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| 1 | Association of time to prostate-specific antigen nadir and logarithm of prostate-specific antigen velocity after progression in metastatic prostate cancer with prior primary androgen deprivation therapy显示文摘我们与优先的主要雄激素剥夺治疗(ADT ) 在变形前列腺癌症在前进木头(PSAVAP ) 以后调查了前列腺特定的抗原天底(TTPN ) 和前列腺特定的抗原速度的对数的时间的协会。从 2000 ~ 2009 与主要 ADT 对待的所有变形前列腺癌症病人被考察。开发了疾病前进的病人在随后的分析被包括。病人们根据他们的 TTPN 被分成三个组:< 的 TTPN; 3 个月, 3-17 月,和 > 17 个月。我们用 Mann-Whitney U-test 和 Kruskal-Wallis 测试比较了在不同 TTPN 组之间的木头(PSAVAP ) 。木头(PSAVAP ) 上的进一步多重的线性回归分析被执行为使因素惊讶的另外的潜力调整。在与主要 ADT 被对待的 419 个病人之中, 306 个病人与 28 个月的中部的后续开发了疾病前进。更长的 TTPN 与更低的木头(PSAVAP ) 被联系(P = 0.008 ) 在所有亚群分析以内(< 的 TTPN; 3 对 3-17 月, P = 0.020;3-17 对 > 的 TTPN; 17 个月, P = 0.009;并且 < 的 TTPN; 3 对 > 17 个月, P = 0.001 ) 。在多重线性回归分析之上,基线 PSA (回归系数 0.001 , P = 0.045 ), PSA 天底(回归系数 0.002 , P = 0.040 ),并且 TTPN (回归系数 − ; 0.030 , P = 0.001 )是显著地与木头( PSAVAP )被联系的三个因素。在结论,更长的 TTPN 在跟随主要 ADT 的变形前列腺癌症病人与更低的木头(PSAVAP ) 被联系。在 3 个月和 17 个月的 TTPN cut-offs 看起来在预言木头(PSAVAP ) 有预示的意义。TTPN 可以在与疾病前进在病人决定治疗策略用作好预示的指示物。 | Jeremy YC Teoh James HL Tsu Steffi KK Yuen Peter KF Chiu Samson YS Chan Ka-Wing Wong Kwan-Lun Ho Simon SM Hou Chi-Fai Ng Ming-Kwong Yiu | 2017 | Asian Journal of Andrology2017，19，1： | 6 |
| 2 | Mathematical modeling for solving manufacturing run time problem with defective rate and random machine breakdown显示文摘 | PETER CHIU Y S LIN H D CHANG H H | 2011 | Computersand Industrial Engineering2011，60，4： | 1 |
| 3 | The behavioral and biochemical effects of BDNF containing polymers implanted in the hippocampus of rats 显示文摘 | Rachael W Sirianni Peter Olausson Amy S Chiu | 2010 | Brain Res2010，1321，： | 1 |
| 4 | Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms are not associated with premalignant gastric conditions: a combined haplotype analysis显示文摘 | Limas Kupcinskas Thomas Wex Juozas Kupcinskas Marcis Leja Audrius Ivanauskas Laimas Virgilijus Jonaitis Dainius Janciauskas Gediminas Kiudelis Konrads Funka Agnese Sudraba Han-Mo Chiu Jaw-Town Lin Peter Malfertheiner | 2010 | European Journal of Gastroenterology & Hepatology2010，，10： | 1 |
| 5 | Country and My People and Sydney Opera House:The missing link显示文摘It is known that Jφrn Utzon(1918-2008),the principal architect for the Sydney Opera House project(1957-66),had a lifetime obsession for Chinese art and architecture.However,previous studies did not explore the relationship between Utzon and his venerated Chinese writer Lin Yutang(1895-1976).How Utzon represented the ideas and ideals he received from Lin Yutang's conceptualization of Chinese art and architecture in My Country and My People(1935)has not been systematically documented.To this end,this article examines the role of Lin Yutang's work in Utzon's architectural career generally and the architect's Sydney Opera House design in particular.It argues that My Country and My People nurtured young Utzon's own architectural philosophy,as reflected in his early manifestoes and design projects.Eventually,Lin Yutang's Chinese aesthetics encapsulated in calligraphy,painting and architecture helped Utzon to initiate,articulate and further communicate the design principles of his Sydney Opera House,as well as several other important architectural works before and after.Although Utzon never fully realized his Opera House due to forced resignation in 1966,the inspiration from Lin Yutang vividly remains in Utzon's yet to be finished masterpiece. | Chen-Yu Chiu Philip Goad Peter Myers Nur Yildiz Ki lincer | 2019 | Frontiers of Architectural Research2019，8，2： | 1 |
