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| 1 | 5-ASA colonic mucosal concentrations resulting from different pharmaceutical formulations in ulcerative colitis显示文摘AIM:To compare the mucosal concentrations of 5-aminosalicylic acid(5-ASA)resulting from different pharmaceutical formulations and analyse the influence of inflammation on the mucosal concentrations.METHODS:The study included 130 inflammatory bowel disease(IBD)patients receiving 5-ASA as pH-dependent-release formulations(73 patients),time-dependent-release formulations(11 patients),or pro-drugs(18patients).In addition,28 patients were receiving topical treatment(2-4 g/d)with pH-dependent-release formulations.Endoscopic biopsies were obtained from the sigmoid region during the colonoscopy.The 5-ASA concentrations(ng/mg)were measured in tissue homogenatesusing high-pressure liquid chromatography with electrochemical detection.The t test and Mann-Whitney test,when appropriate,were used for statistical analysis.RESULTS:Patients receiving pH-dependent-release formulations showed significantly higher mucosal concentrations of 5-ASA(51.75±5.72 ng/mg)compared with patients receiving pro-drugs(33.35±5.78 ng/mg,P=0.01)or time-dependent-release formulations(38.24±5.53 ng/mg,P=0.04).Patients with endoscopic remission had significantly higher mucosal concentrations of5-ASA than patients with active disease(60.14±7.95ng/mg vs 35.66±5.68 ng/mg,P=0.02).Similar results were obtained when we compared patients with the histological appearance of remission and patients with active histological inflammation(67.53±9.22 ng/mg vs 35.53±5.63 ng/mg,P<0.001).Significantly higher mucosal concentrations of 5-ASA were detected in patients treated with both oral and topical treatments in combination compared with patients who received oral treatment with pH-dependent-release formulations alone(72.33±11.23 ng/mg vs 51.75±5.72 ng/mg,P=0.03).CONCLUSION:IBD patients showed significant variability in mucosal 5-ASA concentrations depending on the type of formulation,and the highest mean concentration was achieved using pH-dependent-release formulations. | Renata D’Incà Martina Paccagnella Romilda Cardin Surajit Pathak Vincenzo Baldo Maria Cecilia Giron Giacomo Carlo Sturniolo | 2013 | World Journal of Gastroenterology2013，19，34： | 4 |
| 2 | Phase Ⅲ trial of initial chemotherapy in stage Ⅲ or Ⅳ head and neck cancers:a study by the Gruppo di Studio sui Tumori della Testa e del Collo显示文摘 | Orlando A Marchiori C | 1994 | J Natl Cancer Inst1994，86，： | 1 |
| 3 | Nutritional intervention for improving treatment tolerance in cancer patients显示文摘 | PACCAGNELLA A MORASSUTTI I ROSTI G | 2011 | Cuit Opin Oncol2011，23，4： | 1 |
| 4 | Randomized phase Ⅲ trial of neoadjuvant chemotherapy in head and neck cancer:10-year followup显示文摘 | Paccagnella A Cavaniglia G | 2004 | J Natl Cancer Inst2004，96，： | 1 |
| 5 | Nutritional intervention for improving treatment tolerance in cancer patients 显示文摘 | Paccagnella A Morassutti I Rosti G | 2011 | Curt Opin Oncol2011，23，4： | 1 |
| 6 | Extramedul- laryplasmacyloma:clinical hehavior and response to treatment 显示文摘 | Soesan M Paccagnella A Chiarion-Sileni V | 1992 | Ann Oncol1992，3，1： | 1 |
| 7 | Effect of ion energy on charge loss from floating gate memories显示文摘 | Cellere G Paccagnella A Visconti A | 2008 | IEEE Transactions on Nuclear Science2008，55，4： | 1 |
| 8 | Aspect ratio calculation in n-channel MOSFETs with a gate-enclosed layout显示文摘 | GIRALDO A PACCAGNELLA A MINZONI A | 2000 | Sol Sta Elec2000，44，7： | 1 |
| 9 | Early nutritional intervention improves treatment tolerance and outcomes in head and neck cancer patients undergoing concurrent chemoradiotherapy 显示文摘 | Paccagnella A Morello M Da Mosto MC | 2010 | Support Care Cancer2010，18，7： | 1 |
| 10 | Cardiac cachexia:preoperative and postoperative nutrition management显示文摘 | PACCAGNELLA A CALO M A CAENARO G | 1994 | JPEN1994，18，5： | 1 |
| 11 | Getting the Seats of Your Pants Dirty:Strategies for Ethnographic Research on Virtual Communities显示文摘 | Luciano Paccagnella | | 0，，01： | 1 |
| 12 | Adding gemcitabine to paclitaxel/carboplatin combination increases survival in advanced non-small-cell lung cancer:results of a phase II-III study显示文摘 | Paccagnella A Oniga F Bearz A | 2006 | J Clin Oncol2006，24，： | 1 |
| 13 | Extramedullary plasmacytoma: clinical behaviour and response to treatment 显示文摘 | Soesan M Paccagnella A Chiarion-Sileni V | 1992 | Ann Oncol1992，3，1： | 1 |
| 14 | Nutritional inter- vention for improving treatment tolerance in cancer pa- tients显示文摘 | Paccagnella A Morassutti I Rosti G | 2011 | Curr Opin Oncol2011，23，4： | 1 |
| 15 | Drain currtent decrease in MOSFETs after heavy ion irradiation 显示文摘 | Cester A Gerardin S Paccagnella A | 2004 | IEEE Trans Nuel Sei2004，51，6： | 1 |
| 16 | Nutritional intervention for improving treatment tolerance in cancer patients显示文摘 | Paccagnella A Morassutti I Rosti G | 2011 | Curr Opin Oncol2011，23，4： | 1 |
| 17 | Variabil- ity in FG memories performance after irradiation 显示文摘 | Cellere G Paccagnella A Visconti A | 2006 | IEEE Transactions on Nuclear Science2006，53，6： | 1 |
| 18 | Pre-operative chemotherapy in non-small cell lung cancer stage Ⅲ patients ,feasibility , toxicity and long-term results of a phase Ⅱ study显示文摘 | Favaretto A Paccagnella A Tomio L | 1996 | Europ J Cancer1996，32，12： | 1 |
| 19 | Early nutritional intervention improves treatment tolerance and outcomes in head and neck cancer patients undergoing concurrent chemoradiothera- py显示文摘 | Paccagnella A Morello M Da Mosto MC | 2010 | Support Care Cancer2010，18，7： | 1 |
| 20 | Early nutritional intervention improves treatment tolerance and outcomes in head and neck cancer patients undergoing concurrent chemoradiotherapy 显示文摘 | Paccagnella A Morello M Da Mosto M C | 2010 | Support Care Cancer2010，18，7： | 1 |
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