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| 1 | Efficacy and safety of Shaoyang Xibi decoction in patients with knee osteoarthritis:a multi-center,single-blind,randomized controlled trial显示文摘PURPOSE: To observe the efficacy and safety of Shaoyang Xibi decoction(SYXBD) in patients with knee osteoarthritis(KOA), and to verify that the theory of 'Shaoyang dominating bone' in Traditional Chinese Medicine(TCM) can be applied to KOA treatment.METHODS: Participants were randomly allocated to two groups: SYXBD(treatment group, n = 66)and Meloxicam(control group, n = 66). Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) and 36-Item Short Form Health Survey(SF-36) were used to assess efficacy before the treatment and 8 weeks after the treatment.RESULTS: Baseline data before the treatment between the two groups were similar. The WOMAC scores significantly decreased and the SF-36 scores significantly increased after 8-week treatment in both groups compared with before the treatment(P < 0.05). SYXBD significantly decreased pain scores(P < 0.001), physical function scores(P <0.001) and the total scores(P < 0.001) in WOMAC compared to Meloxicam. SYXBD significantly improved physical function(P = 0.021), bodily pain(P = 0.002) and general health(P = 0.014), with no significant difference in role emotional(P = 0.053),role physical(P = 0.517), vitality(P = 0.241), social function(P = 0.712) and mental health(P = 0.800)in SF-36 compared to Meloxicam. No adverse events were reported in the treatment group while13 adverse events happened in the control group during the study.CONCLUSION: SYXBD, prepared based on the theory of 'Shaoyang dominating bone', has a better curative efficay and safety in patients with KOA compared with Meloxicam. The TCM theory of 'Shaoyang dominating bone' may be useful in KOA treatment. | Si Yuhao Ma Yong Guo Yang Pan Yalan Zheng Suyang Xu Guihua Da Weiwei Xu Lili | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 11 |
| 2 | Potential chronic liver toxicity in rats orally administered an ethanol extract of Huangqin(Radix Scutellariae Baicalensis)显示文摘OBJECTIVE: To investigate the potential chronic liver toxicity of oral administration of ethanol extract of Huangqin(Radix Scutellariae Baicalensis)(SBE) in Wistar rats.METHODS: SBE was administered to rats by gavage for 26 weeks, at doses of 300, 1250, or 2500 mg·kg-1·d-1 respectively. The rats were euthanized at the end of 13 and 26 weeks daily oral dosing and following 4 weeks of recovery time. The changes of hematology, urinary, blood biochemistry and histomorphology were examined at each time point and focus on liver function and histological changes.RESULTS: When SBE at a dose of up to 2500 mgkg-1 d-1 was fed to male and female rats for 2··6 weeks, the liver tissue showed some inflammatory change that predominated by leukocyte infiltrationbut returned to normal after withdrawal. In addition, high-dose SBE treatment of 26 weeks in rats,glucose, electrolyte and lipid levels also have some changes. In addition, there are no other functional or organic lesions related to SBE treatment.CONCLUSIONS: Long-term and high-dose SBE may cause liver damage, however, the structural damage of the liver can be restored after the ethanol extract stopping. SBE will be well-tolerated for long-term use as a drug or health food, but in order to ensure drug safety, liver function, and serum glucose, electrolyte and lipid levels should be monitored when using SBE long term. | Yi Yan Zhao Yong Li Chunying Zhang Yushi Bin Yang Yuan Yalan Pan Chen Wang Lianmei Liang Aihua | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 1 |
| 3 | Peptide binding specificities of HLA-B*5701 and B*5801显示文摘Recently, genome wide association studies showed that there is a strong association between abacavir-induced serious, idio-syncratic, adverse drug reactions (ADRs) and human leukocyte antigen-B*5701 (HLA-B*5701). Studies also found that ab-acavir-induced ADRs were seldom observed in patients carrying the HLA-B*5801 subtype. HLA-B*5801 of the same sero type (B17) as B*5701 differs by only 4 amino acids from B*5701. It is believed that because of these sequence differences, HLA-B*5801 cannot bind the specific peptides which are required for HLA-B*5701 to stimulate the T cell immune response. Thus, the difference in peptide binding profiles between HLA-B*5701 and B*5801 is an important clue for exploring the mechanisms of abacavir-induced ADRs. VHSE (principal component score vector of hydrophobic, steric, and electronic properties), a set of amino acid structural