| 6 | Experimental and Numerical Investigations: Alleviating Tensile Residual Stresses in Flash-butt Welds by Localized Rapid Post-weld Heat Treatment显示文摘 | David Tawfik Peter John Mutton Wing Kong Chiu | 2008 | Journal of Materials Processing Technology2008，196，13： | 1 |
| 7 | (August 2003) NFS over RDMA 显示文摘 | Callaghan Brent Lingutla - Raj Theresa Chiu Alex Staubach Peter Asad Omer Sun Microsystems | 2003 | Proceedings to the ACM SIGCOMM 2003 Workshops2003，3，2： | 1 |
| 8 | Does Erectile Dysfunction Contribute to Cardiovascular Disease Risk Prediction Beyond the Framingham Risk Score?显示文摘 | Andre B. Araujo Susan A. Hall Peter Ganz Gretchen R. Chiu Raymond C. Rosen Varant Kupelian Thomas G. Travison John B. McKinlay | 2010 | Journal of the American College of Cardiology2010，，4： | 1 |
| 9 | Chinese Colours and the Sydney Opera House (1956-1966): Jern Utzon' s Reinterpretation of Traditional Chinese Architecture 显示文摘 | Chiu Chen-Yu Peter Myers Philip Goad | 2013 | Journal of Design History2013，27，3： | 1 |
| 10 | Fuzzy gain scheduling for parallel parking a car-like robot 显示文摘 | Chiu Chian-song Lian Kuang-yow Liu Peter | 2005 | IEEE Transactions on Control Systems Technology2005，13，6： | 1 |
| 11 | Serum 25-hydroxyvitamin D concentration does not correlate with atopic dermatitis severity显示文摘 | Yvonne E. Chiu Peter L. Havens Dawn H. Siegel Omar Ali Tao Wang Kristen E. Holland Sheila S. Galbraith Valerie B. Lyon Beth A. Drolet | 2013 | Journal of the American Academy of Dermatology2013，，1： | 1 |
| 12 | LMI-based Fuzzy Chaotic Synchronization and Communication显示文摘 | Kuang-You Lian Chian-Song Chiu Tung-Sheng Chiang Peter Liu | 2001 | IEEE Transaction on Fuzzy Systems2001，9，4： | 1 |
| 13 | Transactive Energy and Flexibility Provision in Multi-microgrids Using Stackelberg Game显示文摘Aggregating demand side flexibility is essential to complementing the inflexible and variable renewable energy supply in achieving low carbon energy systems.Sources of demand side flexibility,e.g.,dispatchable generators,storage,and flexible loads,can be structured in a form of microgrids and collectively provided to utility grids through transactive energy in local energy markets.This paper proposes a framework of local energy markets to manage this transactive energy and facilitate the flexibility provision.The distribution system operator aims to achieve local energy balance by scheduling the operation of multi-microgrids and determining the imbalance prices.Multiple microgrid traders aim to maximize profits for their prosumers through dispatching flexibility sources and participating in localised energy trading.The decision making and interactions between a distribution system operator and multiple microgrid traders are formulated as the Stackelberg game-theoretic problem.Case studies using the IEEE 69-bus distribution system demonstrate the effectiveness of the developed model in terms of facilitating local energy balance and reducing dependency on the utility grids. | Weiqi Hua Hao Xiao Wei Pei Wei-Yu Chiu Jing Jiang Hongjian Sun Peter Matthews | 2023 | CSEE Journal of Power and Energy Systems2023，9，2： | 1 |
