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您的检索式：作者名="Peter E Butler"
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| 1 | Current progress in use of adipose derived stem cells in peripheral nerve regeneration显示文摘Unlike central nervous system neurons; those in the peripheral nervous system have the potential for full regeneration after injury. Following injury, recovery is controlled by schwann cells which replicate and modulate the subsequent immune response. The level of nerve recovery is strongly linked to the severity of the initial injury despite the significant advancements in imaging and surgical techniques. Multiple experimental model shave been used with varying successes to augment the natural regenerative processes which occur following nerve injury. Stem cell therapy in peripheral nerve injury may be an important future intervention to improve the best attainable clinical results. In particular adipose derived stem cells(ADSCs) are multipotent mesenchymal stem cells similar to bone marrow derived stem cells, which are thought to have neurotrophic properties and the ability to differentiate into multiple lineages. They are ubiquitous within adipose tissue; they can form many structures resembling the mature adult peripheral nervous system. Following early in vitro work; multiple small and large animal in vivo models have been used in conjunction with conduits, autografts and allografts to successfully bridge the peripheral nerve gap. Some of the ADSC related neuroprotective and regenerative properties have been elucidated however much work remains before a model can be used successfully in human peripheral nerve injury(PNI). This review aims to provide a detailed overview of progress made in the use of ADSC in PNI, with discussion on the role of a tissue engineered approach for PNI repair. | Shomari DL Zack-Williams Peter E Butler Deepak M Kalaskar | 2015 | World Journal of Stem Cells2015，7，1： | 8 |
| 2 | Control of stem cell fate by engineering their micro and nanoenvironment显示文摘Stem cells are capable of long-term self-renewal and differentiation into specialised cell types, making them an ideal candidate for a cell source for regenerative medicine. The control of stem cell fate has become a major area of interest in the field of regenerative medicine and therapeutic intervention. Conventional methods of chemically inducing stem cells into specific lineages is being challenged by the advances in biomaterial technology, with evidence highlighting that material properties are capable of driving stem cell fate. Materials are being designed to mimic the clues stem cells receive in their in vivo stem cell niche including topographical and chemical instructions. Nanotopographical clues that mimic the extracellular matrix(ECM) in vivo have shown to regulate stem cell differentiation. The delivery of ECM components on biomaterials in the form of short peptides sequences has also proved successful in directing stem cell lineage. Growth factors responsible for controlling stem cell fate in vivo have also been delivered via biomaterials to provide clues to determine stem cell differentiation. An alternative approach to guide stem cells fate is to provide genetic clues including delivering DNA plasmids and small interfering RNAs via scaffolds. This review, aims to provide an overview of the topographical, chemical and molecular clues that biomaterials can provide to guide stem cell fate. The promising features and challenges of such approaches will be highlighted, to provide directions for future advancements in this exciting area of stem cell translation for regenerative medicine. | Michelle F Griffin Peter E Butler Alexander M Seifalian Deepak M Kalaskar | 2015 | World Journal of Stem Cells2015，7，1： | 3 |
| 3 | Advancing cartilage tissue engineering: the application of stem cell technology显示文摘 | Joanne Raghunath Henryk J Salacinski Kevin M Sales Peter E Butler Alexander M Seifalian | 2005 | Current Opinion in Biotechnology2005，，5： | 1 |
| 4 | ^sup 11^C-Dihydrotetrabenazine PET of the Pancreas in Subjects with Long-Standing Type 1 Diabetes and in Healthy Controls显示文摘 | Goland Robin Freeby Matthew Parsey Ramin Saisho Yoshifumi Kumar Dileep Simpson Norman Hirsch Joy Prince Martin Maffei Antonella Mann J John Butler Peter C Van Heertum Ronald Leibel Rudolph L Ichise Masanori Harris Paul E | 2009 | The Journal of Nuclear Medicine2009，，3： | 1 |
| 5 | 面部移植 一种修复重度面部损伤的新方法显示文摘世界上第一例面部移植手术已经由法国报道了,但是判断它是否是整形再造外科一个新领域开始的标志,还要根据其临床结果而定。长期以来,面部移植手术一直被认为是技术上的挑战,但它在临床上是可行的。。对面部重度畸形的患者来说,这项手术的优点是对其功能、美容和心理均有所改善,而缺点是要求长期应用免疫抑制剂,所以争论的关键在于该手术是否利大于弊。 | Peter E M Butler Alex Clarke Shehan Hettiaratchy 晏晓青 | 2006 | 英国医学杂志中文版2006，9，2： | 0 |
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