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| 1 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 2 | Comparison of VEGF,VEGF-B,VEGF-C and Ang-1 mRNA regulation by serum,growth factors,oncoproteins and hypoxia显示文摘 | Enholm B Paavonen K Ristimaki A | | 0，，： | 2 |
| 3 | Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women:an interim analysis of a phase Ⅲ double-blind,randomised controlled trial显示文摘 | Paavonen J Jenkins D Bosch FX | 2007 | Lancet2007，369，9580： | 1 |
| 4 | Expression of cyelo-oxygenase-2 in human tongue carcinoma and its precursor lesions 显示文摘 | Renkonen J Wolff H Paavonen Y | 2002 | Virchows Arch2002，440，6： | 1 |
| 5 | Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer显示文摘 | Harris NC Paavonen K Davydova N | | 0，，08： | 1 |
| 6 | Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase Ⅲ double-blind, randomised controlled trial 显示文摘 | Paavonen J Jenkins D Bosch FX | 2007 | Lancet2007，369，9580： | 1 |
| 7 | Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing显示文摘 | Paavonen K Puolakkainen P Jussila L | 2000 | AmJ Pathol2000，156，5： | 1 |
| 8 | Comparison of VEGF , VEGF-B , VEGF-C and Ang-1 mRNA regulation by serum , growth factors, oneoproteins and hypoxia显示文摘 | Enholm B Paavonen K Ristimaki A | 1997 | Oneogene1997，14，20： | 1 |
| 9 | Loop electrosurgical excision procedure and the risk for preterm birth显示文摘 | Jakobsson M Gissler M Paavonen J | 2009 | 0bstet Gynecol2009，114，3： | 1 |
| 10 | Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34,respectively显示文摘 | Horelli-Kuitonen N Chilov D | 1996 | Circulation1996，93，6： | 1 |
| 11 | Novelhuman vascular endothelial growth factor genes VEGF-Band VEGF-C localize to chromosomes 11q13and 4q34,respectively显示文摘 | Paavonen K Horelli-Kuitunen N Chilov D | 1996 | Circulation1996，93，6： | 1 |
| 12 | Decreased risk of symptomatic chlamydial pelvic inflammatory disease associated with oral contraceptive use显示文摘 | Wolner-Hanssen P Eschenbach DA Paavonen J | 1990 | JAMA1990，263，1： | 1 |
| 13 | Efficacy of a prophylac tic adjuvanted bivalent L1 virus-hke-particle vaccine againsl in fection with human papillomavirus types 16 and 18 in young women:an interim analysis of a phase Ⅲ double-blind, random- ised controlled trial显示文摘 | Paavonen J Jenkins D Bosch FX | 2007 | Lancet2007，369，9580： | 1 |
| 14 | Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase显示文摘 | Aino Soro-Paavonen Wei-Zeng Zhang Kylie Venardos Melinda T Coughlan Emma Harris David CK Tong Daniella Brasacchio Karri Paavonen Jaye Chin-Dusting Mark E Cooper David Kaye Merlin C Thomas Josephine M Forbes | 2010 | Journal of Hypertension2010，，4： | 1 |
| 15 | Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction显示文摘 | Kovanen PT Kaartinen M Paavonen T | 1995 | Circulation1995，92，5： | 1 |
| 16 | Human papilloraavirus infection and the development of cervical cancer and related genital neoplasias 显示文摘 | Paavonen J | 2007 | lnt J Infect Dis2007，11，2： | 1 |
| 17 | Mucopurulent cervici- tis the ignored counterpart in women of urethritis in men 显示文摘 | Brunham RC Paavonen J Stevens CE | 1984 | N Engl J Med1984，311，1： | 1 |
| 18 | Novel human vascular endothelial growth factor genes VEGF- B and VEGF- C localize to chromosomes 11 q13 and 4q34, respectively显示文摘 | Paavonen K Horelli-Kuitunen N Chilov D | 1996 | Circulation1996，93，6： | 1 |
| 19 | Efficacy of human papil- lomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervi- cal infection and precancer caused by oncogenic HPV types (PA TRICIA) :final analysis of a double-blind, randomised study in young women显示文摘 | Paavonen J Naud P Salmeron J | 2009 | Lancet2009，34，9686： | 1 |
| 20 | Expression of cyclooxygenase-2 in human tongue carcinoma and its precursor lesions显示文摘 | Renkonen J Wolff H Paavonen T | 2002 | Virchows Arch2002，440，6： | 1 |
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