| 14 | Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron显示文摘SARS-CoV-2 variants with adaptive mutations have continued to emerge,causing fresh waves of infection even amongst vaccinated population.The development of broad-spectrum antivirals is thus urgently needed.We previously developed two hetero-bivalent nanobodies(Nbs),aRBD-2-5 and aRBD-2-7,with potent neutralization activity against the wild-type(WT)Wuhan isolated SARS-CoV-2,by fusing aRBD-2 with aRBD-5 and aRBD-7,respectively.Here,we resolved the crystal structures of these Nbs in complex with the receptor-binding domain(RBD)of the spike protein,and found that aRBD-2 contacts with highly conserved RBD residues and retains binding to the RBD of the Alpha,Beta,Gamma,Delta,Delta plus,Kappa,Lambda,Omicron BA.1,and BA.2 variants.In contrast,aRBD-5 and aRBD-7 bind to less conserved RBD epitopes non overlapping with the epitope of aRBD 2,and do not show apparent binding to the RBD of some variants.However,when fused with aRBD-2,they effectively enhance the overal binding affinity.Consistently,aRBD-2-5-Fc and aRBD-2-7 Fc potently neutralized all of the tested authentic or pseudotyped viruses,incuding WT,Alpha,Beta,Gamma,Delta,and Omicron BA.1,BA.1.1 and BA.2.Furthermore,aRBD-2-5-FC provided prophylactic protection against the WT and mouse-adapted SARS CoV-2 in mice,and conferred protection against the Omicron BA.1 variant in hamsters prophylatically and therapeutically,indicating that aRBD-2-5-Fc could potentially beneft the prevention and treatment of COVID-19 caused by the emerging variants of concern.Our strategy provides new solutions in the development of broad-spectrum therapeutic antibodies for COVID-19. | Huan Ma Xinghai Zhang Peiyi Zheng Peter H.Dube Weihong Zeng Shaohong Chen Qingyu Cheng Yunru Yang Yan Wu Junhui Zhou Xiaowen Hu Yan Xiang Huajun Zhang Sandra Chiu Tengchuan Jin | 2022 | Cell Research2022，32，9： | 1 |
| 15 | R&D intensity, firm performance and the identification of the threshold : fresh evidence from the panel threshold re- gression model显示文摘 | Ming - Liang Yell Hsiao - Ping Chu Peter Sher Yi - Chia Chiu | 2010 | Applied Economics2010，42，3： | 1 |
| 16 | Risk of cardiovascular thrombotic events after surgical castration versus gonadotropin-releasing hormone agonists in Chinese men with prostate cancer显示文摘我们与前列腺癌症在中国人在外科的阉割(SC ) 对释放 gonadotropin 荷尔蒙收缩筋(GnRHa ) 以后调查了心血管的 thrombotic 风险。从 2000 年与 SC 或 GnRHa 被对待到 2009 的所有中国前列腺癌症病人被考察并且比较。主要结果是在 SC 或 GnRHa 以后的心血管的 thrombotic 事件新发作的任何东西,它被定义为尖锐心肌的梗塞或 ischemic 击的任何事件。新发作的心血管的 thrombotic 事件的风险用 Kaplan-Meier 方法在 SC 组和 GnRHa 组之间被比较。穆尔蒂瓦里伊特·考克斯回归分析被执行为使因素惊讶的另外的潜力调整。684 个中国病人的一个总数在我们的学习被包括,包括在 SC 组的 387 个病人和在 GnRHa 组的 297 个病人。在 SC 组的吝啬的年龄(75.3 ±7.5 年) 比 GnRHa 组显著地高(71.8 ±8.3 年)(P <0.001 ) 。当时,有在 SC 组的新心血管的 thrombotic 事件的增加的风险与在 Kaplan-Meier 分析之上的 GnRHa 组相比(P = 0.014 ) 。在 multivariate 考克斯回归分析之上,变老(危险比率[HR ] 1.072, 95% 信心间隔[CI ] 1.04-1.11, P<0.001 ) , hyperlipidemia (HR 2.455, 95% CI 1.53-3.93, P<0.001 ) ,并且 SC (HR 1.648, 95% CI 1.05-2.59, P = 0.031 ) 是心血管的 thrombotic 事件的重要风险因素。在结论, SC 与心血管的 thrombotic 事件的增加的风险被联系什么时候与 GnRHa 相比。当决定雄激素剥夺治疗的方法时,这是一个重要方面考虑,特别在有 hyperlipidemia 的已知的历史的老人。 | Jeremy YC Teoh Samson YS Chan Peter KF Chiu Darren MC Poon Ho-Yuen Cheung Simon SM Hou Chi-Fai Ng | 2015 | Asian Journal of Andrology2015，17，3： | 0 |
