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| 1 | Gene expression profile of esophageal cancer in North East India by cDNA microarray analysis显示文摘AIM: To identify alterations in genes and molecular functional pathways in esophageal cancer in a high incidence region of India where there is a widespread use of tobacco and betel quid with fermented areca nuts. METHODS: Total RNA was isolated from tumor and matched normal tissue of 16 patients with esophageal squamous cell carcinoma. Pooled tumor tissue RNA was labeled with Cy3-dUTP and pooled normal tissue RNA was labeled with Cy5-dUTP by direct labeling method. The labeled probes were hybridized with human 10K cDNA chip and expression profiles were analyzed by Genespring GX V 7.3 (Silicon Genetics). RESULTS: Nine hundred twenty three genes were differentially expressed. Of these, 611 genes were upregulated and 312 genes were downregulated. Using stringent criteria (P ≤ 0.05 and ≥ 1.5 fold change), 127 differentially expressed genes (87 upregulated and 40 downregulated) were identified in tumor tissue. On the basis of Gene Ontology, four different molecular functional pathways (MAPK pathway, G-protein coupled receptor family, ion transport activity, and serine or threonine kinase activity) were most significantly upregulated and six different molecular functional pathways (structural constituent of ribosome, endopeptidase inhibitor activity, structural constituent of cytoskeleton, antioxidant activity, acyl group transferase activity, eukaryotic translation elongation factor activity) were most significantly downregulated. CONCLUSION: Several genes that showed alterations in our study have also been reported from a high incidence area of esophageal cancer in China. This indicates that molecular profiles of esophageal cancer in these two different geographic locations are highly consistent. | Indranil Chattopadhyay Sujala Kapur Joydeep Purkayastha Rupkumar Phukan Amal Kataki Jagadish Mahanta Sunita Saxena | 2007 | World Journal of Gastroenterology2007，13，9： | 3 |
| 2 | Dietary habits and stomach cancer in Mizoram, India显示文摘 | Rup Kumar Phukan Konwar Narain Eric Zomawia Nakul Chandra Hazarika Jagadish Mahanta | 2006 | Journal of Gastroenterology2006，，5： | 2 |
| 3 | A Position Synchronization Controller for Co-ordinated Links(COOL)Dual Robot Arm Based on Integral Sliding Mode:Design and Experimental Validation显示文摘In this study,a simple position synchronization control algorithm based on an integral sliding mode is developed for dualarm robotic manipulator systems.A first-order sliding surface is designed using cross-coupling error in order to ensure position synchronization of dual-arm manipulators.The design objective of the proposed controller is to ensure stability as well as to synchronize the movement of both arms while maintaining the trajectory as desired.The integral sliding mode eliminates the reaching phase and guarantees robustness throughout the whole operating period.Additionally,a low pass filter is used to smoothen the discontinuous element and minimize unwanted chattering.Lyapunov stability theory is utilized to prove the asymptotic stability of the controlled system.Simulation studies are performed to validate the proposed controller′s effectiveness.Also,to investigate the possibility of realizing the proposed dynamic control method in practical applications,experiments are conducted on a 14DoF coordinated links(COOL)dual-arm robotic manipulator system.Experimental evidence indicates adequate efficiency in trajectory tracking and guarantees robustness in the presence of parametric uncertainty and external disturbance. | Sumi Phukan Chitralekha Mahanta | 2021 | International Journal of Automation and computing2021，18，1： | 2 |
| 4 | TGFBR1 6A enhances themigration and invasion of MCF-7 breast cancer cells through RhoAactivation显示文摘 | Rosman DS Phukan S Huang CC | 2008 | Cancer Res2008，68，5： | 1 |
| 5 | TGFBR1 6A enhances the migration and invasion of MCF-7 breast cancer cells through RhoA activation 显示文摘 | Rosman DS Phukan S Huang CC | 2008 | Cancer Res2008，68，5： | 1 |
| 6 | Flexible Routes to the 5-hydroxy acid of the Cryptophycins显示文摘 | Phukan P Sasmal S Maier M E | 2003 | Eur J Org Chem2003，9，： | 1 |
| 7 | A typological study of words in Kokborok language of Tripura显示文摘 | Basumatary Phukan C | 2015 | International Journal of Humanities and Social Science Invention2015，，4： | 1 |
| 8 | Differential regulation of early growth response gene-1 expression by insulin and glucose in vascular endothelial celss显示文摘 | Hasan RN Phukan S Harada S | 2003 | Arterioscler Throumb Vast: Biol2003，23，6： | 1 |
| 9 | Iodine as an extremely powerful catalyst for the acetylation of alcohols under solvent-free conditions显示文摘 | Phukan P | 2004 | Tetrahedron Letters2004，45，： | 1 |
| 10 | Tobacco use and stomach cancer in Mizoram, India 显示文摘 | Phukan RK Zomawia E Narain K | 2005 | Cancer Epidemiol Biomarkers Prey2005，14，8： | 1 |
| 11 | Role of dietary habits in the development of esophageal cancer in Assam, the north-eastern region of India 显示文摘 | Chetia CK Ali MS Mahanta J | 2001 | Nutr Cancer2001，39，2： | 1 |
| 12 | CuI as reusable catalyst for the Biginelli reaction显示文摘 | Kalita H R Phukan P | 2007 | Catalysis Communications2007，8，2： | 1 |
| 13 | GSK3beta: role in therapeutic landscape and development of modulators 显示文摘 | Phukan S Babu V S Kannoji A | 2010 | Br J Pharmacol2010，160，1： | 1 |
| 14 | Cognitive impairment in amyotrophie lateral sclerosis显示文摘 | Phukan J Pender NP Hardiman O | 2007 | Lancet Neural2007，6，11： | 1 |
| 15 | Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis 显示文摘 | Phukan J | 2010 | Drugs2010，13，7： | 1 |
| 16 | Genetic polymorphism of glutathione S-transferases M1 and T1,tobacco habits and risk of stomach cancer in Mizoram,India显示文摘 | Malakar M Devi KR Phukan RK | 2012 | Asian Pac J Cancer Prev2012，13，9： | 1 |
| 17 | Executivedysfunction is a negative prognostic indicator in patients withALS without dementia 显示文摘 | ELAMIN M PHUKAN J BEDE P | 2011 | Neurology2011，76，14： | 1 |
| 18 | Operative compared with nonoperative treatment of a thoracolumbar burst fracture without neuro- logical deficit:a prospective randomized study with follow-up at sixteen to twenty-two years 显示文摘 | Wood KB Buttermann GR Phukan R | 2015 | J Bone Joint Surg Am2015，97，1： | 1 |
| 19 | Reaction of certain cucumber cuhivars to root-knot nematode, Meloidogyne incognita 显示文摘 | Bharali A Phukan P N | 1996 | Journal of the Agricultural Science Society of North East India1996，9，： | 1 |
| 20 | A cholera epidemic in a rural area of northeast India显示文摘 | Phukan A C Borah P K Biswas D | 2004 | Transactions of the Royal Society of Tropical Medicine and Hygiene2004，，9： | 1 |
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