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| 1 | Long acting octreotide in the treatment of advanced hepatocellular cancer and overexpression of somatostatin receptors: Randomized placebo-controlled trial显示文摘AIM: To estimate if and to what extent long acting octreotide (LAR) improves survival and quality of life in patients with advanced hepatocellular carcinoma (HCC). METHODS: A total of 127 cirrhotics, stages A-B, due to chronic viral infections and with advanced HCC, were enrolled in the study. Scintigraphy with 111Indium labeled octreotide was performed in all cases. The patients with increased accumulation of radionuclear compound were randomized to receive either oral placebo only or octreotide/octreotide LAR only as follows: octreotide 0.5mg s.c. every 8 h for 6 wk, at the end of wk 4-8 octreotide LAR 20 mg i.m. and at the end of wk 12 and every 4 wk octreotide LAR 30mg i.m.. Follow-up was worked out monthly as well as the estimation of quality of life (QLQ-C30 questionnaire). Patients with negative somatostatin receptors (SSTR) detection were followed up in the same manner. RESULTS: Scintigraphy demonstrated SSTR in 61 patients. Thirty were randomized to receive only placebo and 31 only octreotide. A significantly higher survival time was observed for the octreotide group (49 ± 6 wk) as compared to the control group (28 ± 1 wk) and to the SSTR negative group (28 ± 2 wk), LR = 20.39, df = 2, P < 0.01. The octreotide group presented 68.5% lower hazard ratio [95% CI (47.4%-81.2%)]. During the f irst year, a 22%, 39% and 43% decrease in the QLQ-C30 score was observed in each group respectively.CONCLUSION: The proposed therapeutic approach has shown to improve the survival and quality of life in SSTR positive patients with advanced HCC. | D Dimitroulopoulos D Xinopoulos K Tsamakidis A Zisimopoulos E Andriotis D Panagiotakos A Fotopoulou C Chrysohoou A Bazinis D Daskalopoulou E Paraskevas | 2007 | World Journal of Gastroenterology2007，13，23： | 18 |
| 2 | Totally laparoscopic left hepatectomy using the Torsional Ultrasonic Scalpel显示文摘Minimal invasive techniques have allowed for major surgical advances.We report our initial experience of performing total laparoscopic left hepatectomy(segmentsⅡ-Ⅳ)with the Lotus(laparoscopic operation by torsional ultrasound)Ultrasonic Scalpel.The perioperative and postoperative courses of the young female patient were uneventful and she is in a good general condition without complaints 18 mo after surgery.To the best of our knowledge,this is the first total laparoscopic hemihepatectomy to be performed in Greece,as well as the first laparoscopic liver resection using Lotus shears. | Georgios C Sotiropoulos Paraskevas Stamopoulos Petros Charalampoudis Ernesto P Molmenti Athanasios Voutsarakis Gregory Kouraklis | 2013 | World Journal of Gastroenterology2013，19，35： | 5 |
| 3 | A eyclooxygenase-2 (COX- 2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectai carcino- ma cells expressing COX-2 protein: regulation of COX-2 by butyrate显示文摘 | Crew T E Elder D J Paraskeva C | 2000 | Carcinogenesis2000，21，： | 1 |
| 4 | Adsorption of atrazine on soils:Model study显示文摘 | KOVAIOS I D PARASKEVA C A KOUTSOUKOS P G | 2006 | Journal of Colloid and Interface Science2006，299，： | 1 |
| 5 | Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia显示文摘 | Kaidi A Williams AC Paraskeva C | 2007 | Nat Cell Biol2007，9，2： | 1 |
| 6 | BCL-2 expression in human colorectal adenomasand carcinomas显示文摘 | Moorghen M Hicks D Chapman M Paraskeva C | 1994 | Oncogene1994，9，11： | 1 |
| 7 | Membrane processing for olive mill wastewater fractionation 显示文摘 | Paraskeva C A Papadakis V G sarouchi E T | 2007 | Desalination2007，213，： | 1 |
| 8 | Thromboangiitis obliterans (Buerger's Disease ):Searching for a therapeutic strategy 显示文摘 | Paraskevas K Liapis C Briana D | 2007 | Angiology2007，58，1： | 1 |
| 9 | Interaction between be- ta-cate-ninand HIF-1 promotes cellular adaptation to hypoxia显示文摘 | Kaidi A Williams AC Paraskeva C | 2007 | Nat Cell Biol2007，9，2： | 1 |
| 10 | Assess- ment of a phytogenic feed additive effect on broiler growth performance, nutrient digestibility and caecal mi- croflora composition 显示文摘 | K C Mountzouris V Paraskevas P Tsirtsikos | 2011 | Animal Feed Science and Technology2011，168，3： | 1 |
| 11 | Membrane pro- cessing for olive mill wastewater fractionation 显示文摘 | Paraskeva C A Papadakis V G Tsarouchi E | 2007 | Desalination2007，213，： | 1 |
| 12 | 显示文摘 | Tsang S C Caps V Paraskevas I | 2004 | Angew Chem Int Ed2004，43，42： | 1 |
| 13 | Magnetically separable,carbon-supported nanocatalysts for the manufacture of fine chemicals显示文摘 | S C Tsang V Caps I Paraskevas | | 0，，42： | 1 |
| 14 | Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes coloreetal tumor cell survival and enhances HIF-1 transcriptional activity dining hypoxia 显示文摘 | Kaidi A Qualtrough D Williams AC Paraskeva C | 2006 | Cancer Res2006，66，13： | 1 |
| 15 | Impact of graded Hypothermia oncoagulation and flbrinolysis显示文摘 | Staikou C Paraskeva A Drakos E | 2011 | Surg Res2011，167，1： | 1 |
| 16 | Computational representation and hemodynamic characterization of in vivo ac- quired severe stenotic renal artery geometries using turbulence modeling 显示文摘 | Kagadis G C Skouras E D Bourantas G C Paraskeva C A Katsanos K Karnabatidis D Ni- kiforidis G C | 2008 | J Med Eng Phys2008，30，5： | 1 |
| 17 | Impact of graded hypothermia on coagulation and fibrinolysus显示文摘 | Staikou C Paraskeva A Drakos E | 2011 | J Surg Res2011，167，1： | 1 |
| 18 | Temperature dependent dielectric spectroscopy in frequency domain of high-voltage transfor- mer oils compared to physicochemical results显示文摘 | Paraskevas C D Vassiliou P Dervos C T | 2006 | IEEE Transactions on Dielectrics and Electrical Insulation2006，13，3： | 1 |
| 19 | Induced apoptosis in the prevention of colorectal cancer by non-steroidal anti-inflammatory drugs 显示文摘 | Elder D J Paraskeva C | 1999 | Apoptosis1999，4，5： | 1 |
| 20 | Interaction between beta- catenin and HIF-1 promotes cellular adaptation to hypoxia显示文摘 | Kaidi A Williams AC Paraskeva C | 2007 | Nat cell Biol2007，9，2： | 1 |
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