| 17 | The challenges of developing an open source, standards-based technology stack to deliver the latest UK climate projections显示文摘To improve the understanding of local and regional effects of climate change,the UK government supported the development of new climate projections.The Met Office Hadley Centre produced a sophisticated set of probabilistic projections for future climate.This paper discusses the design and implementation of an interactive website to deliver those projections to a broad user community.The interface presents complex data sets,generates on-the-fly products and schedules jobs to an offline weather generator capable of outputting gigabytes of data in response to a single request.A robust and scalable physical architecture was delivered through significant use of open source technologies and open standards. | Ag Stephens Philip James David Alderson Stephen Pascoe Simon Abele Alan Iwi Peter Chiu | 2012 | International Journal of Digital Earth2012，5，1： | 0 |
| 18 | Transurethral resection of prostate for acute urinary retention is linked to shorter survival in younger men显示文摘It is largely unknown whether lower urinary tract symptoms(LUTS)or acute retention of urine(AROU)is linked to shorter life expectancy in men.We conducted a multicenter,retrospective database analysis of patients undergoing transurethral resection of prostate(TURP)to study their relationships.Multivariate Cox regression analysis and Kaplan-Meier analysis with stratification to age and indication of TURP were performed.We further performed an age-and sex-matched survival analysis with the general population using data from the Census and Statistics Department of the Hong Kong Special Administrative Region(Hong Kong,China).From January 2002 to December 2012,3496 patients undergoing TURP were included in our study,with 1764 patients in the LUTS group and 1732 patients in the AROU group.Old age,ischemic heart disease,cerebrovascular accident,and AROU were risk factors of mortality.Patients aged<70 years(adjusted hazard ratio[HR]:1.52,95%confidence interval[Cl]:1.11-2.09,P=0.010)and 70-80 years(adjusted HR:1.39,95%Cl:1.15-1.70,P-0.001)in the AROU group had worse survival than those in the LUTS group,but such difference was not demonstrated in patients aged>80 years.Compared to the general population,younger patients in the LUTS group appeared to have better survival(<70 years,P=0.091;70-80 years,P=0.011),but younger patients in the AROU group had worse survival(<70 years,P=0.021;70-80 years,P=0.003).For patients aged>80 years,survival was similar with the general population in both the LUTS and AROU groups.In conclusion,AROU at young age was associated with mortality,while early detection and management of LUTS may improve survival. | Jeremy Yuen-Chun Teoh Chi-Kwok Chan Maggie Haitian Wang Chi-Ho Leung Eddie Shu-Yin Chan Peter Ka-Fung Chiu Chi-Hang Yee Hon-Ming Wong Simon See-Ming Hou Chi-Fai Ng | 2019 | Asian Journal of Andrology2019，21，5： | 0 |
