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| 1 | Coronary artery disease in congenital single coronary artery in adults:A Dutch case series显示文摘AIM:To assess the current diagnostic and therapeutic management and the clinical implications of congenital single coronary artery(SCA) in adults.METHODS:We identified 15 patients with a SCA detected from four Dutch angiography centers in the period between 2010 and 2013.Symptomatic patients who underwent routine diagnostic coronary angiography(CAG) for suspected coronary artery disease and who incidentally were found to have isolated SCA were analyzed.RESULTS:Fifteen(7 females) with a mean age of 58.5 ± 13.78 years(range 43-86) had a SCA.ConventionalCAG demonstrated congenital isolated SCA originating as a single ostium from the right sinus of Valsalva in 6 patients and originating from the left in 9 patients.Minimal to moderate coronary atherosclerotic changes were found in 4,and severe stenotic lesions in another 4 patients.Seven patients were free of coronary atherosclerosis.Runs of non-sustained ventricular tachycardia were documented in 2 patients,one of whom demonstrated transmural ischemic changes on presentation.Myocardial perfusion scintigraphic evidence of transmural myocardial ischemia was found in 1 patient due to kinking and squeezing of the SCA with an interarterial course between the aorta and pulmonary artery.Multi-slice computed tomography(MSCT) was helpful to delineate the course of the anomalous artery relative to the aorta and pulmonary artery.Percutaneous coronary intervention was successfully performed in 3 patients.Eight patients were managed medically.Arterial bypass graft was performed in 4 patients with the squeezed SCA.CONCLUSION:SCA may be associated with transient transmural myocardial ischemia and aborted sudden death in the absence of coronary atherosclerosis.The availability and sophistication of MSCT facilitates the delineation of the course of a SCA.We present a Dutch case series and review of the literature. | Salah AM Said Willem G de Voogt Suat Bulut Jacques Han Peter Polak Rogier LG Nijhuis Jeroen W op den Akker Andries Slootweg | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 2 | New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study显示文摘 | Leena I Kauppila Joseph F Polak L.Adrienne Cupples Marian T Hannan Douglas P Kiel Peter W.F Wilson | 1997 | Atherosclerosis1997，，2： | 1 |
| 3 | International Liquidity and the Role of the SDR in the International Monetary System显示文摘 | Peter Barton Clark and Jacques Jacobus Polak | 2004 | IMF Staff Papers2004，51，1： | 1 |
| 4 | A novel ALS SOD1 C6S mutation with implications for aggregation related toxicity and genetic counseling显示文摘 | Terrell Brotherton Meraida Polak Crystal Kelly Anna Birve Peter Andersen Stefan L. Marklund Jonathan D. Glass | 2011 | Amyotrophic Lateral Sclerosis2011，，3： | 1 |
| 5 | Abdominal Aortic Calcific Deposits Are an Important Predictor of Vascular Morbidity and Mortality显示文摘 | Peter W.F. Wilson Leena I. Kauppila Christopher J. O’Donnell Douglas P. Kiel Marian Hannan Joseph M. Polak L. Adrienne Cupples | 2001 | Circulation: Journal of the American Heart Association2001，，11： | 1 |
| 6 | 颈动脉内膜中层厚度测量未改善高血压患者心血管风险预测显示文摘颈动脉内膜中层厚度(carotid intima-media thickness,CIMT)是心血管风险的标志。目前仍不清楚颈总动脉CIMT测量能否改善高血压患者10年内首发心肌梗死或脑卒中的风险预测。研究人员获取正在进行的大规模荟萃分析:USE-IMT研究中的高血压参与者(收缩压≥140和舒张压≥90 mm Hg,1mm Hg=0.133kPa)数据进行分析。 | Bots ML Groenewegen KA erson TJ Britton AR Dekker JM Engstrm G Evans GW de Graaf J Grobbee DE Hedblad B Hofman A Holewijn S Ikeda A Kavousi M Kitagawa K Kitamura A Ikram MA Lonn EM Lorenz MW Mathiesen EB Nijpels G Okazaki S O'Leary DH Polak JF Price JF Robertson C Rembold CM Rosvall M Rundek T Salonen JT Sitzer M Stehouwer CD Franco OH Peters SA den Ruijter HM 赵狄 | 2014 | 中华高血压杂志2014，22，6： | 0 |
| 7 | Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults:Big Data from Seven Randomized Controlled Trials Worldwide显示文摘Objective.The strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TCF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized controlled trials(RCTs).Methods.From October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 RCTs.These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults.Gene treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all studies.Results.In the joint analysis,a total of 7 eligible RCTs were included(n=4,114).Importantly,we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting glucose.Compared with the control group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,p<0:05;z=2:20,p=0:028)per one copy of the TCF7L2 T risk allele.Furthermore,regardless of genetic risk,diet/lifestyle interventions were associated with lower waist circumference.However,there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk allele.Conclusions.Our findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults. | Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros Liana C.Del Gobbo Jordi Salas-Salvadó Miguel A.Martínez-González Jan Polak Markku Laakso Arne Astrup Dominique Langin Jorg Hager Gabby Hul Torben Hansen Oluf Pedersen Jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat Cofán Sujatha Rajaram Jaakko Tuomilehto Jaana Lindström Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen Christopher D.Gardner Joan Sabaté Dolores Corella J.Alfredo Martinez Lu Qi | 2021 | Health Data Science2021，，1： | 0 |
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