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| 1 | Moro orange juice prevents fatty liver in mice显示文摘AIM:To establish if the juice of Moro,an anthocyaninrich orange,may improve liver damage in mice with diet-induced obesity.METHODS:Eight-week-old mice were fed a high-fat diet(HFD) and were administrated water or Moro juice for 12 wk.Liver morphology,gene expression of lipid transcription factors,and metabolic enzymes were assessed.RESULTS:Mice fed HFD displayed increased body weight,insulin resistance and dyslipidemia.Moro juice administration limited body weight gain,enhanced insulin sensitivity,and decreased serum triglycerides and total cholesterol.Mice fed HFD showed liver steatosis associated with ballooning.Dietary Moro juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase,a key enzyme of lipid oxidation.Consistently,Moro juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase,and restored liver glycerol-3-phosphate acyltransferase 1 activity.CONCLUSION:Moro juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver. | Federico Salamone Giovanni Li Volti Lucilla Titta Lidia Puzzo Ignazio Barbagallo Francesco La Delia Shira Zelber-Sagi Michele Malaguarnera Pier Giuseppe Pelicci Marco Giorgio Fabio Galvano | 2012 | World Journal of Gastroenterology2012，18，29： | 2 |
| 2 | Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer显示文摘 | MINUCCI S PELICCI P G | 2006 | Nat Rev Cancer2006，6，1： | 1 |
| 3 | Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer 显示文摘 | Minucci S Pelicci PG | 2006 | Nat Rev Cancer2006，6，1： | 1 |
| 4 | Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66shc Gene显示文摘 | Marcello Rota Nicole LeCapitaine Toru Hosoda Alessandro Boni Antonella De Angelis Maria Elena Padin-Iruegas Grazia Esposito Serena Vitale Konrad Urbanek Claudia Casarsa Marco Giorgio Thomas F. Lüscher Pier Giuseppe Pelicci Piero Anversa Annarosa Leri Jan | 2006 | Circulation Research2006，，1： | 1 |
| 5 | A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction显示文摘 | Pelicci G Lanfrancone L Grignani F | 1992 | Cell1992，70，1： | 1 |
| 6 | A family of Shc related proteins with conserved PTB,CH1 and SH2 regions显示文摘 | Pelicci G Dente L De Giuseppe A | 1996 | Oncogene1996，13，3： | 1 |
| 7 | Constitutive degradation of the PML-RARαprotein is present in retinoic acid (RA)2resistant acute promyelocytic leukemia cells and involves the proteasome proteolytic pathway显示文摘 | Fanelli M Nervi C Pelicci P G | 1997 | Blood1997，190，： | 1 |
| 8 | Constitutive phosphorylation of Shc proteins in human tumors显示文摘 | Pelicci G Lanfrancone L Salcini AE | 1995 | Oncogene1995，11，5： | 1 |
| 9 | Histone deacetylase inhibitors and the promise of epigenetic(and more)treatments for cancer显示文摘 | Minucci S Pelicci PG | 2006 | Nat Rev Cancer2006，6，1： | 1 |
| 10 | Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer显示文摘 | Minucci S Pelicci P G | 2006 | Nat Rev Cancer2006，6，1： | 1 |
| 11 | Histone deacetylase inhibitors and the promise of epigenetic ( and more) treatments for cancer 显示文摘 | Minucci S Pelicci PG | 2006 | Nat Rev Cancer2006，6，： | 1 |
| 12 | Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer 显示文摘 | Minucci S Pelicci PG | 2006 | Nat Rev Cancer2006，6，： | 1 |
| 13 | Myeloid and megakaryocytic properties of K562 cell lines 显示文摘 | Tabilio A Pelicci PG Vinci G | 1983 | Cancer Res1983，43，10： | 1 |
| 14 | The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway 显示文摘 | Pelicci G Troglio F Bodini A | 2002 | Mol Cell Biol2002，22，20： | 1 |
| 15 | Nol all Shc's roads lead to Ras 显示文摘 | Bonfini L Migliaccio E Pelicci G | 1996 | Trends Biochem Sci1996，21，7： | 1 |
| 16 | Histone deacetylase inhibitors and the promise of epigenetic ( and more) treatments for cancer 显示文摘 | MINUCCI S PELICCI P G | 2006 | Nat Rev Cancer2006，6，1： | 1 |
| 17 | Histone deacetylase inhibitors and the promise of epigenetic( and more) treatments for cancer 显示文摘 | Minucci S Pelicci P G | 2006 | Nat Rev Cancer2006，6，1： | 1 |
| 18 | Thyroid function tests in patients undergoing maintenance dialysis:characterization of the'low T4 syndrome' in subjects on regular hemodialysis and continuous ambulatory peritoneal dialysis显示文摘 | Pagliacci MC Pelicci G Grignani F | 1987 | Nephron1987，46，3： | 1 |
| 19 | Tumour-associated hypermethylation: silencing E-cadherin expression enhances invasion and metastasis显示文摘 | DICROCE L PELICCI P G | 2003 | Eur J Cancer2003，39，4： | 1 |
| 20 | Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for caneer显示文摘 | Minucci S Pelicci PG | 2006 | Nat Rev Cancer2006，6，1： | 1 |
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