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| 1 | Artificial intelligence in the diagnosis and management of colorectal cancer liver metastases显示文摘Colorectal cancer(CRC)is the third most common malignancy worldwide,with approximately 50%of patients developing colorectal cancer liver metastasis(CRLM)during the follow-up period.Management of CRLM is best achieved via a multidisciplinary approach and the diagnostic and therapeutic decision-making process is complex.In order to optimize patients’survival and quality of life,there are several unsolved challenges which must be overcome.These primarily include a timely diagnosis and the identification of reliable prognostic factors.Furthermore,to allow optimal treatment options,a precision-medicine,personalized approach is required.The widespread digitalization of healthcare generates a vast amount of data and together with accessible high-performance computing,artificial intelligence(AI)technologies can be applied.By increasing diagnostic accuracy,reducing timings and costs,the application of AI could help mitigate the current shortcomings in CRLM management.In this review we explore the available evidence of the possible role of AI in all phases of the CRLM natural history.Radiomics analysis and convolutional neural networks(CNN)which combine computed tomography(CT)images with clinical data have been developed to predict CRLM development in CRC patients.AI models have also proven themselves to perform similarly or better than expert radiologists in detecting CRLM on CT and magnetic resonance scans or identifying them from the noninvasive analysis of patients’exhaled air.The application of AI and machine learning(ML)in diagnosing CRLM has also been extended to histopathological examination in order to rapidly and accurately identify CRLM tissue and its different histopathological growth patterns.ML and CNN have shown good accuracy in predicting response to chemotherapy,early local tumor progression after ablation treatment,and patient survival after surgical treatment or chemotherapy.Despite the initial enthusiasm and the accumulating evidence,AI technologies’role in healthcare and CRLM management is not yet fully established.Its limitations mainly concern safety and the lack of regulation and ethical considerations.AI is unlikely to fully replace any human role but could be actively integrated to facilitate physicians in their everyday practice.Moving towards a personalized and evidence-based patient approach and management,further larger,prospective and rigorous studies evaluating AI technologies in patients at risk or affected by CRLM are needed. | Gianluca Rompianesi Francesca Pegoraro Carlo DL Ceresa Roberto Montalti Roberto Ivan Troisi | 2022 | World Journal of Gastroenterology2022，28，1： | 5 |
| 2 | Chemical modification of carbon fiber surfaces显示文摘 | Febo Severini Leonardo Formaro Mario Pegoraro Luca Posca | 2002 | Carbon2002，，5： | 2 |
| 3 | Relativistic laser-matter interaction and relativistic laboratoryastrophysics显示文摘 | S. V. Bulanov T. Zh. Esirkepov D. Habs F. Pegoraro T. Tajima | 2009 | The European Physical Journal D2009，，2： | 2 |
| 4 | An analytical solution to single scattering in homogeneous participating media 显示文摘 | Pegoraro V Parker S G | 2009 | Computer Graphics Forum2009，28，2： | 1 |
| 5 | Annual variation in soil respiration and its components in a coppice oak forest in Central Italy显示文摘 | Rey A Pegoraro E Tedeschi V | 2002 | Global Change Biology2002，8，： | 1 |
| 6 | Methylenetetrahydrofolate reductase gene polymorphisms in black South Africans and the association with preeclampsia显示文摘 | Pegoraro RJ Chikosi A Rom L | 2004 | Acta Obstet Gynecol Scand2004，83，5： | 1 |
| 7 | Coagulation gene polymorphisms as risk factors for myocardial infarction in young Indian Asians显示文摘 | Pegoraro R J Ranjith N Rom L | 2005 | Cardiovasc J S Afr2005，16，3： | 1 |
| 8 | Annual variation in soil respiration and its components in a coppice oak forest in Central Italy显示文摘 | Rey A Pegoraro E Tedeschi V | 2002 | Global Change Biology2002，8，9： | 1 |
| 9 | Chemical modification of carbon fiber surfaces显示文摘 | Febo Severini Leonardo Formaro Mario Pegoraro | 2002 | Carbon2002，40，5： | 1 |
| 10 | Adiponectin gene polymorphism is selectively associated with the concomitant presence of metabolic syndromeand essential hypertension显示文摘 | Ranjith N Pegoraro RJ Shanmugam R | 2011 | PLoSOne2011，6，19： | 1 |
| 11 | Fracture strength of teeth with flared root canals restored with glass fibre posts显示文摘 | Bonfante G Kaizer OB Pegoraro LF | 2007 | Int Dent J2007，57，3： | 1 |
| 12 | Species identification by means of the eytochrome b gene显示文摘 | PARSON W K PEGORARO H NIEDERSTATFER M | 2000 | Int J Legal Med2000，114，： | 1 |
| 13 | Grafting reaction of methylmethacrylate onto EPR and EPDM rubbers toughening effects of graft copolymers on polycarbonate and poly (methyl methacrylate) 显示文摘 | Severini F Pegoraro M Landro L D | 1991 | Angewandte Makro- molekulare Chemie1991，190，： | 1 |
| 14 | Low-flow anaesthesia systems,charcoal and isoflurane kinetics显示文摘 | Romano E Pegoraro M Vacri A | 1992 | Anaesthesia1992，47，12： | 1 |
| 15 | Animal clks: a multitude of molecular mechanisms for circadian timekeeping显示文摘 | Pegoraro M Tauber E | 2011 | Wiley Interdiscip Rev RNA2011，2，2： | 1 |
| 16 | Living nearmajor traffic roads and risk of deep vein thrombosis 显示文摘 | BACCARELLI A MARTINELLII PEGORARO V | 2009 | Circulation2009，119，24： | 1 |
| 17 | Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation显示文摘 | Tarantini Letizia Bonzini Matteo Apostoli Pietro Pegoraro Valeria Bollati Valentina Marinelli Barbara Cantone Laura Rizzo Giovanna Hou Lifang Schwartz Joel Bertazzi Pier Alberto Baccarelli Andrea | 2009 | Environmental Health Perspectives2009，，： | 1 |
| 18 | Prognostic value of N-terminal-pro-brain natriuretic peptide measurements in patients with acute coronary syndromes 显示文摘 | Ranjith N Pegoraro RJ Naidoo DP | 2006 | Cardiovasc J S Aft2006，17，2： | 1 |
| 19 | Damping of electromagnetic waves due to electron-positron pair production显示文摘 | Bulanov S S Fedotov A M Pegoraro F | 2005 | Phys Rev E2005，71，01： | 1 |
| 20 | Species identificationby means of the cytochrome B gene 显示文摘 | Parson W Pegoraro K Niederstatter H | 2000 | Int Legal Med2000，114，： | 1 |
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