|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy显示文摘AIM To assess the outcomes of drug therapy(DT)followed by pancreatic endotherapy for continuing painful episodes in recurrent acute pancreatitis.METHODS DT comprised of pancreatic enzymes and antioxidants failing which,endotherapy(ET;pancreatic sphincterotomy and stent placement)was done.The frequency of pain,its visual analogue score(VAS),quality of life(Qo L),serum C peptide and faecal elastase were compared between baseline and after 1 year of follow up in all patients and in the two subgroups on DT and ET.Response was defined as at least 50%reduction in the severity of pain to below a score of 5.RESULTS Of the thirty nine patients analysed,21(53.9%)responded to DT and 18(46.1%)underwent ET.The VAS for pain(7.0±2.0 vs 1.3±2.5,P<0.001)and the number of days with pain per month decreased[1.0(1.0,2.0)vs 1.0(0.0,1.0),P<0.001],and the Qo L scores[55.0(44.0,66.0)vs 38.0(32.00,51.00),P<0.01]improved significantly during follow up.Similar significant improvements were seen in patients in the subgroups of DT and ET except for Qo L in ET.The serum C-peptide(P=0.001)and FE(P<0.001)levels improved significantly in the entire group and in the two subgroups of patients except for the C peptide levels in patients on DT.CONCLUSION A standardised protocol of DT,followed by ET decreased the intensity and frequency of pain in recurrent acute pancreatitis,enhanced Qo L and improved pancreatic function. | C Ganesh Pai M Ganesh Kamath Mamatha V Shetty Annamma Kurien | 2017 | World Journal of Gastroenterology2017，23，19： | 2 |
| 3 | Estrogen receptor-beta expression in human testicular germ cell tumors显示文摘 | Pais V Leav I Lau KM | 2003 | Clin Cancer Res2003，9，： | 1 |
| 4 | Pedunculated cribriform adenocarcinoma of the base of the tongue显示文摘 | Prasad K C Kaniyur V Pai R R | 2004 | Ear Nose Throat J2004，83，1： | 1 |
| 5 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 6 | Development of magnetic device for cell separation显示文摘 | Haik Y Pai V Che C J | 1999 | J Magn Magn Mater1999，194，123： | 1 |
| 7 | Influ- ence of growth parameters on the reactivity of ammonium perchlorate显示文摘 | Maycock J N Pai Verneker V R Rooch L | 1968 | Inorg Nucl Chem Lett1968，4，： | 1 |
| 8 | Gamma interferon release assays for detection of Mycobacterium tuberculosis in- fection显示文摘 | Pai M Claudia M D Sandra V K | 2014 | Clin Microbiol Rev2014，7，1： | 1 |
| 9 | Primary carcinoid tumor of the liver: report of four reseeted eases including one with gastrin production显示文摘 | Krishnamurthy SC Dutta V Pai SA | 1996 | J Surg Oneol1996，62，3： | 1 |
| 10 | Epidemiology and natural history of nonalcoholic fatty liver disease 显示文摘 | Pais R Ratziu V | 2012 | Rev Prat2012，62，10： | 1 |
| 11 | The epigynous glands of Zingiberaceae显示文摘 | Rao V S Pai R M | 1963 | New Phytol1963，62，： | 1 |
| 12 | Parallel Programmable Eth- ernet Controllers: Performance and Security 显示文摘 | Schuff D L Pai V S Willmann P | 2007 | Network IEEE2007，21，4： | 1 |
| 13 | An overview of nonalcoholic steatohepatitis:past,present and future directions显示文摘 | Pascale A Pais R Ratziu V | | 0，，04： | 1 |
| 14 | A Multicenter,Prospective,Randomized,Double-blind Study to Evaluate the Safety and Efficacy of Saroglitazar 2 and 4 mg Compared to Pioglitazone 45 mg in Diabetic Dyslipidemia(PRESS V)显示文摘 | Pai V Paneerselvam A Mukhopadhyay S | 2014 | J Diabetes Sci Technol2014，8，1： | 1 |
| 15 | Retrospective analysis of Steven- Johnson syndrome and toxic epidermal necrolysis over a period of 5 years from northern Karnataka, India显示文摘 | Naveen KN Pai VV Rai V | 2013 | Indian J Pharmacol2013，45，1： | 1 |
| 16 | Ectopic thymoma of the chest wall显示文摘 | Pai K R Thonse V R Azadeh B | 2005 | Interact Cardio Vasc Thorac Surg2005，4，1： | 1 |
| 17 | A new approach to thermochemical calculations of condensed fuel-oxidizer mixtures显示文摘 | JAIN S R ADIGA K C PAI VERNEKER V R | 1981 | Combus Flame1981，40，： | 1 |
| 18 | Minimally invasive plate fixation of the tibia显示文摘 | pai V Coulter G Pai V | 2007 | International Orthopaedics2007，31，4： | 1 |
| 19 | Predicting heats of formation of energetic materials using quantum chemical calculations显示文摘 | Rice B M Pai S V Hare J | 1999 | Combustion and Flame1999，118，44： | 1 |
| 20 | An overview of nonalcoholic steatohepatitis:past,present and future directions显示文摘 | Pascale A Pais R Ratziu V | 2010 | J Gastrointestin Liver Dis2010，19，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员