descriptors, was employed to establish QSAR models of peptide-binding affinities of HLA-B*5701 and B*5801. Optimal linear SVM (support vector machine) models with high predictive capabilities were obtained for both B*5701 and B*5801. The R 2 (coefficient of determination), Q 2 (cross-validated R 2 ), and R PRE 2 (R 2 of test set) of two optimal models were 0.7530, 0.7037, 0.6153 (B*5701) and 0.6074, 0.5966, 0.5762 (B*5801), respectively. For B*5701 and B*5801, the mutations in positions 45 (MET-THR) and 46 (ALA-GLU) have little influence on the selection specificity of the P2 position of the bound peptide. However, the mutation in position 97 (VAL-ARG) greatly influences the selection specificity of the P7 position. HLA-B*5701 prefers the bulky and positively charged amino acids at the P7 position. In contrast, HLA-B*5801 prefers the non-polar hydrophobic amino acids at the P7 position while positively charged amino acids are unfavored. | ZHANG YaLan MEI Hu WANG Qing XlEJiangAn LV Juan PAN XianChao TAN Wen | 2012 | Science China(Life Sciences)2012，55，9： | 1 |
| 4 | Interpersonal coordination in schizophrenia:a concise update on paradigms,computations,and neuroimaging findings显示文摘Social function deficits are a ubiquitous manifestation of many psychiatric disorders including schizophrenia(Burns,2006;Green et al,2015;Schilbach,2016).Patients with schizophrenia(PSZ)exhibit a variety of abnormalities in social cognition related to social perception,facial emotion recognition,mentalization,and interpersonal coordination(Turetsky et al,2007;Schilbach,2016;Green et al,2019). | Yafeng Pan Yalan Wen Yajie Wang Leonhard Schilbach Ji Chen | 2023 | Psychoradiology2023，3，1： | 0 |
| 5 | CFD simulation on membrane distillation of NaCl solution显示文摘A computational fluid dynamics(CFD)simu-lation that coupled an established heat and mass transfer model was carried out for the air-gap membrane distillation(AGMD)of NaCl solution to predict mass and heat behaviors of the process.The effects of temperature and flowrate on fluxes were first simulated and compared with available experimental data to verify the approach.The profiles of temperature,temperature polarization factor,and mass flux adjacent to the tubular carbon membrane surface were then examined under different feed Reynolds number in the computational domain.Results show that the temperature polarization phenomena can be reduced,and mass flux can be enhanced with increase in the feed Reynolds number. | Zhaoguang XU Yanqiu PAN Yalan YU | 2009 | Frontiers of Chemical Science and Engineering2009，3，3： | 0 |
| 6 | Relationship between groundwater cadmium and vicinity resident urine cadmium levels in the non-ferrous metal smelting area,China显示文摘Cadmium(Cd)has received widespread attention owing to its persistent toxicity and non-degradability.Cd in the human body is mainly absorbed from the external environment and is usually assessed using urinary Cd.Hunan Province is the heartland of the Chinese non-ferrous mining area,where several serious Cd pollution events have occurred,including high levels of Cd in the urine of residents.However,the environmental factors influencing high urinary Cd levels(UCLs)in nearby residents remain unclear.Therefore,211 nearby residents’UCLs and the corresponding sociological characteristics from nine groundwater samples in this area were analyzed using statistical analysis models.Groundwater Cd concentration ranged from 0.02 to 1.15μg/L,aligning with class III of the national standard;the range of UCL of nearby residents was 0.37–36.60μg/L,exceeding the national guideline of 0–2.5μg/L.Groundwater Cd levels were positively correlated with the UCL(P<0.001,correlation coefficient 95%CI=9.68,R^(2)=0.06).In addition,sociological characteristics,such as smoking status and education level,also affect UCL.All results indicate that local governments should strengthen the prevention and abatement of groundwater Cd pollution.This study is the first to systematically evaluate the relationship between groundwater Cd and UCL using internal and external environmental exposure data.These findings provide essential bases for relevant departments to reduce Cd exposure in regions where the heavy metal industry is globally prevalent. | Yujie Pan Yalan Li Hongxia Peng Yiping Yang Min Zeng Yang Xie Yao Lu Hong Yuan | 2023 | Frontiers of Environmental Science & Engineering2023，17，5： | 0 |