| 19 | Time trend and characteristics of prostate cancer diagnosed in Hong Kong(China)in the past two decades显示文摘Dear Editor, Prostate cancer is an important disease worldwide)In 2015 it was the third most common cancer diagnosed in male in Hong Kong (China) and the incidence of prostate cancer has been rising in the past 15 years. Meanwhile,with increasing public awareness,health education, presentation,and detection of prostate cancer maybe changed.Therefore, we would like to review how the epidemiology of prostate cancer in Hong Kong (China)had changed in the past two decades. | Ho-Fai Wong Chi-Hang Yee Jeremy YC Teoh Samson YS Chan Peter KF Chiu Ho-Yuen Cheung Simon SM Hou Chi Fai Ng | 2019 | Asian Journal of Andrology2019，21，1： | 0 |
| 20 | The combined role of MRI prostate and prostate health index in improving detection of significant prostate cancer in a screening population of Chinese men显示文摘Using prostate-specific antigen(PSA)for prostate cancer(PCa)screening led to overinvestigation and overdiagnosis of indolent PCa.We aimed to investigate the value of prostate health index(PHI)and magnetic resonance imaging(MRI)prostate in an Asian PCa screening program.Men aged 50–75 years were prospectively recruited from a community-based PSA screening program.Men with PSA 4.0–10.0 ng ml^(−1) had PHI result analyzed.MRI prostate was offered to men with PSA 4.0–50.0 ng ml−1.A systematic prostate biopsy was offered to men with PSA 4.0–9.9 ng ml^(−1) and PHI≥35,or PSA 10.0–50.0 ng ml^(−1).Additional targeted prostate biopsy was offered if they had PI-RADS score≥3.Clinically significant PCa(csPCa)was defined as the International Society of Urological Pathology(ISUP)grade group(GG)≥2 or ISUP GG 1 with involvement of≥30%of total systematic cores.In total,12.8%(196/1536)men had PSA≥4.0 ng ml^(−1).Among 194 men with PSA 4.0–50.0 ng ml^(−1),187(96.4%)received MRI prostate.Among them,28.3%(53/187)had PI-RADS≥3 lesions.Moreover,7.0%(107/1536)men were indicated for biopsy and 94.4%(101/107)men received biopsy.Among the men received biopsy,PCa,ISUP GG≥2 PCa,and csPCa was diagnosed in 42(41.6%),24(23.8%),and 34(33.7%)men,respectively.Compared with PSA/PHI pathway in men with PSA 4.0–50.0 ng ml^(−1),additional MRI increased diagnoses of PCa,ISUP GG≥2 PCa,and csPCa by 21.2%(from 33 to 40),22.2%(from 18 to 22),and 18.5%(from 27 to 32),respectively.The benefit of additional MRI was only observed in PSA 4.0–10.0 ng ml^(−1),and the number of MRI needed to diagnose one additional ISUP GG≥2 PCa was 20 in PHI≥35 and 94 in PHI<35.Among them,45.4%(89/196)men with PSA≥4.0 ng ml^(−1) avoided unnecessary biopsy with the use of PHI and MRI.A screening algorithm with PSA,PHI,and MRI could effectively diagnose csPCa while reducing unnecessary biopsies.The benefit of MRI prostate was mainly observed in PSA 4.0–9.9 ng ml^(−1) and PHI≥35 group.PHI was an important risk stratification step for PCa screening. | Peter KF Chiu Thomas YT Lam Chi-Fai Ng Jeremy YC Teoh Carmen CM Cho Hiu-Yee Hung Cindy Hong Monique J Roobol Winnie CW Chu Samuel YS Wong Joseph JY Sung | 2023 | Asian Journal of Andrology2023，25，6： | 0 |
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