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| 1 | Cytokine gene polymorphisms and graft-versus-host disease in children after matched sibling hematopoietic stem cell transplantation:a single-center experience显示文摘Various polymorphisms in cytokine genes have recently been investigated as candidate risk factors in allogeneic hematopoetic stem cell transplantation(allo-HSCT).We retrospectively analyzed specific polymorphisms in genes for interleukin(IL)-10,IL-6,tumor-necrosis factor alpha(TNF-α)and interferon gamma(IFN-c)in a pediatric cohort of 57 histocompatibility leucocyte antigen(HLA)-identical sibling myeloablative transplants.Both recipient and donor genotypes were tested for association with graft-versus-host disease(GVHD)by statistical methods including Cox regression analysis.We found a significant association between the IL-10 promoter haplotype polymorphisms at positions-1082,-819 and-592 with the occurrence of severe(grades Ⅲ–Ⅳ)acute GVHD(aGVHD).Recipients with the haplotype GCC had a statistically significant decreased risk of severe aGVHD(hazard risk(HR)50.20,95% confidence interval(CI):0.06–0.67)in comparison with patients with other IL-10 haplotypes(P50.008).Transplant-related mortality at 1 year was significantly lower in recipients with this haplotype(HR50.17,95% CI:0.012–0.320)versus other IL-10 haplotypes(P=0.03),whereas overall survival was not influenced by IL-10 haplotype polymorphisms.In multivariate analysis,the presence of the IL-10 GCC haplotype was found as the only variable associated with a statistically significant decreased hazard of severe aGVHD development(P=0.02,HR50.21,95% CI:0.05–0.78).These results suggest that pediatric patients possessing the IL-10 GCC haplotype may be protected from the occurrence of severe aGVHD in the setting of matched sibling HSCT. | Evgenios Goussetis Ioanna Varela Ioulia Peristeri Vasiliki Kitra Kleopatra Spanou Olga Moraloglou Anna Paisiou Sofia Karatasaki Alexandra Soldatou Nikki Constantinidou Stelios Graphakos | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 2 | Transverse testicular ectopia:three additional eases and a review of the literature显示文摘 | Naji H Peristeris A Stenman J | 2012 | Pediatr Surg Int2012，28，7： | 1 |
| 3 | Successful long- termimmunologic reconstitution by allogeneic hematopoietic stemcell transplantation cures patients with autosomal dominanthyper-IgE syndrome 显示文摘 | Goussetis E Peristeri I Kitra V | 2010 | J Allergy Clin Immunol2010，126，2： | 1 |
| 4 | Successful hematopoietic stem cell transplantation in 2 children with X- linked chronic granulomatous disease from their unaffected HLA- identical siblings selected using preimplantation genetic diagnosis combined with HLA typing 显示文摘 | Goussetis E Konialis CP Peristeri I | 2010 | Biol Blood Marrow Transplant2010，16，3： | 1 |
| 5 | Transverse testicular ectopia: three additional cases and a review of the literature 显示文摘 | Naji H Peristeris A Stenman J | 2012 | Pediatr Surg Int2012，28，7： | 1 |
| 6 | Combined umbilical cord blood and bone marrow transplantation in the treatment of beta-tbalassemia major显示文摘 | Goussetis E Peristeri J Kitra V Kattamis A Petropoulos D Papassotiriou I | 2000 | Pediatr Hematol Oncol2000，17，4： | 1 |
| 7 | Successful long-term immunologic reconstitution by allogeneic hematopoietic stem cell transplantation cures patients with autosomal dominant hyper-IgE syndrome显示文摘 | Goussetis E Peristeri I Kitra V | | 0，，： | 1 |
| 8 | Radiological simultaneous portohepatic vein embolization(RASPE)and major hepatectomy with hepatocellular carcinoma(HCC)显示文摘Radiological simultaneous portohepatic vein embolization(RASPE)is a relatively new technique,which aims to rapidly increase the future liver remnant(FLR)in patients with very small FLR in order to undergo major hepatectomy. | Georgios K.Glantzounis Anastasia Karampa Dimitra Peristeri | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 0 |
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