| 7 | Integrative studies on three new freshwater Amphileptus species(Ciliophora,Pleurostomatida)discovered in northern China显示文摘The morphology and molecular phylogeny of freshwater pleurostomatid ciliates are insufficiently explored.In the present study,we investigated three new Amphileptus species discovered in Lake Weishan and its vicinity,northern China,using standard alpha-taxonomic methods.Amphileptus paracarchesi sp.nov.is characterized by a lateral fossa(groove)in the posterior body portion,four macronuclear nodules,contractile vacuoles distributed along the dorsal margin,and 4-6 left and 44-50 right somatic kineties.Amphileptus pilosus sp.nov.differs from congeners by having 4-14 macronuclear nodules,numerous contractile vacuoles scattered throughout the cytoplasm,and 22-31 left and 35-42 right somatic kineties.Amphileptus orientalis sp.nov.is characterized by two ellipsoidal macronuclear nodules,three ventral contractile vacuoles,and about four left and 31-35 right somatic kineties.Phylogenetic analyses of nuclear small subunit ribosomal DNA(SSU rDNA)sequences indicate that the family Amphileptidae might be monophyletic while the genus Amphileptus is paraphyletic,as Pseudoamphileptus macrostoma robustly groups with Amphileptus sp.Although deep phylogenetic relationships of amphileptids are poorly resolved,multiple well-delimited species groups are recognizable within the genus Amphileptus. | Gongaote Zhang Yalan Sheng Yujie Liu Xiao Cao Saleh AAl-Farraj Peter Vdacny Hongbo Pan | 2022 | Marine Life Science & Technology2022，4，4： | 0 |
| 8 | The micronuclear histone H3 clipping in the unicellular eukaryote Tetrahymena thermophila显示文摘Clipping of the histone H3 N-terminal tail has been implicated in multiple fundamental biological processes for a growing list of eukaryotes.H3 clipping,serving as an irreversible process to permanently remove some post-translational modifications(PTMs),may lead to noticeable changes in chromatin dynamics or gene expression.The eukaryotic model organism Tetrahymena thermophila is among the first few eukaryotes that exhibits H3 clipping activity,wherein the first six amino acids of H3 are cleaved off during vegetative growth.Clipping only occurs in the transcriptionally silent micronucleus of the binucleated T.thermophila,thus offering a unique opportunity to reveal the role of H3 clipping in epigenetic regulation.However,the physiological functions of the truncated H3 and its protease(s)for clipping remain elusive.Here,we review the major findings of H3 clipping in T.thermophila and highlight its association with histone modifications and cell cycle regulation.We also summarize the functions and mechanisms of H3 clipping in other eukaryotes,focusing on the high diversity in terms of protease families and cleavage sites.Finally,we predict several protease candidates in T.thermophila and provide insights for future studies. | Fan Wei Bo Pan Jinghan Diao Yuanyuan Wang Yalan Sheng Shan Gao | 2022 | Marine Life Science & Technology2022，4，4： | 0 |
| 9 | Toxicity study of ethanol extract from Oroxylumindicum(L.) Vent in rats显示文摘OBJECTIVE: To evaluate the safety of Oroxylumindicum(L.) Vent extract administered for 26 weeks in Wistar rats.METHODS: Oroxylumindicum(L.) Vent extract was administrated to male and female rats by gavage once daily at doses of 54, 225, and450 mg·kg-1·d-1.The rats were sacrificed after administration for13 weeks and 26 weeks. Part of the rats in each group were allowed to recover for 4 weeks after 26-week administration. Systematic examinations including haematology, urology, blood biochemistry and histomorphology were performed at the end of13, 26 weeks of administration and 4 weeks of recovery.RESULTS: No treatment related adverse effect shappened on rats' general status, body weight, food consumption, urinary index and histomorphologyexamination. Although during the administration,in some rats of extract's groups, the value of Red blood cell count(RBC), white blood cell counts(WBC), hemoglobin(HGB), haematocrit(HCT) and K iron were decreased, and biochemistry index,such as glucose(GLU), triglyceride(TG), alanine transaminase(ALT) and blood urea nitrogen(BUN)were increased, the above parameters were within the normal ranges and all returned to baseline after the drug stopping for 4 weeks.CONCLUSION: The administration of Oroxylumindicum(L.) Vent extractat levers up to 450 mg/kg(equals to 75 times of clinical dose) is well toleratedfor both genders without significant toxicity within the administration duration in this study. | Yi Yan Zhao Yong Li Chunying Zhang Yushi Bin Yang Yuan Yalan Wang Lianmei Pan Chen Liang Aihua | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 0 |
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