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	题名	作者	年代	出处	被引量
1	Genetic diversity of the hepatitis C virus: Impact and issues inthe antiviral therapy显示文摘The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review.	H Le Guillou-Guillemette S Vallet C Gaudy-Graffin C Payan A Pivert A Goudeau F Lunel-Fabiani	2007	World Journal of Gastroenterology2007，13，17：	6
2	Stability and structural analysis of α-amylase from the antarctic psychrophile Alteromonas haloplanctis A23显示文摘	Feller G Payan F Theys M	1994	Eur J Biochem1994，，222：	1
3	Stability and structural analysis of α-amylase from the Antarctic psychrophile Alteromonas haloplanctis A23显示文摘	Feller G Payan F Theys F	1994	European Journal of Biochemistry1994，222，：	1
4	Group connectivity of graphs-a nonhomogeneous analogue of nowhere-zero flow properties 显示文摘	JAEGER F LINIAL N PAYAN C	1992	J Combinatorial Theory:Ser B1992，56，：	1
5	High interaction alginate - hyaluronate associations by hyaluronate deacetylation for the preparation of effident biomaterials显示文摘	Oerther S Maurin A Payan E Hubert P I.apicque F Presle N etal		0，，：	1
6	An efficient bit allocation for compressing normal meshes with an error-driven quantization显示文摘	Payan F Antonini M	2005	Computer Aided Geometric Design2005，22，：	1
7	Stability and structural analysis of a-amylase from the Antarctic psychrophile Alteromonas haloplantbcs A23显示文摘	Feller G Payan F Theys F	1994	Eur J Biochem1994，222，2：	1
8	XIP-Ⅰ,a xylanase inhibitor protein from wheat:A novel protein function显示文摘	JUGE N PAYAN F WILLIAMSON G	2004	Biochimica and Biophysica Acta2004，1696，：	1
9	The dual nature of the wheat xylanase protein inhibitor XIP-Ⅰ:structural basis for the inhibition of family 10 and family 11 xylanases显示文摘	PAYAN F LEONE P PORCIERO S	2004	Journal of Biological Chemistry2004，279，36：	1
10	Stability and structural analysis of a-amylase from the Antarctic psychrophile Alteromonas haloplanctis A23 显示文摘	Feller G Payan F They F	1994	Eur J Biochem1994，222，：	1
11	Stability and structural analysis of α-amylase from the Antarctic Psychrophile Alteromonas haloplanctis A23显示文摘	Feller G Payan F Theys F	1994	Eur J Biochem1994，222，：	1
12	Carbonation assessment in concrete by nonlinear ultrasound 显示文摘	Bouchaala F Payan C Gamier V	2011	Cement and Concrete Research2011，41，：	1
13	Group connectivity of graphs-a nonhomogeneons analogue of nowhere-zero flow properties 显示文摘	Jaeger F Linial N Payan C	1992	Jounal of Combinatoral Theory Se- ries B1992，56，2：	1
14	Evaluation of the Ortho total HCV core antigen assay in comparison to methods of detection and quantification for HCV RNA显示文摘	Lunel F Veillon P Payan C	2002	Hepatology2002，36，2：	1
15	Group Connectivity of Graphs-a Nonhomogeneous Analogue of Nowhere Zero Flow Properties显示文摘	JAEGER F N LINIAL C PAYAN N TARSI	1992	J Combinatorial Theory Ser B1992，56，：	1
16	A linear programming approach to test efficiency in multiobjective linear fractional programming problems显示文摘	Lotfi F H Noora A A Jahanshahloo G R Khodabakhshi M Payan A	2010	Applied Mathematical Modelling2010，34，1：	1
17	Mutation analysis of ISDR and V3domains of hepatitis C virus NS5A region during interferon therapywith or without ribavirin显示文摘	Veillon P Payan C Lunel F	2003	Pathol Biol(Paris)2003，38，0：	1
18	Monitorating changes and predicting loss of ambulation in Duchenne muscular dystrophy with the motor function measure显示文摘	Vuillerot C Girardot F Payan C	2009	Dev Med Child Neurol2009，52，1：	1
19	Responsiveness of the motor function measure in neuromuscular diseases显示文摘	Vuillerot C Payan C Girardot F	2012	Arch PhysMed Rehabil2012，93，12：	1
20	Stability and structural analysis of α-amylase from the Antarctic psychrophile Alteromonas haloplanctis A23显示文摘	Feller G Payan F	1994	Eur J Biochem1994，222，：	1

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