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| 1 | Light-induced protein translocation by genetically encoded unnatural amino acid in Caenorhabditis elegans显示文摘Dear Editor,Living systems such as Caenorhabditis elegans are organized by interaction networks of biopolymer and small mol-ecules.The molecular engineering of specifi c targets to monitor and control these biological molecules has led to significant advances in our understand-ing of how biological systems are organ-ized,maintain themselves and disin-tegrate(Prescher and Bertozzi,2005).For instance,green fl uorescent protein(GFP)derived from jellyfi sh Aequorea Victoria helps us to accurately locate and observe proteins over long term periods.In addition,many novel LOV(light,oxy-gen,or voltage)domains such as LOV2-Jαand Vivid offer the possibility of cell-based motility management and tissue-based gene expression control(Wu et al.,2009;Wang et al.,2012). | Hao Chang Mei Han Wenming Huang Guifeng Wei Juanjuan Chen Peng R.Chen Runsheng Chen Junlong Zhang Tao Xu Pingyong Xu | 2013 | Protein & Cell2013，4，12： | 2 |
| 2 | Bioorthogonal chemistry in living animals显示文摘Bioorthogonal chemistry refers to those chemical reactions that can be performed in living systems without interfering with native biological processes.Since its first introduction by Bertozzi et al.in | Xinyuan Fan Jie Li Peng R.Chen | 2017 | National Science Review2017，4，3： | 2 |
| 3 | Deciphering life sciences with“live”chemistry——The 2022 Nobel Prize in Chemistry显示文摘The 2022 Nobel Prize in Chemistry was awarded to Carolyn R.Bertozzi,Morten Meldal andK.Barry Sharpless for their development of click reaction and bioorthogonal chemistry.Our understanding of life sciences has been fundamentally accelerated by such novel chemistries,and to some extent,revolutionized by the emergence of new chemical tools benefited from these cutting-edge interdisciplinary explorations.In turn,the high demands of more powerful chemical tools for the sophisticated living systems have further promoted the development of new chemistry with newfunctionalities and applications. | Xinyuan Fan Peng R.Chen | 2023 | Science China Chemistry2023，66，1： | 1 |
| 4 | Bioorthogonal Prodrug–Antibody Conjugates for On-Target and On-Demand Chemotherapy显示文摘Current antibody–drug conjugates(ADCs)suffer from low tissue penetration and significant side effects,largely due to the permanent linkage and/or premature release of cytotoxic payloads.Herein,we developed a prodrug–antibody conjugate(ProADC)strategy by conjugating a bioorthogonal-activatable prodrug with an antibody that allowed on-target release and on-demand activation of cytotoxic drugs at a tumor site.The bioorthogonal-caged prodrug exhibited an enhanced permeability into and on-demand activation within cancer cells,while the pH-sensitive ADC linker allowed on-target release of the anticancer agent.Together,the ProADCs showed enhanced tumor penetration and alleviated side effects for use as an on-target and on-demand chemotherapy agents. | Feng Lin Long Chen Heng Zhang William Shu Ching Ngai Xiangmei Zeng Jian Lin Peng R.Chen | 2019 | CCS Chemistry2019，1，2： | 0 |
| 5 | The role of inflammation in cerebral aneurysms显示文摘The natural history of unruptured intracranial aneurysms(IAs)is poorly understood.At present,risk factors for aneurysm rupture are limited to demographics and rudimentary anatomic features of the aneurysm.The first sign of aneurysm destabilization and rupture may be subarachnoid hemorrhage,a potentially devastating brain injury with high morbidity and mortality.An emerging body of literature suggests a complex inflammatory cascade likely promotes aneurysm wall remodeling and progressive ballooning of the arterial wall,ultimately terminating in aneurysm rupture.These events likely begin with hemodynamic,flow‑related endothelial injury;the injured endothelium stimulates inflammation,including the recruitment and transmigration of inflammatory cells,particularly macrophages.Various proteases are secreted by the inflammatory infiltrate,resulting in degradation of the extracellular matrix and the structural changes unique to IAs.Detailed understanding of these inflammatory processes may result in(1)early identification of patients at high risk for aneurysm rupture,perhaps via arterial wall imaging,and(2)targeted,noninvasive therapies to treat or even prevent cerebral aneurysms. | Ali H.Turkmani Nancy J.Edwards Peng R.Chen | 2015 | Neuroimmunology and Neuroinflammation2015，2，1： | 0 |
| 6 | Proximity Chemistry in Living Systems显示文摘Enzyme-and catalyst-generated reactive species have been leveraged in the past decade to covalently label biomolecules within a short range of a defined site or space inside cells or at the cell–cell interface.Due to their high spatial resolution,such proximity labeling strategies have been coupled with various bioanalytical techniques for dissecting dynamic and complex biological processes.Here,we review the development of enzyme-and catalyst-triggered proximity chemistry and their applications to identifying protein interaction networks as well as cell–cell communications in living systems. | Yanjun Liu Yun Ge Ruxin Zeng William Shu Ching Ngai Xinyuan Fan Peng R.Chen | 2023 | CCS Chemistry2023，5，4： | 0 |
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