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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study显示文摘AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer(rt HNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, video-fluoroscopic images of rt HNC patients(n = 21) were compared with age and gender matched controls(n = 21). Penetration-aspiration of the bolus and bolus residue were measured as swallowing outcome variables. Timing and displacement measurements of the anterior and posterior muscular slings elevating the hyolaryngeal complex were acquired. Coordinate data of anatomical landmarks mapping the action of the anterior muscles(suprahyoid muscles) and posterior muscles(long pharyngeal muscles) were used to calculate the distance measurements, and slice numbers were used to calculate time intervals. Canonical variate analysis with post-hoc discriminant function analysis was performed on coordinate data to determine multivariate mechanics of swallowing associated with treatment. Pharyngeal constriction ratio(PCR) was also measured to determine if weak pharyngeal constriction is associated with post radiation therapy.RESULTS: The rt HNC group was characterized by poor swallowing outcomes compared to the control group in regards to: Penetration-aspiration scale(P < 0.0001), normalized residue ratio scale(NRRS) for the valleculae(P = 0.002) and NRRS for the piriform sinuses(P = 0.003). Timing and distance measurements of the anterior muscular sling were not significantly different in the two groups, whereas for the PMS time of displacement was abbreviated(P = 0.002) and distance of excursion was reduced(P = 0.02) in the rt HNC group. A canonical variate analysis shows a significant reduction in pharyngeal mechanics in the rt HNC group(P < 0.0001). The PCR was significantly higher in the test group than the control group(P = 0.0001) indicating reduced efficiency in pharyngeal clearance. CONCLUSION: Using videofluoroscopy, this study shows rt HNC patients have worse swallowing outcomes associated with reduced hyolaryngeal mechanics and pharyngeal constriction compared with controls. | William G Pearson Jr Alisa A Davidoff Zachary M Smith Dorothy E Adams Susan E Langmore | 2016 | World Journal of Radiology2016，8，2： | 2 |
| 3 | Evidence for two rhabdoviruses in taro ( Colocasia esculenta) in the Pacific region显示文摘 | Pearson M N Jackson G V H Saelea J | 1999 | Austral Plant Pathol1999，28，3： | 2 |
| 4 | 显示文摘 | Parr R G Pearson R G | 1983 | J Am Chem Soc1983，105，： | 1 |
| 5 | Concrete penetration by eroding projectiles: experiments and analysis 显示文摘 | Gold V M Vrasis G C Pearson J C | 1996 | Journal of Engineering Mechanics1996，122，2： | 1 |
| 6 | -MSH inhibits inflammatory signaling in Schwann cells显示文摘 | Teare Katrina A Pearson Richard G Shakesheff Kevin M | 2004 | NeuroReport2004，15，3： | 1 |
| 7 | Tissue culture of the enteric nervous system from equine Ileum 显示文摘 | Hudson N P H Pearson G T Mayhew I G | 2000 | Veterinary Research Communications2000，24，： | 1 |
| 8 | Paediatric index of mortality (PIM) : a mortality prediction model for children in intensive care 显示文摘 | Shann F Pearson G Slater A | 1997 | Intens Care Med1997，23，2： | 1 |
| 9 | Metabolic relations to temperatures in the copepods Diaptomus dorsalis and Mesocyclopes edax from North-Central Texas显示文摘 | Smith G A Fitzpatrick L C Pearson W D | | 0，，： | 1 |
| 10 | Predicting species distributions from small numbers of occurrence re- cords:A test case using cryptic geckos in Madagascar 显示文摘 | Pearson R G Raxworthy C J Nakamura M | 2007 | Journal of Biogeography2007，34，1： | 1 |
| 11 | 显示文摘 | Pearson R G | 1995 | Inorg Chim Acta1995，240，： | 1 |
| 12 | New insights into the control of MAP kinase pathways 显示文摘 | English J Pearson G Wilsbacher J | 1999 | Exp Cell Res1999，253，1： | 1 |
| 13 | Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association 显示文摘 | Pearson T A Mensah G A Alexander R W | 2003 | Circulation2003，107，3： | 1 |
| 14 | The involvement of cell-to-cell signals in the development of a bacterial biofilm显示文摘 | DAVIES D G PARSEK M R PEARSON J P | 1998 | Science1998，280，5361： | 1 |
| 15 | Molecular signatures in biopsy specimens of lung cancer显示文摘 | Borczuk A C Shah L Pearson G D | 2004 | Am J Respir Crit Care Med2004，170，2： | 1 |
| 16 | Absolute hardness:Companion parameter to absolute electronegativity显示文摘 | Parr R G Pearson R G | 1983 | J Am Chem Soc1983，105，26： | 1 |
| 17 | The state of pediatric interfacility transport: consensus of the second National Pediatric and Neonatal Interfacility Transport Medicine Leadership Conference 显示文摘 | Woodward G A Insoft R M Pearson Shaver A L | 2002 | Pediatr E- merg Care2002，18，1： | 1 |
| 18 | Solvent extraction/anion exchange separation and determination of PGEs(Os,Ir,Pt,Pd,Ru)and Re-Os isotopes in geological samples by isotope dilution ICP-MS显示文摘 | Pearson D G Woodland S J | | 0，，1： | 1 |
| 19 | The Prediction of Teaching Autonomy显示文摘 | Pearson L G | 1998 | Educational Research Quarterly1998，，1： | 1 |
| 20 | Mitogen-activated protein (MAP) kinase pathway:regulation and physiological funcdons显示文摘 | Pearson G Robinson F Beers Gibson T | 2001 | Endocr Rev2001，22，： | 1 |
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