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| 1 | Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats显示文摘AIM: To evaluate the preventive effect of Ginkgo bilobaextract (GbE) on ethanol-induced gastric mucosal injuries in rats.METHODS: Female Wistar albino rats were used for the studies. We randomly divided the rats for each study into five subgroups: normal control, experimental control, and three experimental groups. The gastric ulcers were induced by instilling 1 mL 50% ethanol into the stomach. We gaveGbE 8.75, 17.5, 26.25 mg/kg intravenously to the experimental groups respectively 30 min prior to the ulcerative challenge. We removed the stomachs 45 min later. The gastric ulcers,gastric mucus and the content of non-protein sulfhydryl groups (NP-SH), malondialdehyde (MDA), c-Jun kinase (JNK) activity in gastric mucosa were evaluated. The amount of gastric juice and its acidity were also measured. RESULTS: The findings of our study are as follows: (1)GbE pretreatment was found to provide a dose-dependent protection against the ethanol-induced gastric ulcers in rats; (2) the GbE pretreatment afforded a dose-dependent inhibition of ethanol-induced depletion of stomach wall mucus, NP-SH oontents and increase in the lipid peroxidation (increase MDA) in gastric tissue; (3) gastric ulcer induced by ethanolproduced an increase in JNK activity in gastric mucosawhich also significantly inhibited by pretreatment with GbE;and (4) GbE alone had no inhibitory effect on gastric secretionin pylorus-ligated rats.CONCLUSION: The finding of this study showed that GbE significantly inhibited the ethanol-induced gastric lesions in rats. We suggest that the preventive effect of GbE may be mediated through: (1) inhibition of lipid peroxidation;(2) preservation of gastric mucus and NP-SH; and (3)blockade of cell apoptosis. | Sheng-Hsuan Chen Yu-Chih Liang Jane CJ Chao Li-Hsueh Tsai Chun-Chao Chang Chia-Chi Wang Shiann Pan | 2005 | World Journal of Gastroenterology2005，11，24： | 6 |
| 2 | Changes in microRNAs associated with hepatic stellate cell activation status iden- tify signaling pathways显示文摘 | Guo CJ Pan Q Cheng T | 2009 | FEBS J2009，276，18： | 1 |
| 3 | Neuroimaging and quality-of-life outcomes in patients with brain metastasis and peritumoral edema who undergo Gamma Knife surgery显示文摘 | Pan HC Sun MH Chen CC Chen CJ Lee CH Sheehan J | 2008 | J Neurosurg2008，，： | 1 |
| 4 | MiR -15b and miR -16 are inrvplicated in activation of the rat hepatic stellate cell: an essentialrole for apoptosis显示文摘 | GUO CJ PAN Q LI DG | 2009 | J Hepatol2009，50，4： | 1 |
| 5 | Multicenter,randomized, double-masked, parallel-group assessment of simultaneous glipizide/metformin as second-line pharmacologic treatment for patients with type 2 diabetes mellitus that is inadequately controlled by a sulfonylurea显示文摘 | Goldstein BG Pans M Rubin CJ | 2003 | Clin Ther2003，25，3： | 1 |
| 6 | Structure-function analysis of human glucose-6-phosphatase, the enzyme deficient in glycogen storage disease type la显示文摘 | Lei KJ Pan CJ Liu JL Shelly LL Chou JY | 1995 | J Biol Chem1995，270，11： | 1 |
| 7 | Curvilinear relations between age and hemostatic parameters in Chinese显示文摘 | Yeh CJ Pan WH Bai CH | 1994 | Thromb Haemost1994，72，2： | 1 |
| 8 | Multicenter,randomized,double-masked,parallel-group assessment of simultaneous glipizide/metformin as second-line pharmacologic treatment for patients with type 2 diabetes mellitus that is inadequately controlled by a sulfonylurea显示文摘 | Goldstein BJ Pans M Rubin CJ | | Clinical Therapeutics0，，： | 1 |
| 9 | Angiotensin mediates renalfibrosis in the nephropathy of glycogen storage disease type I a显示文摘 | Yiu WH Pan CJ Ruef RA | 2008 | Kidney Int2008，73，6： | 1 |
| 10 | The role of protein -bound uremic toxins on peripheral artery disease and vascular access failure in patients on hemodialysis 显示文摘 | Lin CJ Pan CF Liu HL | 2012 | Atherosclerosis2012，225，1： | 1 |
| 11 | miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell : An essential role for apop- tosis 显示文摘 | Guo CJ Pan Q Li DG | 2009 | J Hepatol2009，50，4： | 1 |
| 12 | Structure-function study ofthe glucose-6-phosphate transporter,an eukaryotic antiporterdeficient in glycogen storage disease type Ib显示文摘 | Pan CJ Chen SY Lee S Chou JY | 2009 | Mol Genet Metab2009，96，1： | 1 |
| 13 | Prediction of liver fibrosis in patients with chronic hepatitis B by serum markers显示文摘 | PAN JJ YANG CF CHU CJ | 2007 | Hepatogastroenterology2007，54，77： | 1 |
| 14 | Functional analysisof mutations in the glucose-6-phosphate transporter that causeglycogen storage disease type Ib显示文摘 | Chen SY Pan CJ Lee S Peng W Chou JY | 2008 | Mol Genet Metab2008，95，4： | 1 |
| 15 | The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib andIc显示文摘 | Chen SY Pan CJ Nandigama K Mansfield BC Ambudkar SV Chou JY | 2008 | FASEB J2008，22，7： | 1 |
| 16 | Isolation of the gene for murine glucose- 6-phosphatase, the enzyme deficient in glycogen storage disease type la显示文摘 | Shelly LL Lei KJ Pan CJ | 1993 | J Biol Chem1993，268，21： | 1 |
| 17 | Impaired neutrophil activity and increased susceptibility tobacterial infection in mice lacking glucose-6-phosphatase-beta显示文摘 | Cheung YY Kim SY Yiu WH Pan CJ Jun HS Ruef RA etal | 2007 | J Clin Invest2007，117，3： | 1 |
| 18 | Effects of ultrasound-guided radial artery catheterization: an updated meta-analysis显示文摘 | Gao YB Yah JH Gao FQ Pan L Wang XZ Lv CJ | 2015 | Am J Emerg Meal2015，33，1： | 1 |
| 19 | Incidence and predictors of isolated systolic hypertension and isolated diastolic' hypertension in Taiwen 显示文摘 | Yeh CJ Pan WH Jong YS | 2001 | J Formos Med Assoc2001，100，： | 1 |
| 20 | Relationship between hemostatic factors and known cardiovascular disease correlates in two suburban populations in Taiwan显示文摘 | Pan WH Yeh CJ Chan P | 1999 | J Formos Med Assoc1999，98，8： | 1 |
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