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| 1 | Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication,metabolite traits,and antiinflammatory effects显示文摘Foxtail millet(Setaria italica),which was domesticatedfromthewild speciesgreenfoxtail(Setaria viridis),isa richsource of phytonutrientsfor humans.To evaluate how breeding changed themetabolome offoxtail millet grains,we generated and analyzed the datasets encompassing the genomes,transcriptomes,metabolomes,and anti-inflammatory indices from 398 foxtail millet accessions.We identified hundreds of common variants that influence numerous secondary metabolites.We observed tremendous differences in natural variations of the metabolites and their underlying genetic architectures between distinct sub-groups of foxtail millet.Furthermore,we found that the selection of the gene alleles associated with yellow grains led to altered profiles of metabolites such as carotenoids and endogenous phytohormones.Using CRiSPR-mediated genome editing wevalidated the function of PHYTOENE SYNTHASE1(PSY1)gene in affecting milletgrain colorand quality.Interestingly,our in vitro cell inflammation assays showed that 83 metabolites in millet grains have anti-inflammatory effects.Taken together,ourmulti-omics study illustrates how the breeding history of foxtail millet has shaped its metabolite profile.The datasets we generated in this study also provide important resources for further understanding how millet grain quality is affected by different metabolites,laying the foundations for future millet genetic research and metabolome-assisted improvement. | Xukai Li Jianhua Gao Jingyi Song Kai Guo Siyu Hou Xingchun Wang Qiang He Yanyan Zhang Yakun Zhang Yulu Yang Jiaoyan Tang Hailang Wang Staffan Persson Mingquan Huang Lishuai Xu Linlin Zhong Dongqin Li Yongming Liu Hua Wu Xianmin Diao Peng Chen Xiaowen Wang Yuanhuai Han | 2022 | Molecular Plant2022，15，8： | 8 |
| 2 | Poisoning severity score,grading of acute poisoning 显示文摘 | Persson HE Sjoberg GK Haines JA | 1998 | Toxieol Clin Toxicol1998，36，3： | 1 |
| 3 | Poisoning severity score:Grading of acute poisoning显示文摘 | Persson HE Sjoberg GK Haines JA | 1998 | Toxicol Clin Toxicol1998，36，2： | 1 |
| 4 | Neurologic and neuropathologic outcome after middle cerebral artery occulusion in rats 显示文摘 | Persson L Hardemark He Bolander He | 1989 | Stroke1989，20，5： | 1 |
| 5 | Poisoning severity score grading cf acute poison显示文摘 | Persson HE Sjoberg CK Haines JA | 1998 | Toxicol Clin Toxicol1998，36，： | 1 |
| 6 | Prognosis in myocardial infarc- tion patients with heart failure and normal or mildly impaired sys- tolic function 显示文摘 | Jamert C Edner M Persson HE | 2007 | Int J Cardio12007，117，： | 1 |
| 7 | Visual evoked responses to pattern-reversal stimulation in childhood amblyopia显示文摘 | Wanger P Persson HE | 1980 | Acta Ophthalmol1980，55，5： | 1 |
| 8 | Poisoning severity score Grading of acute Poisoning 显示文摘 | Persson HE Sjoberg GK Haines JA | 1998 | Toxicol Clin Toxicol1998，36，3： | 1 |
| 9 | Visual evoked responses to pattern-reversal stimulation in childhood amblyopia显示文摘 | Wanger P Persson HE | 1980 | Acta Ophthalmol1980，58，5： | 1 |
| 10 | Prognosis in myocardial infarc-tion patients with heart failure and normal or mildly impaired systol-ic function显示文摘 | Jarnert C Edner M Persson HE | 2007 | Int J Cardiol2007，17，1： | 1 |
| 11 | Somatosensory testing in idiopathic scoliosis 显示文摘 | Odergren T Persson HE | 2002 | Dev Med Child Neurol2002，44，： | 1 |
| 12 | Somatosensory testing in idiopathic scoliosis显示文摘 | Olafsson Y Odergren T Persson HE | 2002 | Dev Med Child Neurol2002，44，2： | 1 |
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