘 | Puls R W Paul C J Powell R M | 1999 | Appl Geochem1999，14，： | 1 |
| 19 | The solubilities of lanthanum chloride7-hydrate and lanthanum chloride 6-hydrate in water,and a study of the thermal decomposition of hydrated lanthanum chloride显示文摘 | Powell J E Burkholder H R | 1960 | Journal of Inorganic and Nuclear Chemistry1960，14，1： | 1 |
| 20 | Design of multi-sensor attitude determination systems 显示文摘 | GEBRE-EGZIABHER D HAYWARD R C POWELL J D | 2004 | IEEE Transactions on Aerospace and Electronic Systems2004，40，2： | 1 |
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